Obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats

Abstract

Obesity and hyperlipidemia modulate the host response to challenges in the periodontium, increasing the expression of periodontal breakdown.

Is there a relationship between hyperlipidemia and periodontitis?

“…63 It is widely known that lifestyle adjustments such as increased level of physical activity, decreased level of alcohol consumption, acceptable dietary habit and stress administration are significant issues not only in the prevention of hyperlipidemia but also in the treatment of CVD. 64,65 Although BMI result of our study which represents an objective parameter compare to the diet is in line with the literature, 31,37,62,66 dietary habits of patients were similar. The physical activity and alcohol consumption results of the present study are in conformity with the studies suggesting a possible interaction between hyperlipidemia and periodontal disease.…”

“…31,59 It has been suggested that dietary lipids and endotoxins can stimulate PMNL which play a major role in the pathogenesis of periodontitis. 31,60,61 Recently published studies also concluded that obesity and hyperlipidemia can alter the host response leading to increase periodontal breakdown 62 and a cholesterol-enriched diet could lead to alveolar bone loss together with increasing periodontal inflammation and serum pro-oxidants levels. 63 It is widely known that lifestyle adjustments such as increased level of physical activity, decreased level of alcohol consumption, acceptable dietary habit and stress administration are significant issues not only in the prevention of hyperlipidemia but also in the treatment of CVD.…”

“…48,49,65,67 A probable association between hyperlipidemia and periodontitis were investigated by assessing the biochemical parameters together with periodontal parameters in a number of studies. 22,31,36,37,47,62,[67][68][69] Sangwan et al 37 reported significant positive associations between PD and TC, CAL and LDL-C as well as between GI and TG. Similarly, our findings suggest a positive correlation between PD and TC, CAL and LDL-C parameters, however, no significant correlation was present between GI and TG levels.…”

“…This difference can be explained with discrepancies in the disease profile and severity of the participants included to the studies. On the other hand, Cavagni et al 62 evaluated the role of obesity/hyperlipidemia on alveolar bone loss in rats and reported that the animals with obesity/hyperlipidemia together with alveolar bone loss showed statistically significantly higher TG and TC levels than those without periodontal breakdown. Interestingly our BMI results strongly support these evidences with detected positive correlations with TG, TC, LDL-C and CAL parameters.…”

Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis

“…Hyperlipidaemia is a proinflammatory state in which increased oxidative stress and endothelial dysfunction is seen . Some studies have reported that hyperlipidaemia in rats results in alveolar bone loss (ABL) without periodontitis …”