Effect of immobilization with chondroitin‐6‐sulfate and grafting with chitosan on fibroblast and antibacterial activity of polyester fibers

Abstract

Poly(ethylene terephthalate) (PET) fibers were treated with 60Co‐γ‐ray and grafted with acrylic acid (AA), and further grafted with chitosan (CS) via esterification. Afterwards these CS‐grafted fibers were then immobilized with chondroitin‐6‐sulfate (ChS). The blood compatibility of PET was reduced by grafting with CS, while improved by immobilizing with ChS. The antibacterial activity of CS against Staphylococcus aureus, and Pseudomonas aeruginosa was retained after ChS‐immobilization. After immobilizing ChS, the L929 fibroblasts cell proliferation was higher than CS‐grafting PET fibers. The results indicate that by grafting with CS and immobilizing with ChS, PET fibers can not only exhibit antibacterial activity, but also improve the cell proliferation for fibroblast activity. Copyright © 2005 John Wiley & Sons, Ltd.

Surface Characterization and Antimicrobial Activity of Chitosan-Deposited DBD Plasma-Modified Woven PET Surface

“…Up to now, there have been some studies reporting the chitosan deposition on PET surface by using many techniques, i.e. oxygen glow plasma treatment followed by acrylic acid graft polymerization and chitosan deposition [15], radio frequency plasma treatment followed by UV-induced acrylamide graft polymerization and chitosan deposition with the aid of glutaradehyde crosslinking agent [16], 60 Co-c-ray treatment followed by acrylic acid graft polymerization and chitosan deposition [17], alkali hydrolysis treatment followed by chitosan deposition [18,19], aminolysis pretreatment followed by acid hydrolysis treatment and layer-by-layer assembly of polyelectrolyte and chitosan [20], ozone treatment followed by chitosan deposition [21], and electrospinning of a mixture of PET and chitosan dissolved in solvents [22,23]. However, to our knowledge, the research on chitosan deposition on the woven PET surface simply modified by the DBD plasma for improving antimicrobial property has not yet been extensively examined.…”

Preparation of animal polysaccharides nanofibers by electrospinning and their potential biomedical applications

“…Other animal polysaccharides, for example, ChS, could be used in the electrospinning process, with or without polymer additives . A novel nanofibrous collagen‐ChS scaffold was constructed by electrospinning collagen blended with ChS in a mixed solvent of TFE and water.…”

“…Chondroitin‐6‐sulfate (Ch6S), an anionic polysaccharide, consists of repeating disaccharide unit of acetylgalactosamine 6‐sulfate and D‐glucuronic acid. ChS grafting polyester fibers are found to show antibacterial activity against pathogenic bacteria and reduce the growth of fibroblasts . The nanofibrous collagen/Ch6S composite scaffold was prepared by electrospinning technology.…”

Synthesis of potato starch sulfate and optimization of the reaction conditions

“…Nowadays, polysaccharides and polysaccharide sulfates have attracted chemical and biological researchers' attention because of their wide various biological activities, such as high anti-virus activity, anti-HIV activity and anti-hemoglutination properties [1][2][3][4][5][6]. The further research shows that these biological activities are closely related to the sulfate ester groups which connect to the anhydroglucose units (AGU) in polysaccharides [7,8].…”