Effect of IGF-Rich Colostrum on Bowel Adaptation in Neonatal Piglets With Short Bowel Syndrome

Abstract

Colostrum supplement rich in IGF-1 has no benefits over protein-enriched feed with respect to growth and bowel adaptation in neonatal piglets with short bowel syndrome.

Models of Short Bowel Syndrome in Pigs: A Technical Review

“…The majority of studies used domestic pigs or piglets [5,13,16,17,18,19] mainly of female gender [10,13,16,18,20,21,22,23,24,25,26,27,28,29]. Regarding the exact breed, mostly landrace [10,21,22,30,31] or landrace × large white [5,13,16,20,24,26,32,33,34] animals were used.…”

“…Regarding the exact breed, mostly landrace [10,21,22,30,31] or landrace × large white [5,13,16,20,24,26,32,33,34] animals were used. SBS models were seldom described in other types of pig [7,23].…”

“…Seventy-three percent of the authors performed a resection of 75% [10,13,16,18,21,22,24,26,27,28,32,33,34] or 80% of the small bowel [5,29,30,35,37], and in 8 and 19% of the articles, 90% [19,23] and 95-100% [7,25,30,31,36] of the small bowel was resected, respectively. The bowel was resected in two main areas: most of the authors described a mid-intestinal resection in which the remaining small bowel consists of equal parts of the jejunum and ileum [5,10,18,21,22,27,28,29,30,31,34,35]; other authors used a 75% resection model in which the jejunum was resected 0.5 [24,26,32] to 1 m [20,33] distal of the ligament of Treitz proximally and the ileum up to 2.5 m proximal to the ileocecal valve distally [13,16,20,24,26,32,33]. No author described a resection of the ileocecal valve.…”

“…No author described a resection of the ileocecal valve. In those publications that described the surgical technique in detail, only end-to-end anastomoses were reported [5,21,22,24,26,29,32,34,35,37]; the anastomoses were mainly performed in a single-layer technique [5,10,19,25,26,27,28,32] with interrupted sutures [21,22,24,26,27,28,32,34,35,37]. Running sutures were rarely observed [10,18,25].…”

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

“…26 The protein content is very high (B11% v/v), and the whey proteins include a-lactalbumin, b-lactoglobulin, serum albumin, immunoglobulins, lactoferrin and peptide hormones such as growth hormone 27 and insulin-like growth factors, 28 epidermal growth factor, 29 betacellulin, 27 transforming growth factor b 30 and platelet-derived growth factor. 26 In cell-lines, animal models 31,32 and human studies, 33 such growth factors have shown potential for proliferation and differentiation of both immature and mature cells in the gastrointestinal tract.…”