Models of Short Bowel Syndrome in Pigs: A Technical Review

Weih, Sandra; Nickkholgh, Arash; Keßler, M.; Frongia, Giovanni; Hafezi, Mohammadreza; Golriz, Mohammad; Fard, Navide Heis-Vahidi; Holland‐Cunz, Stefan; Mehrabi, Arianeb

doi:10.1159/000354806

Cited by 17 publications

(9 citation statements)

References 87 publications

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“…A technical review of 27 articles reporting porcine SBS models demonstrated great heterogeneity in age, weight, and sex of pigs, as well as percent and location of SBR performed. Experimental numbers were low, and mortality ranged from 6 to 18% where reported (52). One report of 75% SBR in 7-day-old piglets reported 8% mortality rate at 28 days; however, the animals were fed a standard amount of calories per body weight daily and were supplemented with electrolytes, additional costly and workintensive interventions (15).…”

Section: Discussionmentioning

confidence: 99%

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

Schall

Holoyda

Grant

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 99%

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

Schall

Holoyda

Grant

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…The immunosuppressive drug tacrolimus has direct vasodilative effects on the porcine SMA, which might also be adressed in further studies is the extrapolation of our findings from a porcine model to the clinical situation. Important species‐related pathophysiological distinctions are possible; however, pigs are morphologically and physiologically similar to humans and represent a well‐characterized large animal model for surgical research on intestinal failure and SBTX . Nevertheless, clinical studies are necessary.…”

Section: Discussionmentioning

confidence: 99%

The optimal intestinal segment length for experimental size‐mismatched intestinal transplantation: Defining the maximum length with the lowest blood flow needs in a porcine model

Frongia

Majlesara

Saffari

et al. 2018

Pediatric Transplantation

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Transplanted Intestinal Segments (IS) must match the perfusion capacities of the recipient. This can be challenging during a size-mismatched SBTX. In this study, we defined the maximum IS length with lowest blood flow needs in a porcine model by evaluating the physiological perfusion rates of different IS lengths. Blood flow in the SMA, aorta segment four, and general circulatory parameters were monitored before and after sequential intestinal resection. IS lengths of 30 cm, 60 cm, 120 cm, and 300 cm (n = 8 each) were compared. The IS blood flow requirements increased with IS length (30 cm: 19.5 ± 3.4 mL/min; 60 cm: 16.9 ± 6.7 mL/min; 120 cm: 34.9 ± 8.5 mL/min; 300 cm: 62.9 ± 11.6 mL/min). Absolute IS blood flow (P = .004), percentage IS blood flow uptake from the SMA (P = .001), and percentage IS blood flow uptake from the aorta (P = .005) increased significantly between 60 cm and 120 cm. We concluded that 60 cm was the maximum IS length before blood flow demands significantly increased in a porcine model.

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“…The development of these latter models is especially relevant, as they represent the types of SBS seen most in human neonates, with resection of the ileum and/or creation of an end‐jejunostomy, and offer the greatest translational benefit. Interestingly, a recent technical review of piglet models of SBS noted a limitation that current piglet models of SBS were inconsistent, and there was a lack of a standardized model 72 . We believe that differences in neonatal piglet models of SBS relate to the fact that SBS is a heterogeneous disease.…”

Section: Emerging Piglet Models Of Neonatal Sbsmentioning

confidence: 99%

Emerging Piglet Models of Neonatal Short Bowel Syndrome

Lim

Turner

Wales

2014

J Parenter Enteral Nutr

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Short bowel syndrome (SBS) is a growing problem in the human neonatal population. In infants, SBS is the leading cause of intestinal failure, the state of being unable to absorb sufficient nutrients for growth and development. Neonates with SBS are dependent on long-term parenteral nutrition therapy, but many succumb to the complications of sepsis and liver disease. Research in neonatal SBS is challenged by the ethical limits of studying sick human neonates and the heterogeneous nature of the disease process. Outcomes in SBS vary depending on residual intestinal anatomy, intestinal length, patient age, and exposure to nutrition therapies. The neonatal piglet serves as an appropriate translational model of the human neonate because of similarities in gastrointestinal ontogeny, physiological maturity, and adaptive processes. Re-creating the disease process in a piglet model presents a unique opportunity for researchers to discover novel insights and therapies in SBS. Emerging piglet models of neonatal SBS now represent the entire spectrum of disease seen in human infants. This review aims to contextualize these emerging piglet models within the context of SBS as a heterogeneous disease. We first explore the factors that account for SBS heterogeneity and then explore the suitability of the neonatal piglet as an appropriate translational animal model. We then examine differences between the emerging piglet models of neonatal SBS and how these differences affect their translational potential to human neonates with SBS.

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Models of Short Bowel Syndrome in Pigs: A Technical Review

Cited by 17 publications

References 87 publications

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration

The optimal intestinal segment length for experimental size‐mismatched intestinal transplantation: Defining the maximum length with the lowest blood flow needs in a porcine model

Emerging Piglet Models of Neonatal Short Bowel Syndrome

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