Effect of ibuprofen entrapment procedure on physicochemical and controlled drug release performances of chitosan/xanthan gum polyelectrolyte complexes

Ćirić, Ana; Medarević, Djordje; Čalija, Bojan; Dobričić, Vladimir; Rmandić, Milena; Barudžija, Tanja; Malenović, Anđelija; Djekić, Ljiljana

doi:10.1016/j.ijbiomac.2020.11.201

Cited by 25 publications

(35 citation statements)

References 55 publications

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“…Also, xanthan gum can provide time-independent drug release kinetics (13). PECs of chitosan and xanthan gum are usually prepared by combining the aqueous dispersions of polymers (10,14,15). The formation of PECs is a consequence of mixing the aqueous solutions of polycation and polyanion and the establishment of electrostatic/ionic interaction between them.…”

Section: Introductionmentioning

confidence: 99%

“…All methods mentioned above can be used for the entrapment of small molecules, while macromolecules can be incorporated either by premixing with the like-charged polyelectrolyte before the complexation or via adsorption on the surface of the already formed PEC (17). The obtained PEC dispersions can be subjected to various drying methods such as spray-drying (18), freeze-drying (lyophilization) (19), or can be oven-dried (20), and dried under ambient conditions (15). Different drying methods can produce PECs of different morphology, physicochemical and biopharmaceutical properties (21).…”

Section: Introductionmentioning

confidence: 99%

“…The shape of particles can be easily defined by calculating their elongation ratio (ER) (length-to-width ratio). Some studies define particles with ER=1 as perfectly spherical, with 1<ER<1.15 as spherical, and with ER>1.15 as non-spherical (15,(25)(26)(27)(28). Various drying parameters, such as dispersion flow rate and inlet temperature, can be adjusted to obtain a product within defined characteristics and appropriate stability (29).…”

Section: Introductionmentioning

confidence: 99%

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Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as carriers for oral delivery of ibuprofen

Ćirić¹,

Milinković-Budinčić²,

Medarević³

et al. 2022

Arhiv za farmaciju

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Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation of solid oral dosage forms requires the drying of PECs, which may affect their physicochemical and biopharmaceutical properties. The aim of this study was to investigate the effect of spraydrying on the properties of ibuprofen-loaded chitosan/xanthan gum PECs and to assess the drug release kinetics from such PECs filled into hard capsules in comparison with corresponding PECs which are dried under ambient conditions. The yield, ibuprofen content, entrapment efficiency, and residual moisture content of spray-dried PECs were lower than those of ambient-dried PECs. Better flowability of spray-dried PECs was attributed to the almost spherical particle shape, shown by scanning electron microscopy. DSC and PXRD analysis confirmed the amorphization of ibuprofen during spray-drying. All the investigated PECs, obtained by drying under ambient conditions as well as by spray-drying, had high rehydration capacity both in 0.1 M hydrochloric acid (pH 1.2) and phosphate buffer pH 7.4. In vitro ibuprofen release from dried PECs was controlled during 12 h with the release of approximately 30% of entrapped ibuprofen. Spray-dried PECs provided better control of ibuprofen diffusion from the carrier compared to the ambientdried ones.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as carriers for oral delivery of ibuprofen

Ćirić¹,

Milinković-Budinčić²,

Medarević³

et al. 2022

Arhiv za farmaciju

Self Cite

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show abstract

“…It is well known that ibuprofen is an effective non-steroidal anti-inflammatory drug used for the management of pain, symptoms of rheumatoid arthritis, and fever. However, its low solubility, short biological half-life, and rapid clearance after oral administration limited the wide application and lead to wasted dosing and potentially serious side effects ( Wang et al, 2020a ; Uchiyama et al, 2021 ; Ćirić et al, 2021 ). Traditional drug delivery systems cannot satisfy the long-term and continuous release of ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

“…Polymer aerogels are also the promising material in the design of transdermal delivery systems for ibuprofen ( Wang et al, 2020b ; Ramöller et al, 2020 ; Jaber et al, 2021 ), and they can achieve a suitable combination of polymer–drug compatibility, skin permeation, and in vitro release kinetics and swelling ratio. However, it is the major challenge to develop the ibuprofen formulations for controlling the release of drugs in transdermal delivery systems and achieving drug prolonged administration ( Wang et al, 2020b ; Ćirić et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen

Wang

Xie

2021

Front. Chem.

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Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer–drug aerogels have attracted huge interest in optimizing the drug delivery efficiency and improving the physicochemical characteristics and therapeutic quality. Here, chitosan–ibuprofen aerogels with excellent swelling, high biocompatibility, and better drug delivery efficiency were synthesized by a simple method. Our study found that the chitosan–ibuprofen aerogels exhibited remarkably improved thermal stability, excellent swelling ratio, and high drug loading. As a consequence of these favorable properties, the chitosan–ibuprofen aerogels exhibited improved drug delivery efficiency and achieved drug prolonged administration. Our study highlights the great potential of polymer–drug aerogels in improving the drug delivery efficiency of transdermal drug delivery systems.

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Quantum Chemistry and Pharmacy: Diagnostic Check of the Thermochemistry of Ibuprofen

Emel'yanenko,

Zherikova,

Verevkin

2024

ChemPhysChem

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The thermodynamic data on ibuprofen available in the literature shows that the disarray of experimental results is unacceptable for this very important drug. The data on ibuprofens available in the literature were collected, combined with our complementary experimental results and evaluated. The enthalpies of combustion and formation of the crystalline RS‐(±)‐ and S‐(+)‐ibuprofens were measured using high‐precision combustion calorimetry. The temperature dependence of the vapour pressure of S‐(+)‐ibuprofen was measured using the transpiration method and the enthalpy of vaporisation was derived from this measurement. The enthalpies of fusion of both compounds were measured using DSC. The G4 calculations have been carried out to determine the enthalpy of formation in gaseous state of the most stable conformer. Thermochemical properties of studied compounds were evaluated and tested for consistency with the “centerpiece approach”. A set of reliable and consistent values of thermodynamic properties of ibuprofens at 298.15 К was recommended for thermochemical calculations of the pharmaceutic processes. The diagnostic protocol was developed to distinguish the “sick” or “healthy” thermodynamic data. This diagnostic is also applicable to other drugs with a different structure than ibuprofen.

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Effect of ibuprofen entrapment procedure on physicochemical and controlled drug release performances of chitosan/xanthan gum polyelectrolyte complexes

Cited by 25 publications

References 55 publications

Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as carriers for oral delivery of ibuprofen

Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as carriers for oral delivery of ibuprofen

Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen

Quantum Chemistry and Pharmacy: Diagnostic Check of the Thermochemistry of Ibuprofen

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