Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen

Li, Chen; Wang, Ke; Xie, Dong

doi:10.3389/fchem.2021.767923

Cited by 9 publications

(1 citation statement)

References 30 publications

(30 reference statements)

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“…The release results are in agreement with the high swelling ratio of the hydrogel, with the swelling equilibrium being attained in the first 2 h (see Figure 4C). The release rate of ibuprofen was higher compared to chitosan-ibuprofen aerogels, where the drug was introduced before the freezing and lyophilization of the chitosan solution [54]. The hydrogels in the swollen state were relatively soft and elastic, with compression moduli between 80 and 140 kPa (Table 1).…”

Section: Preparation and Characterization Of The Composite Hydrogels ...mentioning

confidence: 99%

Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing

Popescu,

Constantin,

Solcan

et al. 2023

Gels

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The wound healing process is often slowed down as a result of complications from bacterial infections and inflammatory reactions. Therefore, it is necessary to develop dressings with fast antibacterial and anti-inflammatory activity that shorten the wound healing period by promoting cell migration and proliferation. Chitosan (CS)-based hydrogels have been widely studied for their antibacterial and wound healing capabilities. Herein, we developed a composite hydrogel based on CS and PVA embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent. The hydrogel prepared by double physical cross-linking, with oxalic acid and by freeze–thawing, loaded with 0.225 wt.% AgNPs and 0.264 wt.% Ib, displayed good mechanical properties (compressive modulus = 132 kPa), a high swelling degree and sustained drug delivery (in simulated skin conditions). Moreover, the hydrogel showed strong antibacterial activity against S. aureus and K. pneumoniae due to the embedded AgNPs. In vivo, this hydrogel accelerated the wound regeneration process through the enhanced expression of TNF alpha IP8, by activating downstream cascades and supporting the healing process of inflammation; Cox2, which enhances the migration and proliferation of cells involved in re-epithelialization and angiogenesis; MHCII, which promotes immune cooperation between local cells, eliminating dead tissue and controlling infection; the intense expression of Col I as a major marker in the tissue granulation process; and αSMA, which marks the presence of myofibroblasts involved in wound closure and indicates ongoing re-epithelialization. The results reveal the potential healing effect of CS/PVA/AgNPs/Ib hydrogels and suggest their potential use as wound dressings.

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Section: Preparation and Characterization Of The Composite Hydrogels ...mentioning

confidence: 99%

Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing

Popescu,

Constantin,

Solcan

et al. 2023

Gels

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Photocrosslinkable hydrogel of ibuprofen‐chitosan methacrylate modulates inflammatory response

Guan,

Yao,

2024

J Biomedical Materials Res

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Methacrylated biopolymers are unique and attractive in preparing photocrosslinkable hydrogels in biomedical applications. Here we report a novel chitosan (CS) derivative‐based injectable hydrogel with anti‐inflammatory capacity via methacrylation modification. First, ibuprofen (IBU) was conjugated to the backbone of CS by carbodiimide chemistry to obtain IBU‐CS conjugate, which converts water‐insoluble unmodified CS into water‐soluble IBU‐CS conjugate. The IBU‐CS conjugate did not precipitate at the pH of 7, which was beneficial to subsequent chemical modification with methacrylic anhydride to prepare IBU‐CS methacrylate (IBU‐CS‐MA) with significantly higher methacrylation substitution. Photocrosslinkable in situ gel formation of injectable IBU‐CS‐MA hydrogel was verified using lithium phenyl‐2,4,6‐trimethylbenzoylphosphinate (LAP) initiator under visible light. The IBU‐CS‐MA hydrogel showed good cytocompatibility as revealed by encapsulating and in vitro culturing murine fibroblasts within hydrogels. It promoted macrophage polarization toward M2 phenotype, as well as downregulated pro‐inflammatory gene expression and upregulated anti‐inflammatory gene expression of macrophages. The hydrogel also significantly reduced the reactive oxygen specifies (ROS) and nitrogen oxide (NO) produced by lipopolysaccharides (LPS)‐stimulated macrophages. Upon subcutaneous implantation in a rat model, it significantly mitigated inflammatory responses as shown by significantly lower inflammatory cell density, less cell infiltration, and much thinner fibrous capsule compared with CS methacrylate (CS‐MA) hydrogel. This study suggests that IBU‐CS conjugate represents a feasible strategy for preparing CS‐based methacrylate hydrogels for biomedical applications.

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Sodium Alginate Hydrogel Carrier with Calcium Carbonate as Calcium Source for Ibuprofen Release

Lin,

Shi,

Meng

et al. 2023

Macro Chemistry & Physics

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Sodium alginate (SA) hydrogels crosslinked by calcium carbonate (CaCO3) and gluconolactone (GDL) were prepared, and were characterized by X‐ray diffraction (XRD) analysis and Fourier transform infrared (FTIR) spectrometer. The morphologies of the gel were observed with scanning electron microscopy (SEM). The SA hydrogels were used as carrier of the anti‐inflammatory drug IBU. The effects of GDL content, pH value and temperature on IBU release behavior were investigated and associated kinetic analysis was performed. The results showed that the cumulative release of IBU showed a trend of increasing and then decreasing with GDL content increased. The maximum cumulative release was observed when the molar ratio of Ca2+ in CaCO3 to GDL was 0.6. The release behavior of IBU was observed to have been influenced by pH levels, and it exhibited an optimal release trend at a pH value of 7.4. The impact of temperature on the release behavior of IBU was relatively insignificant compared to other factors. The Korsmeyer‐Peppas release kinetic model was well fitted, and suitable to explain the release behavior of IBU from the sodium alginate hydrogel.This article is protected by copyright. All rights reserved

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Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen

Cited by 9 publications

References 30 publications

Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing

Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing

Photocrosslinkable hydrogel of ibuprofen‐chitosan methacrylate modulates inflammatory response

Sodium Alginate Hydrogel Carrier with Calcium Carbonate as Calcium Source for Ibuprofen Release

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