2007
DOI: 10.1016/j.neuroscience.2007.02.067
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Effect of hypoxia on the morphology of mouse striatal neurons

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Cited by 10 publications
(15 citation statements)
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“…Processes can leave the cell body or be branches from dendrite. Knowledge of the standard pyramidal cell shape indicates two levels to measure to determine dendritic complexity (as per Irwin et al, 2002), using NeuroExplorer (as per Wallace, Hartle, Snow, Ward, & Ivanco, 2007). The complexity of basilar dendrites was analyzed up to and including 6 orders from the cell body by counting the number of branches at each order.…”
Section: Data Collectionmentioning
confidence: 99%
“…Processes can leave the cell body or be branches from dendrite. Knowledge of the standard pyramidal cell shape indicates two levels to measure to determine dendritic complexity (as per Irwin et al, 2002), using NeuroExplorer (as per Wallace, Hartle, Snow, Ward, & Ivanco, 2007). The complexity of basilar dendrites was analyzed up to and including 6 orders from the cell body by counting the number of branches at each order.…”
Section: Data Collectionmentioning
confidence: 99%
“…Early studies show that hypoxia induces swelling of mitochondria, alters synaptic transmission and inhibits protein synthesis [2][3][4]. Recent studies demonstrate a significant decrease in dendritic length in striatal medium spiny neurons (MSNs) of mice after chronic hypoxia [5], while a significant disorientation in CA1 pyramidal neurons of rat hippocampus has been found after ischemia [6]. Early studies demonstrated that the vulnerability of neurons to low oxygen varies among species and brain regions, in which mammalian neurons of the hippocampus and cortex are typical targets of hypoxia [7,8], especially in the neocortical brain regions [9].…”
Section: Introductionmentioning
confidence: 99%
“…Profound loss of pyramidal neurons in the hippocampus, striatial neurons and Purkinje cells in the cerebellum is documented (Wallace et al, 2007;Zaidi, 2010aZaidi, , 2010bChurilova et al, 2012) since these brain regions are highly vulnerable to oxidative attack (Cervos-Navarro and Diemer, 1991). Our study however, revealed substantial morphological changes in the other brain parts too, namely medulla oblongata, thalamus, mesencephalon and pons.…”
Section: Discussionmentioning
confidence: 99%
“…Morphometrical analyses did not show enhanced number of microvessels, however the smallest capillaries were dilated by 5-6%, which caused an increase of the blood vessels area of 0.6% on average. In fact, angiogenesis is shown to be the long-term effect of hypoxia (Wallace et al, 2007). Vasodilation in response to hypoxia is a fundamental physiologic response that improves perfusion and oxygen supply of the affected tissue.…”
Section: Discussionmentioning
confidence: 99%
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