Effect of acute hypoxic shock on the rat brain morphology and tripeptidyl peptidase I activity

Petrova, Emilia; Dimitrova, Mashenka; Ivanov, Ivaylo P.; Pavlova, Velichka; Dimitrova, S.; Kadiysky, D.

doi:10.1016/j.acthis.2016.05.003

Cited by 6 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the best of our many readings, it is the first time to study the cerebral-protection role of TQ for brain cancer induced by SN in rats. It has been previously published that molecular mechanism of the action of thymoquinone to remediate the pro-inflammatory mediator where TQ activates the Nrf2/ARE antioxidant mechanisms in its anti-inflammatory activity 13 . TQ inhibits lipopolysaccharide (LPS)-induced neuroinflammation through interference with NF-κB signaling 13 .…”

Section: Discussionmentioning

confidence: 99%

Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

Hamdan

Al‐Gayyar

Shams

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Continuous exposure to preservatives such as nitrite salts has deleterious effects on different organs. Meanwhile, Nigella sativa oil can remediate such organ dysfunction. Here, we studied the effect of consumption of thymoquinone (TQ); the main component of Nigella sativa oil on the brain damage induced by sodium nitrite. Forty adult male rats were daily given oral gavage of sodium nitrite (80 mg/kg) with or without thymoquinone (50 mg/kg). Oxidative stress, cytokines of inflammation, fibrotic elements and apoptotic markers in brain tissue were measured. Exposure to sodium nitrite (SN) resulted in increased levels of malondialdehyde, TGF-β, c-reactive protein, NF-κB, TNF-α, IL-1β and caspase-3 associated with reduced levels of glutathione, cytochrome c oxidase, Nrf2 and IL-10. However, exposure of rats’ brain tissues to thymoquinone resulted ameliorated all these effects. In conclusion, thymoquinone remediates sodium nitrite-induced brain impairment through several mechanisms including attenuation of oxidative stress, retrieving the reduced concentration of glutathione, blocks elevated levels of pro-inflammatory cytokines, restores cytochrome c oxidase activity, and reducing the apoptosis markers in the brain tissues of rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

Hamdan

Al‐Gayyar

Shams

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In this regard, the study of the morphological criteria of organs, including the brain, at different times of the postmortem period has not lost its relevance. Morphological manifestations of autolysis in the brain are described [8]. Autolysis in the brain tissue is manifested by diffuse karyolysis (paling and loss of clarity of the core contours until complete disappearance), chromatolysis (paling and dissolution of the Nissl substance) and cytolysis (similar changes in the cytoplasm).…”

Section: -28 Hoursmentioning

confidence: 99%

The State of the Structure of the Brain Cortex at Different Times of the Postmortal Period after Massive Blood Loss and Blood Loss Complicated by Hemorrhagic Shock

Eshmamatovich

Indiaminovich

2021

JAMMR

View full text Add to dashboard Cite

Determine the time of death based on these characteristics. Aims: The aim of the study was to identify the features of changes in the structure of the cerebral cortex in different periods of the post - mortem period after massive blood loss and blood loss complicated by hemorrhagic shock, and to determine the age of death based on these data. Study Design: Cross-sectional study. Place and Duration of Study: Department of Medicine and Department of Forensic Medicine 2020 between. Methodology: The structures of the cortex from the Brodman sixth field of the large hemispheres of the brain were studied from 73 corpses of individuals who died from massive blood loss (MB) - 61 and blood loss complicated by hemorrhagic shock -12. The study of corpses with MB (group 1) was carried out in the period: 6-8 h (26), 8-10 h (6), 10-12 h (4), 12-14 h (6), 14-16 h ( 12), 16-24 h (5), 24-28 h (2) postmortem period. Research of corpses after hemorrhagic shock (group 2) were carried out after 6-8 hours (3), 12-14 (3), 18-20 (2), 24-28 (4). Histological preparations of the brain were first examined qualitatively, then quantitatively. Quantitative study of structures was carried out by the point method according To G. G. Avtandilov, the digital material was statistically processed by the Student – Fisher method. Results: Thus, at death from massive blood loss, as the post-mortem period increases, there is an increase in structural changes in cortical neurons,as well as an expansion of pericellular space. The vascular component of the cerebral cortex is also involved in destructive processes associated with an increase in the postmortem period, and an increase in perivascular spaces is observed. Conclusion: Comparative analysis of the data obtained showed that in the postmortem period after hemorrhagic shock (group 2), destructive changes in the cerebral cortex appear earlier and are more pronounced than in the case of death from massive blood loss (group 1). Similar expansion of perineuronal and perivascular spaces in the cerebral cortex reflects the persistence of thanatogenesis manifestations in different periods of the post-mortal period after death from massive blood loss and hemorrhagic shock.

show abstract

Tripeptidyl Peptidase I and Its Role in Neurodegenerative and Tumor Diseases

Dimitrova

Atanasova

Lazarov

2017

Pathophysiological Aspects of Proteases

View full text Add to dashboard Cite

Effect of acute hypoxic shock on the rat brain morphology and tripeptidyl peptidase I activity

Cited by 6 publications

References 34 publications

Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives

The State of the Structure of the Brain Cortex at Different Times of the Postmortal Period after Massive Blood Loss and Blood Loss Complicated by Hemorrhagic Shock

Tripeptidyl Peptidase I and Its Role in Neurodegenerative and Tumor Diseases

Contact Info

Product

Resources

About