Effect of hypogeomagnetic field on tissue and intracellular reorganization of mouse myocardium

Nepomnyashchikh, L. M.; Лушникова, Е. Л.; Клинникова, М. Г.; Молодых, О. П.; Ashcheulova, N. V.

doi:10.1007/bf02446851

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…Mn SOD is located in the mitochondrial matrix (Zhu and Scandalios, 1995 ). It has been shown that mitochondrion is sensitive to the HMF (Fu et al, 2016 ; Belyavskaya, 2004 ; Nepomnyashchikh et al, 1997 ). Based on our data, no significant difference was detected on the expression and activity of Mn-SOD between the GMF and HMF groups; while the denaturation of CuZn-SOD was directly accelerated by the HMF in the solution, a cell-free condition.…”

Section: Discussionmentioning

confidence: 99%

“…Mitochondria is closely related to the regulation of reactive oxygen species (ROS) (He et al, 2016 ), which has been proposed as the organelle most sensitive to environmental magnetic field (Belyavskaya, 2004 ). The HMF inhibits mitochondrial function in mouse myocardium and primary muscle cells (Fu et al, 2016 ; Nepomnyashchikh et al, 1997 ). By using transcriptome profiling, we found that the differentially expressed genes in the HMF-exposed human neuroblastoma SH-SY5Y cells were involved in the process of metabolism and oxidative stress (Mo et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase

Zhang

et al. 2017

Protein Cell

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Accumulative evidence has shown the adverse effects of a geomagnetic field shielded condition, so called a hypomagnetic field (HMF), on the metabolic processes and oxidative stress in animals and cells. However, the underlying mechanism remains unclear. In this study, we evaluate the role of HMF on the regulation of cellular reactive oxygen species (ROS) in human neuroblastoma SH-SY5Y cells. We found that HMF exposure led to ROS decrease, and that restoring the decrease by additional H2O2 rescued the HMF-enhanced cell proliferation. The measurements on ROS related indexes, including total anti-oxidant capacity, H2O2 and superoxide anion levels, and superoxide dismutase (SOD) activity and expression, indicated that the HMF reduced H2O2 production and inhibited the activity of CuZn-SOD. Moreover, the HMF accelerated the denaturation of CuZn-SOD as well as enhanced aggregation of CuZn-SOD protein, in vitro. Our findings indicate that CuZn-SOD is able to response to the HMF stress and suggest it a mediator of the HMF effect.Electronic supplementary materialThe online version of this article (doi:10.1007/s13238-017-0403-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase

Zhang

et al. 2017

Protein Cell

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“…In particular, HMC caused an increase in heart rate in Danio renio fish embryos [48]. In mice, changes in the tissue and cellular structure of the myocardium occur [84].…”

Section: Cardiovascular System and Immunitymentioning

confidence: 98%

“…Suppression of the innate immune system should also be expected [82]. Changes in the cardiovascular system are also possible, and changes may affect the architecture of the heart tissue itself [44,84]. On the part of the central nervous system, architectural changes may also occur caused by a slowdown in neuronal differentiation [107].…”

Section: Potential Effects Of Hmc On Organisms Depending On Inductionmentioning

confidence: 99%

Hypomagnetic Conditions and Their Biological Action (Review)

Sarimov,

Serov,

Gudkov

2023

Biology

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The geomagnetic field plays an important role in the existence of life on Earth. The study of the biological effects of (hypomagnetic conditions) HMC is an important task in magnetobiology. The fundamental importance is expanding and clarifying knowledge about the mechanisms of magnetic field interaction with living systems. The applied significance is improving the training of astronauts for long-term space expeditions. This review describes the effects of HMC on animals and plants, manifested at the cellular and organismal levels. General information is given about the probable mechanisms of HMC and geomagnetic field action on living systems. The main experimental approaches are described. We attempted to systematize quantitative data from various studies and identify general dependencies of the magnetobiology effects’ value on HMC characteristics (induction, exposure duration) and the biological parameter under study. The most pronounced effects were found at the cellular level compared to the organismal level. Gene expression and protein activity appeared to be the most sensitive to HMC among the molecular cellular processes. The nervous system was found to be the most sensitive in the case of the organism level. The review may be of interest to biologists, physicians, physicists, and specialists in interdisciplinary fields.

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