Electromagnetic effects – From cell biology to medicine

Funk, Richard; Monsees, Thomas K.; Özkucur, Nurdan

doi:10.1016/j.proghi.2008.07.001

Cited by 343 publications

(289 citation statements)

References 366 publications

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“…Namely, low penetration of EHF EMR through biological tissues [4,5] needs explanation. Most probable hypothesis is confined to the role played by magnetic field -sensitive molecules, which are involved in the receptor sensitivity control of those neuromodulative systems which are involved in the control of neuronal brain excitability.…”

Section: Discussionmentioning

confidence: 99%

“…The anti-epileptic effect may be based on the EHF radiation ability to increase the tone of serotonergic, opioid, noradregenic and neuromodulator systems [1,4], as well as histaminergic central mechanisms [5], the activation of which leads to suppression of convulsive activity of the brain [3,7,10]. EHF EMR provides significant anti-inflammatory effect, which manifests both in local [5] and systemic inflammation process [8].…”

Section: Introductionmentioning

confidence: 99%

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Antiepileptic effects of short-wave radiation in hypogeomagnetic conditions

et al. 2013

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AbstractThe work was dedicated to investigation of dynamics of epileptic activity in conditions of extremely high frequency electromagnetic waves (EHF) radiation (7,1 mm, 0,1 mW/cm2) upon focal epileptic activity. Epileptic activity was penicillin-induced (10,000 IU/ml) in the frontal region of the brain cortex in myorelaxed and artificially ventilated rats under acute experimental condition. Thermal effects were absent as far as absorbed dosage of energy did not exceed 0,1 J/ animal. It was established that preliminarily performed hypogeomagnetic period (3,0 h) with the inductivity of geomagnetic field at 5×10−8 Tesla caused the intensification of antiepileptic effects of EHF (15,0 min of exposure). It was pronounced in the form of decrease of foci intensity and significant reduction of lifespan of foci — up to 115,3±13,4 minutes, which was both significant when compared with separate effects of hypogeomagnetic influence (187,3±12,5 min) and EHF (15,0 minutes of exposure) effect (164,2±12,5 minutes) (P<0,05). Besides, EHF (15,0 min) which was made after 3,0 h exposure to hypogeomagnetic influence suppressed generalized seizures in amygdalarly kindled rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiepileptic effects of short-wave radiation in hypogeomagnetic conditions

et al. 2013

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“…These electric field gradients ("bioelectricity") are not only created by small ions but are also driven by larger biomolecules. These charge driven electric fields trigger pathways such as cell signaling, tissue factors, growth hormones, transmitters etc [1][2][3][4][5][6][7]. Since about ten years from now, new methods like membrane potential-and ion-sensitive in vivo dyes as well as constructs for imaging and molecular tracing are available, allowing a direct observation of the mentioned processes in cells, tissues and living systems.…”

Section: Equivalent Counterpart In the Organism?mentioning

confidence: 99%

“…In living organisms, electromagnetic fields are generated endogenously mostly as direct current fields (DC) or ultra-low frequency (ULF)-EMF [6]. These fields arise from the segregation of charges by molecular pumps, transporters and ion channels situated in the plasma membrane [8].…”

Section: Equivalent Counterpart In the Organism?mentioning

confidence: 99%

Does electromagnetic therapy meet an equivalent counterpart within the organism?

Funk¹

2017

J Transl Sci

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This review bundles all available new information about intrinsic electrical phenomena in many types of cells (also non-neural) and tissues and shows that exogenously applied electric fields (as DC -EF, EMF or pulsed electromagnetic fields PEMF) can couple to the endogenous electrical phenomena of the body. These endogenous fields are generated ubiquitously in all tissues via cellular ion pumps and transporters and these ion gradients can be transferred by gap junctions. Such electric phenomena can now be monitored in living cells and tissues by electro-sensitive markers. Observations are now available from early embryonic development on to wound healing and regeneration within the adult organism. Based on these grounds we demonstrate that endogenous electric fields act directly on classical pathways of molecular and cell biology. Adequately applied frequencies and pulsing from outside can couple to these endogenous fields or to the receptors of classical biochemical pathways and manifest in positive "reprogramming" of tissue functions. In sum, this new analytical approach to the bodies´ own electrical information processes opens up new avenues for adequate EMF and PEMF therapy.

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“…A variety of central nervous system disorders, such as nervousness, anxiety, sleep disturbances and stress have been reported to occur in human population when exposed to magnetic field (Akerstedt et al 1998;Jadidi et al 2007;Funk et al 2009), which has been attracting increased public interest. Previous epidemiological surveys conducted on human exposure to extremely low frequency (ELF) electromagnetic fields (EMF) have implicated that ELF-EMF causes several health disorders in humans, such as various types of brain cancers, depression and suicide, neurodegenerative, cardiovascular and reproductive diseases (Central Power Research Institute Report 2000;Ahlbom et al 2001;World Health Organization Report, 2007;Schuz and Ahlbom 2008;Kheifets et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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Abstract. The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 µT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum > hippocampus > cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus > cerebellum > cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 µT than at 50 µT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions.

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Electromagnetic effects – From cell biology to medicine

Cited by 343 publications

References 366 publications

Antiepileptic effects of short-wave radiation in hypogeomagnetic conditions

Antiepileptic effects of short-wave radiation in hypogeomagnetic conditions

Does electromagnetic therapy meet an equivalent counterpart within the organism?

Extremely low frequency magnetic fields induce oxidative stress in rat brain

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