Effect of Hyperventilation on Oxygenation of the Brain Cortex of Neonates

Wilson, David F.; Pastuszko, Anna; Schneiderman, Roy; DiGiacomo, J. E.; Pawłowski, M.; Delivoria‐Papadopoulos, Maria

doi:10.1007/978-1-4615-3404-4_39

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Cited by 8 publications

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“…Considering the known effects of severe hyperventilation on cerebral tissue oxygenation (reduction of oxygen pressure in cerebral tissue from 40 to 10 mmHg) (19)(20)(21) and metabolism (increased lactate production, anaerobic glycolyses) (20,22,23), a decrease in CtO 2 can be expected, which is a proven re-sult in hyperventilated animals (12). Although there was a trend in CtO 2 to confirm these assumptions, statistical analyses obtained no significance in our results.…”

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confidence: 99%

“…Systemic hypocapnia is known to impair cerebral oxygen delivery by decreasing cerebral blood flow (CBF), which will be compensated for by an increased extraction rate of oxygen followed by an increase in deoxygenated haemoglobin in cerebral venous vessels (17,18). Furthermore, severe systemic hypocapnia reduces the oxygen pressure in cerebral tissue (19)(20)(21) extensively enough to induce anaerobic glycolysis and lactate production in cerebral cells (20,22,23).…”

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