Effect of hydrolysable tannin on nutrient intake obesity and other associated metabolic risk factors in polycystic rats

Abstract

Background Food intake and eating behavior are two important risk factors that lead to obesity and other associated metabolic and reproductive disorders like polycystic ovarian syndrome (PCOS). Most of the phytonutrients like hydrolysable tannin (HT) have the ability to reduce the nutrient intake that might be a suitable remedy for weight management of females in their reproductive age. Therefore, the present research is aimed to find out the effect of HT on nutrient intake, weekly body weight, blood glucose, serum lipids, minerals, immunoglobulins and satiety hormones in PCOS rats. Materials and methods A total of forty five adult healthy female rats of 56 days old, weighed 135 ± 5 g with two consecutive estrous cycles were selected. In order to induce PCOS in rats, the intramuscular injection of 4 mg/rat/kg Estradiol- Valerate was used. After induction, a Complete Randomized Design was used to divide the rats into five equal groups (n = 9) named as Pc0, Pc0.5, Pc1, Pc1.5 and Pc2. The groups of rats were offered different doses of HT i.e. 0, 0.5, 1, 1.5 and 2 % respectively per kg body weight in solution form through oral gavage once in a day for 60 days. Results After the intake of different levels of HT, the statistical results had shown a significant decrease (p < 0.05) in the weekly nutrient intake, body weight, water intake, weight gain, fasting blood glucose in PCOS rats. A similar trend of decrease (p < 0.05) was noticed in serum iron, IgM, IgG, leptin, ghrelin, cholesterol, low density lipoprotein and triglycerides while a significant improvement (p < 0.05) was also observed in high density lipoprotein in the PCOS rats. However, a non-significant effect (p > 0.05) was observed on serum protein and calcium levels. Conclusions The study concluded that HT had a therapeutical potential to decrease the nutrient intake and its anti-nutritional property could be used as remedy for the management of body weight, hyperglycemia, dyslipidemia and cardiovascular risk factors of PCOS rats.

Effects of Fagonia indica on Letrozole-Induced Polycystic Ovarian Syndrome (PCOS) in Young Adult Female Rats

“…Previously, increased oxidative status has been determined in the systemic circulation and follicular fluids of PCOS rats [ 39 ]. Imbalanced reproductive hormones and insulin resistance is the key characteristics in PCOS patients and were responsible for the imbalance in energy homeostasis, development of adiposity, and weight gain [ 40 ].…”

Elateriospermum tapos Yogurt Supplement in Maternal Obese Dams during Pregnancy Modulates the Body Composition of F1 Generation

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“…Previous studies have shown that tannins could lower cholesterol, triglyceride, LDL, and increase HDL levels in obese rats. In addition, tannins could reduce ghrelin activity, which regulates hunger to regulate food intake and reduce body weight (Manzoor et al, 2021;Panche et al, 2016). Alkaloid mechanisms in losing weight include suppressing lipogenesis, suppressing leptin expression, and sterol regulatory element-binding protein-1c (SREBP-1c).…”