Effect of hyaluronic acid on the osseointegration of dental implants

Yazan, Murude; Koçyiğit, İsmail; Atıl, Fethi; Tekin, Umut; Gönen, Zeynep Burçin; Önder, M. Ercüment

doi:10.1016/j.bjoms.2018.08.014

Cited by 15 publications

(18 citation statements)

References 10 publications

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“…HLA may act as a biomimetic scaffold for other molecules, such as BMP-2 and TGF-β. 13,14 Current study revealed more collagen and crystal maturity in HLA treated sites especially at 6 weeks as mentioned before.…”

Section: Discussionsupporting

confidence: 70%

“…The higher the MW was, the higher rate of bone formation. 14,17,23 Many researchers evaluated HLA effects on bone healing. It increased the expressions of bone matrix components (Alkaline phosphatase ALP, and Osteopontain OCN).…”

Section: Discussionmentioning

confidence: 99%

“…13 Moreover, Yazan et al demonstrated HLA bone induction by stimulating (UMC) around dental implant in rabbit's mandibular molar area. 5,14 HLA levels are dramatically elevated immediately after tooth extraction. It aids both soft tissue and bone healing.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the effect of hyaluronic acid and chitosan biocomposite natural polymers in alveolar ridge preservation: an experimental study in dogs

Behairy

Hammad

Ahmed

et al. 2019

Egyptian Dental Journal

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Alveolar ridge preservation procedures became a famous procedures after tooth extraction. Different approaches and materials had been studied. Faster and new bone formation is the concept. Objective: To evaluate the early stages of alveolar bone healing of tooth extraction sockets filled with bioactive composite (chitosan-bioactive glass) CH-MB scaffold soaked in hyaluronic acid (HAL) in a canine model. Materials and Methods: Six mongrel dogs were involved in this study; they were divided into two groups according to sacrifice time (three and six weeks). Each of these groups includes three animals. Animals were subjected to extraction of the third premolar bilaterally. The right extraction socket received bioactive composite (chitosan-bioactive glass) CH-MB scaffold soaked in 0.2 % hyaluronic acid, while the left side had received chitosan-bioactive glass scaffold CH-MB only. The healing extraction sockets were evaluated by (Fourier Transfer Infra-Red spectroscopy) FTIR; where three variables were studied: Matrix quality, degree of crystallinity and degree of calcifications. Results: Hyaluronic acid (HLA) treated groups showed significant results at 6 weeks over all other groups as regard collagen content and crystal maturity. While, degree of calcification showed non-significant results. Moreover, HLA groups showed significant increase from 3 weeks to 6 weeks over non treated groups. Conclusion: Hyaluronic acid was effective in extraction socket healing as regard collagen content at 3 and 6 weeks and crystal maturity especially at 6 weeks. While degree of calcification was negatively affected. It was postulated that HLA sustained its release on the biocomposite scaffold for 6 weeks postoperatively.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Evaluation of the effect of hyaluronic acid and chitosan biocomposite natural polymers in alveolar ridge preservation: an experimental study in dogs

Behairy

Hammad

Ahmed

et al. 2019

Egyptian Dental Journal

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“…An example of the roughness profile for CpTi G4 substrate subjected to sandblasting and autoclaving and ECAD-derived ACP coating is shown in Figure 2. The osseointegration process depends on many factors, including the quality of the bone, biocompatibility, and surface roughness of dental implants with Ra between 1 and 3 [36]. The arithmetic average height parameter, defined as the average absolute deviation of the roughness irregularities from the mean line over one sampling length, was almost The osseointegration process depends on many factors, including the quality of the bone, biocompatibility, and surface roughness of dental implants with Ra between 1 and 3 [36].…”

Section: Surface Roughness Studymentioning

confidence: 99%

“…The osseointegration process depends on many factors, including the quality of the bone, biocompatibility, and surface roughness of dental implants with Ra between 1 and 3 [36]. The arithmetic average height parameter, defined as the average absolute deviation of the roughness irregularities from the mean line over one sampling length, was almost The osseointegration process depends on many factors, including the quality of the bone, biocompatibility, and surface roughness of dental implants with Ra between 1 and 3 [36]. The arithmetic average height parameter, defined as the average absolute deviation of the roughness irregularities from the mean line over one sampling length, was almost 1.5-times larger for the ACP coating ( Figure 2b) than that determined for the titanium substrate (Figure 2a), and equaled 1.91(11) µm and 2.81(8) µm, respectively.…”

Section: Surface Roughness Studymentioning

confidence: 99%

Long-Term Assessment of the In Vitro Corrosion Resistance of Biomimetic ACP Coatings Electrodeposited from an Acetate Bath

Osak

Maszybrocka

Kubisztal

et al. 2021

JFB

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Calcium phosphate coatings are able to improve the osseointegration process due to their chemical composition, which is similar to that of bone tissues. In this work, to increase the long-term corrosion resistance and to improve the osseointegration process of commercially pure titanium Grade 4 (CpTi G4), biomimetic amorphous calcium phosphate (ACP) coatings were electrodeposited for the first time from an acetate bath with a pH level of 7.0 and a Ca:P ratio of 1.67. ACP coatings were obtained on CpTi G4 substrate subjected to sandblasting and autoclaving using electrochemically assisted deposition at a potential of −3 V relative to the open circuit potential for 30 min at room temperature. SEM, EDS, 2D roughness profiles, amplitude-sensitive eddy current method, and Kelvin scanning probe were used for the surface characterization of the biomaterial under study. In vitro corrosion resistance tests were conducted for 21 days in artificial saliva using open circuit potential, polarization curves, and electrochemical impedance spectroscopy measurements. The passive-transpassive behavior was revealed for the obtained ACP coatings. The long-term corrosion resistance test showed a deterioration of the protective properties for CpTi G4 uncoated and coated with ACP with immersion time. The mechanism and kinetics of the pitting corrosion on the CpTi G4|TiO2|ACP coating system are discussed in detail.

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Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review

Saleh Hasani Jebelli,

Yari,

Nikparto

et al. 2024

Cell Biochemistry & Function

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The demand for efficient and accelerated osseointegration in dental implantology has led to the exploration of innovative tissue engineering strategies. Immediate implant loading reduces treatment duration and necessitates robust osseointegration to ensure long‐term implant success. This review article discusses the current studies of tissue engineering innovations for enhancing osseointegration in immediate dental implant loading in the recent decade. Keywords “tissue engineering,” “osseointegration,” “immediate implant loading,” and related terms were systematically searched. The review highlights the potential of bioactive materials and growth factor delivery systems in promoting osteogenic activity and accelerating bone regeneration. The in vivo experiment demonstrates significantly improved osseointegration in the experimental group compared to traditional immediate loading techniques, as evidenced by histological analyses and biomechanical assessments. It is possible to revolutionize the treatment outcomes and patient satisfaction in dental implants by integrating bioactive materials and growth factors.

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Effect of hyaluronic acid on the osseointegration of dental implants

Cited by 15 publications

References 10 publications

Evaluation of the effect of hyaluronic acid and chitosan biocomposite natural polymers in alveolar ridge preservation: an experimental study in dogs

Evaluation of the effect of hyaluronic acid and chitosan biocomposite natural polymers in alveolar ridge preservation: an experimental study in dogs

Long-Term Assessment of the In Vitro Corrosion Resistance of Biomimetic ACP Coatings Electrodeposited from an Acetate Bath

Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review

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