Effect of Hormone Therapy on Mitogenic Responses of Lymphocytes From Patients With Cancer of the Breast

Immune competence in breast cancer ? Relationship of pretreatment immunologic tests to diagnosis and tumor stage

“…Whittaker et al (1971) found reduced responses which they attributed to factors in the autologous cancer serum as this reduction could be abrogated by exchanging normal homologous serum for the autologous serum. However, Pentycross et al (1973) using homologous serum, found a significant impairment of response in a series of 93 breast cancer patients, suggesting an intrinsic lymphocyte abnormality. Their results were not considered in relation to tumor stage.…”

Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]-dichloroplatinum (II) Act on the Hormone-Sensitive, Murine Breast Cancer as a Biological Response Modifier? Part II. Studies on the Influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the Specific Immune Defense in MXT-M-3,2 Breast Cancer Bearing Mice

“…of action, which is based on their hormonal potency [1,2] . Indications that estrogens can modify the immune response in patients [5,[11][12][13][14][16][17][18][19] induced us to examine, if meso-1-PtCl 2 brings about its anti-breast cancer activity in rodents by enhancement of the body defense. To this end we studied the influence of splenectomy and of cyclosporine A co-administration, respectively, on the activity of meso-1-PtCl 2 on the ER + murine breast cancer.…”

“…It was supposed that in this process the stimulation of the phagocytic activity of granulocytes and monocytes/macrophages by estrogens plays an important role [12] . Furthermore, it was shown that estrogen administration can stimulate Tlymphocyte activity in breast cancer patients previously submitted to surgery or to radiation therapy [17] . A reappraisal of estrogen therapy in a small study also demonstrated the…”

Oestrogen Therapy and Serum Cortisol in Carcinoma of the Prostate

“…Moreover, castration in the experimental animal produces marked changes in humoral immune reactivity which may be enhanced further by the addition of adrenalectomy (Eidinger and Garrett, 1972). Equally extensive is the evidence pointing to significant alterations in cell-mediated immunity following oestrogen administration; several in vitro studies have shown a depressed lymphocyte response to mitogens in humans receiving exogenous oestrogens (Hagen and Froland, 1972;Fitzgerald, Pickering and Fergusson, 1973;Pentycross et a/., 1973). A similar situation has been found in pregnant women (Purtillo, Hallgren and Yunis, 1972).…”