Immune competence in breast cancer ? Relationship of pretreatment immunologic tests to diagnosis and tumor stage

Bolton, P.M.; Teasdale, C.; Mander, Ann; James, Susan; Davidson, J.; Whitehead, Robert H.; Newcombe, Robert G.; Hughes, L. E.

doi:10.1007/bf00200101

Cited by 30 publications

(2 citation statements)

References 26 publications

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“…= non significant A reduced skin reactivity to recall as well to primary antigens has been correlated with the extent of the malignant disease. Our present study confirms what has been described for pa tients with breast, lung, head and neck and gastrointestinalcancer and also with cervical cancer i.e., a significant lower re sponse rate to DNCB in the advanced clinical stages [17][18][19].…”

Section: Discussionsupporting

confidence: 81%

Investigations on General Immune Reactivity in Untreated Cervical Cancer Patients

Micksche¹,

Luger²,

Michalica³

et al. 1978

Oncology

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74 patients with untreated cervical cancer (FIGO II and III) were skintested with a battery of recall antigens, and also sensitised and challenged with DNCB. A significant reduction of reaction to Tuberkulin, Varidase and also to DNCB was found in patients with stage III in comparison to healthy females of the same age group. Significant changes in immunoglobulin levels, increase of IgA and decrease of IgG were ovserved in the cancer patients. Serum lysozyme values were the same as in the control group.

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Section: Discussionsupporting

confidence: 81%

Investigations on General Immune Reactivity in Untreated Cervical Cancer Patients

Micksche¹,

Luger²,

Michalica³

et al. 1978

Oncology

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“…Παρακάτω συγκρίνονται τά ευρήματα στους ασθενείς μέ καλοήθη νόσο τοΰ στομάχου μέ αυτών πού είχαν κακοήθη νόσο (πίνακαςί 2) καί αναγράφεται ή στα τιστική άξιολόγησις τούτων. Παρατηρούμε στον πίνακα 12 Στον άλλο πίνακα (πίνακας 13) συγκρίνονται τά αποτελέσματα τών ασθενών μέ καλοήθη πάθηση τοϋ στομάχου μέ αυτά τών ασθενών μέ κακοήθη πάθηση τοΰ στομάχου χωρίς μεταστάσεις. Στον τρίτο πίνακα (πίνακα 14) συγκρίνονται τά απο τελέσματα τών ασθενών μέ καλοήθη πάθηση τοϋ στομάχου μέ αυτά άπό τους ασθενείς μέ προχωρημένη νεοπλασία τοΰ στομάχου.…”

Section: κεφαλαιο 3οunclassified

Συμβολη Στη Διαγνωση Του Καρκινου Με Τη Μελετη Της Μορφολογιας Των Πυρηνισκων Των Λεμφοκυτταρων Του Περιφερικου Αιματος

Αξιωτησ¹

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Immunocompetence, immunosuppression, and human breast cancer. II. Further evidence of initial immune impairment by integrated assessment effect of nodal involvement (N) and of primary tumor size (T)

Adler¹,

Stein

Ben-Efraim

1980

Cancer

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Comprehensive immune function by integrated score was assessed in 158 operable, 55 inoperable, and 52 metastatic breast cancer patients relative to 107 healthy controls. The score was derived from in vivo response to PPD and DNCB and in vitro lymphocyte stimulation by PPD and PHA. Proportion of E-RFC was significantly lower in patients than in controls but was not found to correlate directly with the above functional criteria. Fifty-one percent of the patients with early, operable tumors were shown to be at least partially immunosuppressed by integrated score achievement vs. 11% of controls. This proportion rises to 68% of inoperable and 89% of metastatic patients. Quantitative analysis by graded response revealed an additional, significant degree of immune impairment in the respective patient groups by all testing parameters. Depression of immune function in operable patients was not related to age nor influenced by surgery. Immunocompetence of patients with mammary dysplasia did not differ from controls. Increasing size of primary tumor (T) was not found to be matched by progressive degree of immunosuppression, excepting that associated with large T4 tumors. Patients with lymph node involvement (N+) were not significantly immunologically inferior to those without (No) where the larger operable T2-:, tumors are concerned. In the smallest, T, tumors, nodal involvement (N +) is accompanied by remarkable immnnosuppres-sion relative to T,No cases. This finding suggests a pre-existing immune defect inherent in TIN+ patients. It supports the hypothesis that the immunosuppression associated with early breast cancer is primary, patient related, Secondary tumor-induced depression of immune response characterizes advanced and metastatic human breast cancer.

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Immune competence in breast cancer ? Relationship of pretreatment immunologic tests to diagnosis and tumor stage

Abstract: Summary. The

Cited by 30 publications

References 26 publications

Investigations on General Immune Reactivity in Untreated Cervical Cancer Patients

Investigations on General Immune Reactivity in Untreated Cervical Cancer Patients

Συμβολη Στη Διαγνωση Του Καρκινου Με Τη Μελετη Της Μορφολογιας Των Πυρηνισκων Των Λεμφοκυτταρων Του Περιφερικου Αιματος

Immunocompetence, immunosuppression, and human breast cancer. II. Further evidence of initial immune impairment by integrated assessment effect of nodal involvement (N) and of primary tumor size (T)

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