Investigations on General Immune Reactivity in Untreated Cervical Cancer Patients

Micksche, M.; Luger, Thomas A.; Michalica, W; Tatra, G

doi:10.1159/000225286

Cited by 7 publications

(1 citation statement)

References 15 publications

(15 reference statements)

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“…The more advanced the neoplastic disease, the higher the degree of immunosu pression demonstrated by in vivo and in vitro tests. [1][2][3][4][5][6][7][8] The interaction between different immunocompetent cells is an essential element in the regulation of immune mechanisms. With the availability of specific monoclonal antibodies that define functionally relevant lymphocyte subsets, it is possible to study the distribution of these cells in blood.…”

Section: Introductionmentioning

confidence: 99%

Monoclonal Antibody Defined Phenotypes of Peripheral Blood Lymphocytes in Cancer of the Uterine Cervix

Pillai

Balaram

Padmanabhan

et al. 1987

American Journal of Reproductive Immunology and Microbiology

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Immunological phenotypes of lymphocytes from peripheral blood of 100 patients with different stages and histologies of cancer of the uterine cervix were analyzed using monoclonal antibodies and F(ab)2 fragments of antihuman immunoglobulin. The T lymphocyte population was decreased in advanced cases of the cancer along with a rise in the B cell numbers. The OKT4+ cells generally showed a decrease in the cancer patients in contrast to the increase shown by the OKT8+ cells. The OKT4/OKT8 ratio was altered in this cancer except in patients with stages I and IIA. In terms of histology, the poorly differentiated tumors showed a higher imbalance of the cellular composition when compared to the well-differentiated and moderately differentiated tumor-bearing patients. These findings point toward a possible alteration in the immune effector cells of these cancer-bearing patients.

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