Effect of hexavalent chromium exposure on the liver and kidney tissues related to the expression of CYP450 and GST genes of Oreochromis niloticus fish: Role of curcumin supplemented diet

Mohamed, Amany Abdel-Rahman; El-Houseiny, Walaa; El-Murr, Abdelhakeem; Ebraheim, Lamiaa L.M.; Ahmed, Amany I.; Abd‐Elhakim, Yasmina M.

doi:10.1016/j.ecoenv.2019.109890

Cited by 113 publications

(44 citation statements)

References 55 publications

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“…However, Zn may have the more deleterious effect by notably decreasing enzymatic activity even at low concentration (Fig 2). These results are in accord with other studies on antioxidative mRNA expression, which in the hepatopancreas, gills and kidney were shown to be down-regulated by exposure to Cd, Cu and Zn [15,72,73]. Contrariwise, much research has shown an increase of hepatic gene expression in relation to toxic metals exposure [74][75][76].…”

Section: Discussionsupporting

confidence: 91%

“…The concentrations used in the mesocosm water (Cu: 0.004 mg/L and 0.02 mg/L; Zn: 05 mg/L and 1.5 mg/L) match those estimated in polluted areas in Egypt [48]. However, at the proteomic level, after high Cu exposure and both low and high Zn exposure, the magnitude of hepatic activity of GST and GPx decreased, as has been reported in the liver of Nile tilapia [15,16,46]. Such changes in the antioxidative capacity in Nile tilapia could be attributed to metal ion of Cu and Zn concentration and duration of exposure [15,16,46].…”

Section: Discussionsupporting

confidence: 75%

“…The most effective antioxidative physiological defense systems are comprised of enzymes such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and Glutathione-S-Transferase (GST), which are known as biomarkers of oxidative stress [8,[12][13][14][15]. The SOD converts superoxides (O 2-) generated in peroxisomes and mitochondria to hydrogen peroxide detoxified by the CAT enzyme.…”

Section: Introductionmentioning

confidence: 99%

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The Duckweed, <em>Lemna minor</em> Modulates Heavy Metal-induced Oxidative Stress in Nile Tilapia

Abdel‐Gawad¹,

Khalil²,

Bassem³

et al. 2020

Preprint

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A two-fold integrated research study was conducted; firstly, to understand effects of copper (Cu) and zinc (Zn) on the growth and oxidative stress in Nile tilapia, Oreochromis niloticus; secondly, to study the beneficial effects of the duckweed Lemna minor L. as a heavy metal remover from wastewater. Experiments were conducted in mesocosms with and without duckweed. Tilapia fingerlings were exposed to Cu (0.004 and 0.02 mg/L) and Zn (0.5 and 1.5 mg/L) and fish fed for four weeks. We evaluated the fish growth performance, the hepatic DNA structure using comet assay, the expression of antioxidative genes (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPx and glutathione-S-transferase, GST) and GPx and GST enzymatic activity. The results showed that Zn exhibited more pronounced toxic effects than Cu. Low dose of Cu did not influence the growth whereas higher doses of Cu and Zn significantly reduced the growth rate of tilapia compared to control, but addition of duckweed prevented weight loss. Further, in the presence of a high dose of Cu and Zn, DNA damage decreased, antioxidant gene expressions and enzymatic activities increased. In conclusion, results suggest that duckweed and Nile tilapia can be suitable candidates in metal remediation wastewater assessment programs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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The Duckweed, <em>Lemna minor</em> Modulates Heavy Metal-induced Oxidative Stress in Nile Tilapia

Abdel‐Gawad¹,

Khalil²,

Bassem³

et al. 2020

Preprint

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“…Additionally, the presence of 8-OHdG is considered a biomarker of DNA damage induced by oxidative stress [ 76 ]. The most remarkable enzymes for the detoxification of ROS are CAT, SOD, and GPX; hence, assessing these biomarkers is crucial in aquatic organisms [ 77 , 78 ]. In this study, LCT and/or MTM- exposure induced oxidative damage by lowering antioxidant enzyme activity and enhancing lipid peroxidation (MDA) and DNA damage (8-OHdG) in O. niloticus .…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Role of a Taurine-Enriched Diet in Combating the Immunotoxic and Inflammatory Effects of Pyrethroids and/or Carbamates in Oreochromis niloticus

Mohamed

Rahman

Salem

et al. 2021

Animals

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Indiscriminate use of insecticides is a major concern due to its ubiquitous occurrence and potential toxicity to aquatic animals. This study investigated the adverse effects of lambda-cyhalothrin (LCT; C23H19ClF3NO3) and methomyl (MTM; C5H10N2O2S) on immune system modulations and growth performance of juvenile fishes. The supportive role of a taurine (TUR; C2H7NO3S)-supplemented diet was also evaluated. Juvenile O. niloticus fishes were exposed to LCT (0.079 µg/L), MTM (20.39 µg/L), or both in water and were fed on a basal diet only or taurine-supplemented basal diet. Exposure to LCT and MTM retarded growth and increased mortality rate. LCT and MTM reduced antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase) and innate and humoral immunity but upregulated interleukin and chemokine expressions. Moreover, exposure to LCT and MTM elevated 8-OHdG levels and increased the mortality of Oreochromis niloticus after the experimental bacterial challenge. The TUR-enriched diet enhanced antioxidant enzymes and acted as a growth promoter and anti-inflammatory agent. TUR can modify innate and adaptive immune responses. Furthermore, TUR supplementation is a beneficial additive candidate for mitigating LCT and MTM toxicities mixed with O. niloticus aquafeed.

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“…The authors Macêdo et al mentioned that hepatocyte vocalization indicates inhibition of protein synthesis, energy depletion, microtubule disintegration, or changes in substrate utilization 68 . Vacuolation indicates tissue damage and the release of hepatic enzymes due to apoptosis and RBCs membranes devastation 77 . Moreover, the degenerative process of metabolic damage could also result in hepatic vocalization 78 .…”

Section: Discussionmentioning

confidence: 99%

Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions

Ramesh

Sujitha

Anila

et al. 2020

Environmental Toxicology

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Ciprofloxacin drugs are a second‐generation fluoroquinolone highly prescribed medication against various bacterial infections in human and aquaculture practices. These drugs are chemically designed to persist in the body long enough to achieve target objectives. Extensive usage has resulted in ciprofloxacin becoming a ubiquitous contaminant in the environment. Unfortunately, the ecotoxicological profiles for ciprofloxacin are scanty. This study was aimed to assess the ecotoxicity of ciprofloxacin at environmentally relevant concentrations (1 μg/L, and 1.5 μg/L) to a cultivable fish Cirrhinus mrigala. Responses of antioxidant enzymes, histological anomalies, and inorganic ion levels were studied. SOD activity in gill, liver, and kidney tissues was elevated in ciprofloxacin‐exposed groups when compared with the control group. CAT activity was predominantly decreased in ciprofloxacin treated groups relative to the control group. GST activity in the ciprofloxacin treated groups was increased (except kidney tissues [Treatment I (1 μg/L)], and gill tissues fifteenth day) significantly (p < .05). The LPO level was elevated in the ciprofloxacin treatment groups throughout the study period (except Treatment II (1.5 μg/L) tenth day in kidney tissues). A series of histological anomalies were noticed in the gill, liver, and kidney tissues of the ciprofloxacin treated groups. Ciprofloxacin exposure caused a significant decrease of sodium, potassium, and chloride levels in the plasma of C. mrigala. A parallel among an imbalanced oxidative defense system, tissue structural changes, and alterations of plasma inorganic ions could be considered as a reliable biomarker for antibiotic toxicity study. This study could be a primary platform for further toxicity studies to understand the potential molecular impacts and adverse effects of ciprofloxacin on aquatic organisms.

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Effect of hexavalent chromium exposure on the liver and kidney tissues related to the expression of CYP450 and GST genes of Oreochromis niloticus fish: Role of curcumin supplemented diet

Cited by 113 publications

References 55 publications

The Duckweed, <em>Lemna minor</em> Modulates Heavy Metal-induced Oxidative Stress in Nile Tilapia

The Duckweed, <em>Lemna minor</em> Modulates Heavy Metal-induced Oxidative Stress in Nile Tilapia

The Antioxidant Role of a Taurine-Enriched Diet in Combating the Immunotoxic and Inflammatory Effects of Pyrethroids and/or Carbamates in Oreochromis niloticus

Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions

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