Effect of herbal extracts and supplement mixture on alcohol metabolism in Sprague Dawley-rats

Abstract

This study aimed to investigate the effect of mixture of herbal extracts and supplementary formula (FNP-C) on hangovers and antioxidant enzymes in alcohol-induced liver damage in rats. HepG2 cells were used as the experimental cells and divided into five groups: non-treated control (normal), alcohol-induced control (control), mixture of herbal extracts (FNP-B), FNP-C, and a commercial treatment of liver diseases (Livers®); inhibition of detoxification and alcohol-induced damage was confirmed in vivo. Blood alcohol and acetaldehyde concentration after alcohol consumption were measured in a timely manner; alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione (GSH), glutathione transferase (GST), and lactate dehydrogenase (LDH) levels were measured in the liver. FNP-C exhibited the highest effect. When FNP-C was administered to alcohol-induced animals, blood alcohol and acetaldehyde concentration decreased compared to FNP-B and Livers®. FNP-C reduced ADH levels and improved LDH, GSH, GST, and SOD levels. The FNP-C group was effective in preventing alcohol-induced hangovers and liver damage. Thus, FNP-C improves hangovers and increases antioxidant activity in an alcohol-induced model. Adding amino acids and vitamins to natural ingredients can potentially enhance the effect of improving hangovers.

Hangover-Relieving Effect of Ginseng Berry Kombucha Fermented by Saccharomyces cerevisiae and Gluconobacter oxydans in Ethanol-Treated Cells and Mice Model

“…Recently, many people have shown interest in natural plants and drinks that treat hangovers owing to an increase in income and quality of life [ 6 ]. Moreover, research is being conducted to identify liver-protective substances derived from natural products that are safe and have excellent antioxidant activity [ 7 , 8 ].…”

Noni fruit extract ameliorates alcohol-induced hangover symptoms by reducing the concentrations of alcohol and acetaldehyde in a Sprague Dawley rat model and a human intervention study

“…Because many people experience hangover, 10,11 hangover products derived from natural substances could be an effective strategy for relieving hangover symptoms because they have abundant antioxidants. 12 A previous study reported that many plants, fruits, and vegetables, such as Pueraria Lobata, Fructus Evodiae, Trigonela Foenum-Graecum, Hovenia Dulcis, Pyrus Pyrifolia, Mangifera Indica L., Diospyros Kaki Thunb., Thymus Vulgaris, Zingiber Officinale, Asparagus Officinalis, Oenanthe Javanica, Opuntia Ficus-Indica, and Panax Ginseng, have alcohol clearance effects by upregulating ADH and ALDH activity. 13 Noni (Morinda citrifolia L.) is a plant belonging to the Rubiaceae family and is also known as beach mulberry or cheese fruit.…”

Preparation of Pueraria lobata Root-Derived Exosome-Like Nanovesicles and Evaluation of Their Effects on Mitigating Alcoholic Intoxication and Promoting Alcohol Metabolism in Mice

“…5 Acetaldehyde, an intermediate metabolite, possesses high reactivity and exerts significant hepatotoxicity; its accumulation within the body can result in severe hangover symptoms. [34][35][36] Therefore, eliminating acetaldehyde can effectively alleviate alcohol-induced hangovers and mitigate liver toxicity. For instance, Tiaogan Jiejiu Tongluo Formula, by lowering the activity of ADH and raising the activity of ALDH, accelerates the conversion of acetaldehyde to acetic acid, alleviates the accumulation of large amounts of acetaldehyde and chronic acetaldehyde poisoning, and reduces the chronic liver injury induced by alcohol in SD rats.…”