Effect of heparin and alendronate coating on titanium surfaces on inhibition of osteoclast and enhancement of osteoblast function

Moon, Hojin; Yun, Young-Pil; Han, Choong-Wan; Kim, Min Sung; Kim, Sung Eun; Bae, Min Soo; Kim, Gyu-Tae; Choi, Yong-Suk; Hwang, Eui-Hwan; Lee, Joon Woo; J, Lee; Lee, Chang‐Hoon; Kim, Duck-Su; Kwon, Il Keun

doi:10.1016/j.bbrc.2011.08.057

Cited by 50 publications

(37 citation statements)

References 25 publications

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“…Surface functionalization of Ti with heparin has several advantages. Because of their highly negative charge and high binding affinities for growth factors, heparin molecules can facilitate the immobilization of growth factors on the surface of Ti substrate through electrostatic interactions between the growth factors and heparin, and can minimize rapid diffusion and regulate the sustained release of growth factors or drugs from substrates to improve their efficacies [16,32,[37][38][39][40]. Indeed, we confirmed that LF was successfully immobilized on the surface of Hep-Ti substrates and that the amount of LF immobilized increased with increasing feed amounts of LF.…”

Section: Discussionmentioning

confidence: 99%

Osteoblast activity of MG-63 cells is enhanced by growth on a lactoferrin-immobilized titanium substrate

Kim

Yun

Lee

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Section: Discussionmentioning

confidence: 99%

Osteoblast activity of MG-63 cells is enhanced by growth on a lactoferrin-immobilized titanium substrate

Kim

Yun

Lee

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…Heparin is a highly sulfated glycosaminoglycan with anticoagulant and anti-inflammatory activity. Heparin has high binding affinities for growth factors and drugs and regulates their release [40][41][42][43][44]. However, no study has shown the effects of heparin on the sustained release of LF.…”

Section: Discussionmentioning

confidence: 99%

Effect of lactoferrin-impregnated porous poly(lactide-co-glycolide) (PLGA) microspheres on osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs)

Kim

Yun

Shim

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…Some researchers reported that alendronate enhanced the osteogenic differentiation of osteoblasts and bone marrow mesenchymal stem cells. 43,44) Moon et al 45) demonstrated that alendronate-immobilized titanium implant surface showed enhancement of osteoblast function as well as h and then decline gradually. McKenzie et al 48) also investigated the elution of zolendronic acid from a porous apatite-coated tantalum implant using a radio-labeling technique and claimed that the elution of zoledronic acids mainly localized in peri-implant bone, and peri-implant bone formation was strongly confined to the immediate space around the implant border.…”

Section: Discussionmentioning

confidence: 99%

Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets

Raita

Komatsu

Nifuji

et al. 2014

J. Hard Tissue Biology.

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The aim of this study was to evaluate the effects of alendronate immobilization on bone formation following the implantation of apatite-coated titanium implants in rats. Thin carbonate-containing apatite coatings were deposited onto titanium implants (Ti implants) using a molecular precursor method. Alendronate was then immobilized on apatite-coated titanium implants (HA implants) by immersing the HA implants in alendronate solution (Ald implants). The rat molars were extracted, and the implants were immediately placed in the tooth sockets. Bone labeling was performed 14 and 7 days before sacrifice. At 3 and 9 weeks after implantation, undecalcified sections were prepared and bone histomorphometry was performed. Greater bone mass was found around the Ald implants than around either the Ti or HA implants at both 3 weeks and 9 weeks. At 3 weeks, fluorochrome bone labeling was greater around the Ald implants than around the Ti implants, and the values of bone to implant contact (BIC) and bone mass (BM) were significantly greater around the Ald implants than around the HA and Ti implants. At 9 weeks, bone labeling decreased and the values of BIC and BM increased compared with those at 3 weeks for all types of implant. In conclusion, we found that immobilized alendronate triggered pronounced bone formation around the implants at an early stage of bone healing. These results suggest that alendronate immobilization accelerates implant fixation early in the healing phase.

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Effect of heparin and alendronate coating on titanium surfaces on inhibition of osteoclast and enhancement of osteoblast function

Cited by 50 publications

References 25 publications

Osteoblast activity of MG-63 cells is enhanced by growth on a lactoferrin-immobilized titanium substrate

Osteoblast activity of MG-63 cells is enhanced by growth on a lactoferrin-immobilized titanium substrate

Effect of lactoferrin-impregnated porous poly(lactide-co-glycolide) (PLGA) microspheres on osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs)

Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets

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