Effect of Hematocrit Concentration on Blood Glucose Value Determined on Glucometer II

Abstract

Nineteen patient blood samples each with modified hematocrit concentrations of approximately 20, 30, 40, 50, and 60%, were assayed for their glucose concentration by the Glucometer II. Blood removal from the test strip was by the one- and two-blot techniques. The reference method was the Yellow Springs Instruments (YSI) blood glucose analyzer. Glucometer II results were falsely high for the single blot (13-59%, mean 33%) and double blot (12-41%, mean 19%) at 20% hematocrit and falsely low at 60% hematocrit for the single blot (22-44%, mean 37%) and the double blot (26-49%, mean 43%). At 40-50% hematocrit, Glucometer II and YSI results agreed only for the one-blot technique.

Influence of Simulated Altitude on the Performance of Five Blood Glucose Meters

“…Deviations in blood glucose concentrations using BGMs at high altitudes could result from errors due to one or more of these factors (6). An increase in hematocrit, a factor known to alter the measurements of blood glucose with BGMs, may also occur in subjects chronically exposed to high altitude (12). In the present study, only partial oxygen pressure was progressively decreased to simulate altitude, ambient temperature, and relative humidity remaining constant, while hematocrit did not change over time.…”

Glucose Biosensors: An Overview of Use in Clinical Practice

“…Hematocrit values have a marked effect on the strip-based glucose assay [103,104]. Oxygen from red blood cells can compete with the redox mediator for glucose-derived electrons in strips when the enzyme used is GOx.…”

Performance of Seven Blood Glucose Testing Systems at High Altitude

“…4 In the present study, subjects' hematocrits varied from 3t%-44*%. The data reported here are corrected for hematocrit.…”