Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis

Fang, Yizhen; Fan, Chunhong; Xie, Huabin

doi:10.1097/md.0000000000018348

Cited by 31 publications

(27 citation statements)

References 43 publications

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“…It colonizes the gastric milieu of more than half of the global population and is associated with gastric diseases such as peptic ulcer, chronic gastritis, gastric cancer, and mucosa associated lymphoid tissue (MALT) lymphoma [2,3]. In addition, H. pylori has also been associated with some nongastrointestinal diseases such as pre-eclampsia, autoimmune thyroid diseases, acute coronary diseases, myocardial infarction, hepatic encephalopathy, prostatitis, and psoriasis [4][5][6][7]. H. pylori is responsible for iron deficiency anemia, thrombocytopenia, fetal malformation, and fetal growth retardation in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016

et al. 2021

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Most of the Helicobacter pylori infections occur in developing countries. The risk factors for H. pylori infections are poverty, overcrowding, and unhygienic conditions, which are common problems in under-privileged countries such as Nepal. Despite having a high risk of H. pylori infections, no national level study has been conducted to assess prevalence and correlates of H. pylori infection in Nepal. Therefore, we hypothesized that micronutrients such as iron, vitamin B12 deficiency, socio-economic status, and nutritional status correlate with the prevalence of H. pylori infection in Nepal. We studied prevalence and correlates of H. pylori infection among under-five children, adolescents aged 10–19 years and married women of reproductive age (aged 20–49 years) using data from the Nepal National Micronutrient Status Survey 2016 (NNMSS-2016). H. pylori infection was examined in stool specimens of 6–59 months old children, and 20–49 years old non-pregnant women by using a rapid diagnostic kit while blood samples was used to assess the H. pylori infection among adolescent boys and girls. Prevalence of H. pylori infection was 18.2% among 6–59 months old children, 14% among adolescent boys and 16% among adolescent girls aged 10–19 years; and 40% among 20–49 years non-pregnant women. Poor socioeconomic status, crowding, and unhygienic condition were found to be positively associated with higher incidence of H. pylori infections. No significant correlation was observed between nutritional and micronutrients status (iron or risk of folate deficiency) and H. pylori infection. Findings from this study suggest that poverty-associated markers are primary contributors of H. pylori infections in Nepalese communities. To control acquisition and persistence of H. pylori infection in Nepal, we suggest improved management of safe drinking water and implementation of sanitation and hygiene programs, with a focus on those of lower socioeconomic status.

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Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016

et al. 2021

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“…To date, numerous studies have shown the association between H. pylori infection and ASCVD. Recently, a meta-analysis involving 7522 cases and 8311 controls demonstrated that H. pylori infection increased the odds of an acute coronary syndrome (ACS) (odds ratio, OR = 2.03, 95% confidence interval, CI 1.66-2.47), especially in the developing countries, compared to the developed countries (OR = 2.58 vs. OR = 1.69, respectively) [62]. A suggested explanation for the discrepancy between the developing and developed countries is the access to primary prevention therapies against ASCVD (i.e., lipid-lowering drugs) which modifies the course of the disease [62].…”

Section: Helicobacter Pylorimentioning

confidence: 99%

Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic Implications

Szwed

Zawadka

Eyileten

et al. 2021

JCM

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Atherosclerotic cardiovascular diseases (ASCVD) are the major cause of mortality worldwide. Despite the continuous progress in ASCVD therapy, the residual risk persists beyond the management of traditional risk factors. Several infections including Helicobacter pylori infection, periodontal disease, and viral infections are associated with the increased risk of ASCVD, both directly by damage to the heart muscle and vasculature, and indirectly by triggering a systemic proinflammatory state. Hence, beyond the optimal management of the traditional ASCVD risk factors, infections should be considered as an important non-classical risk factor to enable early diagnosis and appropriate treatment. Here, we summarized the currently available evidence regarding the role of inflammation in ASCVD and the association between the particular infections and pathogens (Helicobacter pylori, periodontal disease, pneumonia, Cytomegalovirus, Human immunodeficiency virus, Herpes simplex virus, and severe acute respiratory syndrome coronavirus 2) on the development and progression of ASCVD. We also speculated about the potential therapeutic implications of the anti-inflammatory and anti-infective drugs on ASCVD outcomes, including drugs routinely administered in patients with ASCVD (statins, P2Y12 receptor inhibitors, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) and novel strategies aiming at residual risk reduction (colchicine, anti-cytokine drugs, and methotrexate). Considering the emerging association between infections and ASCVD, it is crucial to determine the possible advantages of infection prevention and treatment in patients with ASCVD.

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“…17 Fang et al, in a systematic review with meta-analysis, found that H pylori infection was associated with an increased risk of ACS (OR, 2.03; 95% CI, 1.66-2.47), higher for developing countries than for developed countries (OR 2.58 vs OR 1.69). 18 Choi et al, using an evaluation of cardio-ankle vascular index (CAVI), correlated arterial stiffness, a predictor of cardiovascular events, to anti-H pylori IgG antibody. Median age (P < .001), systolic blood pressure (P = .027), LDL-C levels (P = .016), median CAVI value and proportion of subjects with high CAVI value (both P < .001) were significantly higher in case of H pylori seropositivity.…”

Section: Ard I Ova Scul Ar and Cereb Rova Scul Ar D Is E A S E Smentioning

confidence: 99%

“…Fang et al, in a systematic review with meta‐analysis, found that H pylori infection was associated with an increased risk of ACS (OR, 2.03; 95% CI, 1.66‐2.47), higher for developing countries than for developed countries (OR 2.58 vs OR 1.69) 18 …”

Section: Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis

Cited by 31 publications

References 43 publications

Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016

Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016

Infections as Novel Risk Factors of Atherosclerotic Cardiovascular Diseases: Pathophysiological Links and Therapeutic Implications

Review: Extragastric diseases andHelicobacter pylori

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