Effect of Habits and Nutritional Status on Clinical Grading and Histopathological Staging in Patients with Oral Sub Mucous Fibrosis

Singh, Abhayjeet; Lanke, Rama Brahmam; Shetty, Rakhith; Akifuddin, Syed; Sahu, Manish; Singh, Navneet; Kaur, Gagandeep; Goyal, Garish

doi:10.7860/jcdr/2015/16013.6648

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…trismus, altered gustatory sensation, difficulty in swallowing, nasal voice and burning sensation affecting the oral, oropharyngeal and sometimes the esophageal mucosa. 3 Amongst these symptoms the most common presenting symptoms reported by patients is progressive inability to open mouth. Even after surgery it leaves the affected individual with inability to open mouth appropriately.…”

Section: Introductionmentioning

confidence: 99%

“…2 OSF is essentially a collagen metabolic disorder due to the imbalance in the formation and degradation of extracellular matrix that includes collagen as a constituent. Transforming growth factor-beta has significant role in the production and deposition of extracellular matrix 3 by acting as a potent stimulator and is expressed in OSF tissue samples along with connective tissue growth factor. 20,21 The normal integrity of the connective tissue is maintained by balanced collagen metabolism depicted by equilibrium by the two enzymes MMPs and TIMPs.…”

Section: Introductionmentioning

confidence: 99%

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Oral Submucous Fibrosis;

Shaikh

Ahmed

Siddique

et al. 2019

TPMJ

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Objectives: Oral Submucous Fibrosis is a chronic, high risk, debilitating, pre-cancerous oral condition that is prevalent in Southeast Asian consumers of areca nut. This study was conducted to determine regarding gender specificity with relation to stages of OSF and medical & surgical treatment modalities. Setting: OSF patients treated at Oral Surgery clinics of Dow International Medical College, Dow University of Health Sciences. Period: From January 2016 to November 2017. Design of Study: Cross-sectional Hospital based study. Materials & Methods: Patients were divided into four groups based on their clinical presentations according to Khanna JN and Andrade NN classification. Two groups were divided based on treatment modalities. First group comprised of patients treated conservatively with medications and physiotherapy while the second group comprised of patients treated surgically. Results: Out of 225 patients treated with OSF, 88% of them were males while 12% were females with male to female ratio of 7:1. As per Khanna & Andrade classification, 9.7% belonged to group II, while 34.6% belonged to III and 55.5% of OSF patients belonged to IV-A. 56.8% of patients were treated conservatively while 43.1% were treated surgically. In the group of patients treated surgically, majority 84.6% of patients were treated with buccal fat pad while only 15.4% has nasolabial flap surgery performed. Conclusion: Statistical significant difference male preponderance in OSF disease severity was observed as compared to women in this sample of Pakistani population reporting to tertiary care hospital. A holistic approach should be undertaken with public health policies in place to discourage the use of areca nut products with or without tobacco and lower the burden of OSF in the general population.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral Submucous Fibrosis;

Shaikh

Ahmed

Siddique

et al. 2019

TPMJ

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“…6 The duration and frequency of betel nut products used, affects the incidence and severity of oral submucous fibrosis. [7] Iron content can be a predictor for the progression of Oral submucous fibrosis. This condition had been previously described as "sideropenic Section: Dentistry dysphagia."…”

Section: Introductionmentioning

confidence: 99%

Estimation of Iron and Vitamin C Levels In Serum and Saliva: A Clinical and Biochemical Study In Oral Submucous Fibrosis Patients

Bhalerao¹,

Lohe²,

Bhowate³

2018

AIMDR

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Background: OSMF is a well-recognized, potentially malignant condition of the oral cavity. Monitoring the widespread consequences of OSMF requires interventions in at-risk persons ideally earlier the disease becomes aggressive. Iron and vitamin C have been widely studied in recent years to judge whether they have any modifying effects in the etiology of precancer and cancer. Aim of study was to evaluate levels of iron and vitamin C in serum and saliva in patients with OSMF. Methods: Study group comprised of 66 patients, out of which 22 cases of clinically diagnosed OSMF patients and 22 cases of betelnut habitual without OSMF and 22 cases of age and sex matched control healthy patients were recruited. Estimation of Iron by Ferrozine method and vitamin C by 2-4 dinitrophenylhydrazine method in serum and saliva was carried out by using Spectrophotometer. The statistical analysis was done. Results: Level of iron and vitamin C in serum and saliva was significantly decreased in OSMF patients when compared to betelnut habitual and controls group which were statistically significant. Conclusion: The present study, all the cases of OSMF showed decrease in iron and vitamin C levels which suggests that the iron and vitamin C plays an important role in the pathogenesis and progression of OSMF. In group II (Betel nut habituals without OSMF) patients showed decrease in iron and vitamin C levels which suggest that, betel nut quid with or without tobacco consumption may alter the serum and salivary levels of iron and vitamin C and plays an important role in the advancement of OSMF. Therefore regular monitoring of betel nut habituals should also be carried out because they are at higher risk of developing OSMF in future. Study indicates that saliva also may be used as a potential non-invasive diagnostic tool to evaluate the iron and vitamin C in OSMF patients. Estimation of iron and vitamin C in OSMF patients would help in management, in developing therapies based on the trace element expression.

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Lifestyle Factors

Yang

Warnakulasuriya

2023

Oral Submucous Fibrosis

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Effect of Habits and Nutritional Status on Clinical Grading and Histopathological Staging in Patients with Oral Sub Mucous Fibrosis

Cited by 3 publications

References 10 publications

Oral Submucous Fibrosis;

Oral Submucous Fibrosis;

Estimation of Iron and Vitamin C Levels In Serum and Saliva: A Clinical and Biochemical Study In Oral Submucous Fibrosis Patients

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