Effect of Green Coffee Bean Extract Supplementation on Body Fat Reduction in Mildly Obese Women

Abstract

In previous studies, we performed joint animal studies and clinical trials between Yonsei University and Oryza Oil & Fat Chemical Co. Ltd. We have shown that coffee bean extract has potent anti-obesity and hypotriglyceridemic activities as well as beneficial effects on body fat reduction.In this study, the effects of coffee bean extract (100 mg/capsule) on body fat reduction were evaluated in overweight/obese women (body mass index of 25~30 kg/m 2 or body fat > 30%) not diagnosed with any type of disease. Subjects were randomly assigned to a coffee bean extract group (n=10) or placebo group (n=10). We measured anthropometric parameters, abdominal fat distribution by computed tomography and blood components before and after the 8week intervention period. After supplementation, the coffee bean extract group showed body weight (p=0.08), body mass index (p=0.06), hip circumference (p<0.05), and upper waist circumference (p< 0.01).In addition, after 8 weeks, the coffee bean extract group showed a significant decrease in abdominal internal fat area compared to 0 weeks (0 weeks : 155.8 cm 2 ; 8 weeks : 145.9 cm 2 , ∆ change : −9.9 cm 2 , respectively). However, there were no significant differences in lipid profiles or serological measurements between the coffee bean extract group and placebo group. The results of our human study demonstrated that coffee bean extract supplementation for 8 weeks has beneficial effects on reducing abdominal internal fat area as well as hip and waist circumferences.

The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

“…The characteristics of the included studies are detailed in Table 1. These studies were published between 2005 and 2019 (February) and were conducted in Iran [17,20,29,19], South Korea [32,33], Spain [28], Colombia [31], and Japan [27,30,34,35,36]. The follow-up period ranged from 2 to 12 weeks.…”

“…The follow-up period ranged from 2 to 12 weeks. The daily supplementation dose of green coffee varied between 46 and 6000 mg. Apart from studies which included both sexes, four trials were conducted in women only [19,30,32,33] and six studies were performed in men only [17,27,36]. The sample size of the RCTs ranged from 16 [27] to 70 [17,27].…”

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Ultimately, 10 publications were included in this study. Of the 10 eligible articles, all 10 trials reported the influences of GCE on FBS (Fukagawa et al, 2017;Haidari, Samadi, Mohammadshahi, Jalali, & Engali, 2017;Kim et al, 2012;Ochiai et al, 2004;Park, Kim, Lee, & Lee, 2010;Roshan et al, 2018;Shahmohammadi, Hosseini, Hajiani, Malehi, & Alipour, 2017;Soga et al, 2013;Suzuki et al, 2019;Watanabe et al, 2006), and five trials reported on insulin (Fukagawa et al, 2017;Haidari et al, 2017;Park et al, 2010;Roshan et al, 2018;Shahmohammadi et al, 2017) (Figure 1).…”

“…The characteristics of the eligible trials are detailed in Table 1. Included papers were published between 2004 and 2019 and were conducted in different countries, including three in Iran (Haidari et al, 2017;Roshan et al, 2018;Shahmohammadi et al, 2017), five in Japan (Fukagawa et al, 2017;Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019;Watanabe et al, 2006), and two in Korea (Kim et al, 2012;Park et al, 2010). The treatment duration varied between 2 and 16 weeks, while daily administrated dosage of GCE ranged from 100 to 1,000 mg. Studies were conducted on both genders (Roshan et al, 2018;Shahmohammadi et al, 2017;Watanabe et al, 2006), on men (Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019) and on women-only (Fukagawa et al, 2017;Haidari et al, 2017;Kim et al, 2012;Park et al, 2010).…”

“…Included papers were published between 2004 and 2019 and were conducted in different countries, including three in Iran (Haidari et al, 2017;Roshan et al, 2018;Shahmohammadi et al, 2017), five in Japan (Fukagawa et al, 2017;Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019;Watanabe et al, 2006), and two in Korea (Kim et al, 2012;Park et al, 2010). The treatment duration varied between 2 and 16 weeks, while daily administrated dosage of GCE ranged from 100 to 1,000 mg. Studies were conducted on both genders (Roshan et al, 2018;Shahmohammadi et al, 2017;Watanabe et al, 2006), on men (Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019) and on women-only (Fukagawa et al, 2017;Haidari et al, 2017;Kim et al, 2012;Park et al, 2010). The participant number in the studies ranged from 16 to 64, while the study population in eligible publications consisted of adults with mild hypertension (Watanabe et al, 2006), adults with the metabolic syndrome (Roshan et al, 2018), adults with NAFLD (Nonalcoholic Fatty Liver Disease) (Shahmohammadi et al, 2017), and adults who were classified as obese or overweight (Haidari et al, 2017;Kim et al, 2012;Park et al, 2010), or healthy individuals (Fukagawa et al, 2017;Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019).…”