The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Ding, Feng; Ma, Bin; Nazary-Vannani, Ali; Kord‐Varkaneh, Hamed; Fatahi, Somaye; Papageorgiou, Maria; Rahmani, Jamal; Poursoleiman, Faezeh; Nascimento, Israel Júnior Borges do; Li, Hui; Han, Dongyang; Wang, Dongmei

doi:10.1016/j.numecd.2019.10.002

Cited by 26 publications

(10 citation statements)

References 40 publications

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“…In our meta-analysis, the beneficial effects of GCE supplementation were mostly observed in RCTs with a long duration of the intervention (≥8 weeks). It is consistent with the results from the previous meta-analysis on green coffee consumption in which a longer duration (> 8 weeks) was more effective on lipid profile [ 56 ]. In a network meta-analysis, Kondo et al concluded that clinical trials with a longer duration of intervention can better clarify the potential effects of coffee [ 47 ].…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 74%

“…However, the TG-lowering effect of CGA was decreased at a dosage of 500 mg/d and over. The effect of green coffee on lipid profile was also dose-dependent in earlier meta-analyses of RCTs [ 56 , 57 ]. Therefore, the dosage of CGA is a potential moderator for the beneficial effect of GCE on lipid profile.…”

Section: Discussionmentioning

confidence: 82%

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The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials

Asbaghi

Sadeghian

Nasiri

et al. 2020

Nutr J

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Background: The role of coffee consumption in the risk of cardiovascular diseases has been debated for many years. The current study aimed to summarize earlier evidence on the effects of green coffee extract (GCE) supplementation on glycemic indices and lipid profile. Methods: We searched available online databases for relevant clinical trials published up to October 2019. All clinical trials investigating the effect of GCE supplementation, compared with a control group, on fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were included. Overall, 14 clinical trials with a total sample size of 766 participants were included in the current meta-analysis. Results: We found a significant reducing effect of GCE supplementation on FBG (weighted mean difference (WMD):-2.35, 95% CI: − 3.78, − 0.92 mg/dL, P = 0.001) and serum insulin (WMD:-0.63, 95% CI: − 1.11, − 0.15 μU/L, P = 0.01). With regard to lipid profile, we observed a significant reduction only in serum levels of TC following GCE supplementation in the overall meta-analysis (WMD:-4.51, 95% CI: − 8.39, − 0.64, P = 0.02). However, subgroup analysis showed a significant reduction in serum TG in studies enrolled both genders. Also, such a significant reduction was seen in serum levels of LDL and HDL when the analyses confined to studies with intervention duration of ≥8 weeks and those included female subjects. In the non-linear dose-response analyses, we found that the effects of chlorogenic acid (CGA) dosage, the main polyphenol in GCE, on FBG, TG and HDL were in the nonlinear fashions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 74%

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The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials

Asbaghi

Sadeghian

Nasiri

et al. 2020

Nutr J

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“…Dyslipidemia, particularly increased levels of serum total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) and low levels of high‐density lipoprotein cholesterol (HDL‐C), is considered a strong risk factor for CVD. There is strong evidence for the decrease in CVD incidence due to a reduction in TC and LDL‐C levels (Ali et al, 2012) and an increase in HDL‐C levels (Genser et al, 2012; Nelson, 2013), which can be achieved by dietary approaches or lipid‐lowering agents (Ding et al, 2020; Ghaedi et al, 2019; Kord Varkaneh et al, 2022; Meng et al, 2020; Mousavi et al, 2019; Rahmani et al, 2019; Shi et al, 2021; Taylor et al, 2013; Xia et al, 2020). Phytosterol is a collective term used for plant sterols and stanols.…”

Section: Introductionmentioning

confidence: 99%

The effect of phytosterol supplementation on lipid profile: A critical umbrella review of interventional meta‐analyses

Wang,

Feng,

Prabahar

et al. 2023

Phytotherapy Research

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Despite multiple investigations assessing the impact of phytosterol supplementation on serum lipid levels, there is still a great deal of debate regarding the benefits of this intervention in the management of dyslipidemia. Therefore, we aimed at clarifying this dilemma by conducting the present umbrella review of interventional meta‐analyses. Scopus, PubMed, Web of Science, and EMBASE were used to search for pertinent publications on the effect of phytosterol supplementation on the lipid profile in humans up to June 2023. To compute the overall effect size (ES) and confidence intervals (CI), the random‐effects model was used. The I2 statistic and Cochrane's Q‐test were applied to estimate the heterogeneity among the studies. Seventeen meta‐analyses with 23 study arms were included in the umbrella meta‐analysis. Data pooled from the 23 eligible arms revealed that phytosterol supplementation reduces low‐density lipoprotein cholesterol (LDL‐C) (ES = −11.47 mg/dL; 95% CI: −12.76, −10.17, p < 0.001), total cholesterol (TC) (ES = −13.02 mg/dL; 95% CI: −15.68, −10.37, p < 0.001), and triglyceride (TG) (ES = −3.77 mg/dL; 95% CI: −6.04, −1.51, p = 0.001). Subgroup analyses showed that phytosterol administration with dosage ≥2 g/day and duration over 8 weeks and in hypercholesterolemic subjects was more likely to decrease LDL‐C, TC, and TG. Phytosterol administration did not significantly modify HDL‐C (ES = 0.18 mg/dL; 95% CI: −0.13, −0.51, p = 258) levels when compared to controls. The present umbrella meta‐analysis confirms that phytosterol administration significantly reduces LDL‐C, TC, and TG, with a greater effect with doses of ≥2 g/day and treatment duration >8 weeks, suggesting its possible application as a complementary therapy for cardiovascular risk reduction. Further studies are needed to determine the efficacy of phytosterols in patients with specific health conditions, as well as to ascertain the adverse effects, the maximum tolerable dose, and the maximum recommended duration of phytosterol administration.

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“…Accumulating evidence has examined the effects of green tea products on traditional and novel cardiovascular risk factors such as hypertension, lipid disorders, diabetes, oxidative stress, endothelial dysfunction, and inflammation ( 11 ). Among lifestyle modification strategies for controlling CVD risk factors, regular consumption of functional foods rich in antioxidants and polyphenols such as coffee ( 12 ), dark chocolate ( 13 ), nuts ( 14 ) and green tea ( 12 ) have been proposed to promote cardiometabolic risk factors.…”

Section: Introductionmentioning

confidence: 99%

The effects of green tea supplementation on cardiovascular risk factors: A systematic review and meta-analysis

et al. 2023

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PurposeA bulk of observational studies have revealed the protective role of green tea supplementation in cardiovascular diseases. The current systematic review and meta-analysis study aimed to establish the effects of green tea supplementation on cardiovascular risk factors including lipid profile, blood pressure, glycemic control markers and CRP.MethodsA systematic literature search of randomized clinical trials (RCTs) that investigated the effects of green tea supplementation and cardiovascular risk factors was undertaken in online databases including PubMed/Medline, Scopus, Web of Science, and Embase using a combination of green tea and cardiovascular risk factors search terms. Meta-analyses were carried out using a random-effects model. The I2 index was used to assess the heterogeneity of RCTs.ResultsAmong the initial 11,286 studies that were identified from electronic databases search, 55 eligible RCTs with 63 effect sizes were eligible. Results from the random effects meta-analysis showed that GTE supplementation significantly reduced TC (WMD = −7.62; 95% CI: −10.51, −4.73; P = < 0.001), LDL-C (WMD = −5.80; 95% CI: −8.30, −3.30; P = < 0.001), FBS (WMD = −1.67; 95% CI: −2.58, −0.75; P = < 0.001), HbA1c (WMD = −0.15; 95% CI: −0.26, −0.04; P = 0.008), DBP (WMD = −0.87; 95% CI: −1.45, −0.29; P = 0.003), while increasing HDL-C (WMD = 1.85; 95% CI: 0.87, 2.84; P = 0.010). Subgroup analyses based on the duration of supplementation (≥ 12 vs. < 12 weeks), dose of green tea extract (GTE) (≥1,000 vs. < 1,000 mg/d), sex (male, female, and both), baseline serum levels of lipid profile, and glycemic control factors demonstrated different results for some risk factors.ConclusionThe current study suggests improvements in the lipid and glycemic profiles following green tea supplementation. These findings support previous evidence showing the health benefits of green tea supplementation on cardiometabolic risk factors.

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The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Cited by 26 publications

References 40 publications

The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials

The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials

The effect of phytosterol supplementation on lipid profile: A critical umbrella review of interventional meta‐analyses

The effects of green tea supplementation on cardiovascular risk factors: A systematic review and meta-analysis

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