Effect of Garcinia cambogia extract on serum leptin and insulin in mice

Hayamizu, Kohsuke; Hirakawa, Hironori; Oikawa, Daichi; Nakanishi, Tomonori; Takagi, Tsutomu; Tachibana, Tetsuya; Furuse, Mitsuhiro

doi:10.1016/s0367-326x(03)00036-4

Cited by 56 publications

(44 citation statements)

References 22 publications

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“…In animal models, however, administration of standardized G. cambogia extract (60% hydroxycitrate) over a 4 week period has been shown to prompt a decrease in levels of serum fatty acid, total cholesterol, insulin and leptin (Hayamizu et al, 2003), a hormone secreted by adipose tissue and closely involved in regulating energy balance (Havel, 2001).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity

Vasques

Rossetto

Halmenschlager

et al. 2008

Phytotherapy Research

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Hydroxycitric acid (HCA), the main compound of Garcinia cambogia extract, is a competitive blocker of ATP-citrate-lyase, presenting a potential inhibition of fatty acid biosynthesis. Glucomannan fibers, abundant in Amorphophallus konjac, seem to reduce the absorption kinetics of dietary fat. Therefore, the aim of this double-blind randomized study was to evaluate the pharmacotherapeutic efficacy of standardized extracts of G. cambogia (52.4% HCA) plus A. konjac (94.9% glucomannan) in the treatment of obesity. Fifty-eight obese subjects (BMI 30.0-39.9 kg/m(2)) were assigned to the placebo group (n = 26) or the treatment group (n = 32); no dietary restrictions were applied. Over a 12-week period, subjects were given daily doses of either Garcinia (2.4 g) plus Konjac (1.5 g) or placebo prior to their main meals (3 times/day). Before the start of treatment, and every 4 weeks thereafter, the following were recorded: height, weight, circumferences and body composition, resting energy expenditure (REE), lipid profile and glucose levels. The treatment had no significant effect on anthropometric parameters, REE, triglycerides or glucose levels. However, a significant reduction was observed in total cholesterol (-32.0 +/- 35.1 mg/dL) and LDL-c levels (-28.7 +/- 32.7 mg/dL) in the treated group, the final levels being significantly lower than those of the placebo group (p = 0.008 and p = 0.020, respectively). The results obtained suggest that the treatment had a significant hypocholesterolemic effect, without influencing the anthropometric or calorimetric parameters tested.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity

Vasques

Rossetto

Halmenschlager

et al. 2008

Phytotherapy Research

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“…Thus, (-)-HCA supplementation is expected to alter metabolic pathways. Although some studies have shown (-)-HCA possesses anti-obesity activity [36, 37] and anti-diabetic activity [38, 39], little information is available on whether (-)-HCA affects fat accumulation in broiler chickens through regulation on the energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Li¹,

Peng²,

Ge³

et al. 2017

Cell Physiol Biochem

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Background/Aims: (-)-Hydroxycitric acid (HCA) had been shown to suppress fat accumulation in animals and humans, while the underlying biochemical mechanism is not fully understood, especially little information is available on whether (-)-HCA regulates energy metabolism and consequently affects fat deposition. Methods: Hepatocytes were cultured for 24 h and then exposed to (-)-HCA (0, 1, 10, 50 µM), enzyme protein content was determined by ELISA; lipid metabolism gene mRNA levels were detected by RT-PCR. Results: (-)-HCA significantly decreased the number and total area of lipid droplets. ATP-citrate lyase, fatty acid synthase and sterol regulatory element binding protein-1c mRNA level were significantly decreased after (-)-HCA treatment, whereas peroxisome proliferator-activated receptor α mRNA level was significantly increased. (-)-HCA significantly decreased ATP-citrate lyase activity and acetyl-CoA content in cytosol, but significantly increased glucose consumption and mitochondrial oxygen consumption rate. (-)-HCA promoted the activity/content of glucokinase, phosphofructokinase-1, pyruvate kinase, pyruvate dehydrogenase, citrate synthase, aconitase, succinate dehydrogenase, malate dehydrogenase, NADH dehydrogenase and ATP synthase remarkably. Conclusions: (-)-HCA decreased lipid droplets accumulation by reducing acetyl-CoA supply, which mainly achieved via inhibition of ATP-citrate lyase, and accelerating energy metabolism in chicken hepatocytes. These results proposed a biochemical mechanism of fat reduction by (-)-HCA in broiler chickens in term of energy metabolism.

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“…2). However, Hayamizu et al (30) have reported that blood lipids and the insulin/glu cose ratio were lowered by G. cambogia extract ingestion and serum leptin concentration was slightly decreased, without significance.…”

Section: Hca and Lipogenesismentioning

confidence: 97%

“…Similarly, after restriction feeding periods, HCA ingestion reduced body weight regain in rats for at least 22d of ad libitum feed ing with diets containing 1 and 12% fat (36). Even when mice were provided with water containing 10% of sucrose for 4wk energy gain from food and sucrose tended to be reduced by HCA ingestion, without body weight gain (Table 1) (30). As shown in Table 1, the adipose tissue-decreasing effect of Garcirnia cambogia fruit rind extract was not detected for 3.3% of HCA-added diet, instead of cellu lose, for 4wk.…”

Section: Hca and Lipogenesismentioning

confidence: 99%