Evaluation of the pharmacotherapeutic efficacy of <i>Garcinia cambogia</i> plus <i>Amorphophallus konjac</i> for the treatment of obesity

Vasques, Carlos A. R.; Rossetto, Simone; Halmenschlager, Graziele; Linden, Rafael; Heckler, Eliane; Fernández, María Sanz; Alonso, José Luís Lancho

doi:10.1002/ptr.2323

Cited by 74 publications

(50 citation statements)

References 20 publications

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“…Thus, (-)-HCA supplementation is expected to alter metabolic pathways. Although some studies have shown (-)-HCA possesses anti-obesity activity [36, 37] and anti-diabetic activity [38, 39], little information is available on whether (-)-HCA affects fat accumulation in broiler chickens through regulation on the energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Li¹,

Peng²,

Ge³

et al. 2017

Cell Physiol Biochem

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Background/Aims: (-)-Hydroxycitric acid (HCA) had been shown to suppress fat accumulation in animals and humans, while the underlying biochemical mechanism is not fully understood, especially little information is available on whether (-)-HCA regulates energy metabolism and consequently affects fat deposition. Methods: Hepatocytes were cultured for 24 h and then exposed to (-)-HCA (0, 1, 10, 50 µM), enzyme protein content was determined by ELISA; lipid metabolism gene mRNA levels were detected by RT-PCR. Results: (-)-HCA significantly decreased the number and total area of lipid droplets. ATP-citrate lyase, fatty acid synthase and sterol regulatory element binding protein-1c mRNA level were significantly decreased after (-)-HCA treatment, whereas peroxisome proliferator-activated receptor α mRNA level was significantly increased. (-)-HCA significantly decreased ATP-citrate lyase activity and acetyl-CoA content in cytosol, but significantly increased glucose consumption and mitochondrial oxygen consumption rate. (-)-HCA promoted the activity/content of glucokinase, phosphofructokinase-1, pyruvate kinase, pyruvate dehydrogenase, citrate synthase, aconitase, succinate dehydrogenase, malate dehydrogenase, NADH dehydrogenase and ATP synthase remarkably. Conclusions: (-)-HCA decreased lipid droplets accumulation by reducing acetyl-CoA supply, which mainly achieved via inhibition of ATP-citrate lyase, and accelerating energy metabolism in chicken hepatocytes. These results proposed a biochemical mechanism of fat reduction by (-)-HCA in broiler chickens in term of energy metabolism.

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Section: Introductionmentioning

confidence: 99%

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Li¹,

Peng²,

Ge³

et al. 2017

Cell Physiol Biochem

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“…An active ingredient extracted from the Garcinia cambogia, reduces caloric intake and cholesterol [38] and it is currently used in weight control [39].…”

Section: Hydroxycitratementioning

confidence: 99%

Calorie Restriction Mimetics: Examples and Mode of Action

Kyriazis¹

2009

TOLSJ

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Abstract:The search for Calorie Restriction Mimetics (CRM) -compounds that mimic the genetic, biochemical and physical actions of calorie restriction -is not a search for a 'lazy dieters pill'. It is a quest aiming to clarify the basic mechanisms of calorie restriction and develop strategies in order to prevent, treat or alleviate age-related conditions. The development of CRM will add new and important assets in our armamentarium of anti-ageing therapies, with the ultimate result of increasing healthy human lifespan. This Special Supplement on CRM is an attempt to discuss some agents which may be used instead of calorie restriction itself. Agents such as resveratrol, metformin, carnosine and Rimonabant are mainstream oral therapies already used by millions of people for other clinical indications. New CRM such as NADH, gugulipids and certain drugs that interfere with glucose metabolism can be also used as oral therapy. Less easily available CRM such as oxaloacetic acid, naloxone, leptin, adiponectin, rapamycin and sirtuins are further examples of promising agents. In order for the therapy to be effective, a combination of these must be used. This paper summarises the actions of calorie restriction and then suggests several examples of possible CRM. Some of these examples can be used in everyday clinical setting.

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“…Amorphophallus konjac (konjac) has long been planted in Southeast Asia and East Asia as food source and traditional medicine [1]. Previous study has reported that konjac soft rot caused by the genus Pectobacterium is one major reason of limited konjac products [2].…”

Section: Introductionmentioning

confidence: 99%

Genetic Relationships of Soft Rot Bacteria Isolated from Konjac in China by Amplified Fragment Length Polymorphism (AFLP) and 16S rDNA Gene Sequences

Wu¹,

Yang²,

Jiao³

et al. 2015

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Twenty-three isolates of soft rot bacteria from konjac corms were examined for their diversity using 16S rDNAs and AFLP technology. Both methods clustered two groups, dependent on their biotype characterization of Pectobacterium carotovora subsp. carotovora (P.c.c) and Pectobacterium chrysanthemi (P.ch), respectively. Of all isolates, 17 (73.9%) belonged to P. ch, indicated as the main pathogenic bacteria of konjac producing areas in China. The genetic variation among isolates from the same biotype was also rich, not consistent with the distances of the geographic sources.

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Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity

Cited by 74 publications

References 20 publications

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Calorie Restriction Mimetics: Examples and Mode of Action

Genetic Relationships of Soft Rot Bacteria Isolated from Konjac in China by Amplified Fragment Length Polymorphism (AFLP) and 16S rDNA Gene Sequences

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