Effect of gambogenic acid in attenuating diethylnitrosamine (DEN)-induced hepatocellular carcinoma in rat model

Zhang, Ruikui; Wu, Tao; Yang, Juan; Liu, Ming; Luo, Jing; Ma, Chi; Ma, Xiaoying; Xu, Guanghua; Zheng, Shusen

doi:10.1016/j.arabjc.2023.104644

Cited by 3 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The elevated serum levels of AST, ALT, and in particular the elevated ratio of AST/ALT observed in this study in HCAR-induced rats is an indication of liver destruction, which led to the elevated levels of the two transaminases in the serum. This finding is corroborated by the published results of Yakubu et al [14] and Zhang et al [15] , which reported elevated levels of AST and ALT in rat model of NDEA-induced HCAR. FEAC interventions ameliorated the NDEA-CCl 4 -induced HCAR by lowering the levels of the 2 transaminases and their ratio (AST:ALT ratio), which can be attributed to its hepatoprotective, antioxidative, and anticancer prowess as previously documented by Adeyi et al [16] and Zhai et al [27] .…”

Section: Discussionsupporting

confidence: 88%

“…Control rats were placed in group I and were intraperitoneally administered normal saline (the vehicle for NDEA) and sunflower oil (the vehicle for CCl 4 ). HCAR-induced rats were placed in group II and were intraperitoneally injected with 200 mg/kg of NDEA and 0.5 mL/kg of CCl 4 (a tumor promoter) simultaneously once a week for 3 weeks [14] , [15] . Rats placed in groups III and IV were treated equally like rats in group II but were orally treated with 25 and 50 mg/kg of FEAC [16] for another 3 weeks.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Somade,

Ajayi,

Adeyi

et al. 2024

Toxicology Reports

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Somade,

Ajayi,

Adeyi

et al. 2024

Toxicology Reports

View full text Add to dashboard Cite

“…Сравнительная функциональная геномика показала, что паттерны экспрессии генов в ГЦК при индуцированном диэтилнитрозамином раке печени мышей были наиболее сходны с ГЦК человека [10]. Подобно тому, что происходит у пациентов с ГЦК, эта модель характеризуется медленной многоступенчатой последовательностью, где циклы некроза и регенерации способствуют неопластической трансформации [11].…”

Section: химически индуцированные модели гцкunclassified

“…Кроме того, исследователей беспокоит временная и пространственная неоднородность возникновения опухолевых узлов. Данные недостатки сильно ограничивают использование данной методики [11].…”

Section: химически индуцированные модели гцкunclassified

Models of Liver Cancer in Vivo

Gurova¹,

Kecheryukova²,

Goncharova³

et al. 2023

СПНО (MPSE)

View full text Add to dashboard Cite

Гепатоцеллюлярная карцинома (ГЦК) является распространенной формой первичного рака печени и имеет высокий уровень смертности из-за ограниченных возможностей лечения. Этиология этого онкологического заболевания связана с инфекциями, вызванными вирусом гепатита С или В, употреблением алкоголя, курением, ожирением, неалкогольной жировой болезнью печени, диабетом. В развитии ГЦК участвуют многочисленные клеточные механизмы, которые включают в себя нарушение регуляции клеточного цикла и апоптоза, молекулярные пути, связанные с воспалением, процессы фиброгенеза. Все они, в свою очередь, представляют собой важные молекулярные мишени для разработки новых лекарственных препаратов. Животные модели сыграли одну из ключевых ролей в биомедицинских исследованиях и являются необходимыми инструментами для изучения и понимания патогенеза опухолевых заболеваний. Создание моделей ГЦК на животных необходимо как для фундаментальных, так и для трансляционных исследований. Лабораторная мышь представляет собой одну из лучших экспериментальных систем за счет физиологического, молекулярного и генетического сходства с человеком. Химически индуцированные модели, ксенографты, аллографты, генетически модифицированные мыши (GEM) являются ценными инструментами для выявления потенциальных биомаркеров заболевания, поиска мишеней, оценки новых терапевтических препаратов в доклинических испытаниях и разработки новых методов лечения. В данном обзоре мы рассмотрим наиболее используемые экспериментальные модели для изучения ГЦК. Ключевые слова: рак печени, гепатоцеллюлярная карцинома, ксенографт, аллографт, модели генетически модифицированных мышей, диэтилнитрозамин индуцированный гепатокарциногенез.

show abstract

“…High amounts of DEN given orally or intravenously to rats over a long period are very successful at causing hepatic tumours (Schma¨hl et al, 1960). DEN a hepatocarcinogen is used to induce hepatic carcinoma in experimental rats by a single intraperitoneal injection of 200mg/kg body weight (Zhang et al, 2023) Herbal-based medicine is the oldest form of health care known to humans. Due to their anti-tumour properties, plant-based products have recently attracted a lot of interest in the scientific community (Murthy et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Effect of Selected Fruit Wastes on Hematological Parameters in DEN-Induced Hepatic Carcinoma in Rats

Vijayalakshmi K,

Suganthi M

et al. 2023

J. Adv. Zool.

View full text Add to dashboard Cite

Fruits and processed food demand has greatly increased due to which a huge amount of fruit waste is generated. In this study, the effect of the ethanolic extract of waste material Punica granatum (pomegranate) peel and Vitis vinifera (grapes) seeds was evaluated on hematological parameters in Wistar rats with diethylnitrosamine (DEN) induced hepatocellular carcinoma. The treatments were divided into four groups: Group 1 was untreated while Groups 2-4 received 200 mg/kg body weight of DEN by single intraperitoneal administration. Groups 3 and 4 received DEN and co-treated with 400 mg/kg pomegranate peel extract and 400 mg/kg grape seed extract, respectively. There was a significant decrease in the body weight of animals in Group 2, while Group 3 and 4 animals were found to have a significant rise in body weight. The weight of the liver was significantly increased in the cancer-bearing group and its size was significantly reverted in the treated groups. The kidney and spleen showed a significant decrease in size of cancer-induced groups, and these organs significantly increased in treated groups. Hemoglobin, red blood cells (RBC), neutrophil, packed cell volume (PCV), Mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) were significantly reduced in Group 2 animals compared to Group 1. The levels of white blood cells (WBC) and erythrocyte sedimentation rate were increased significantly in Group 2 animals relating to Group 1. Both in Group 3 and 4 animals, these changes were reversed. Results reveal that selected fruit wastes alleviate vital hematological parameters in hepatocellular carcinoma-induced rats.

show abstract

Effect of gambogenic acid in attenuating diethylnitrosamine (DEN)-induced hepatocellular carcinoma in rat model

Cited by 3 publications

References 23 publications

Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Models of Liver Cancer in Vivo

Effect of Selected Fruit Wastes on Hematological Parameters in DEN-Induced Hepatic Carcinoma in Rats

Contact Info

Product

Resources

About