Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Somade, Oluwatobi T.; Ajayi, Babajide O.; Adeyi, Olubisi E.; Dada, Temitope A.; Ayofe, Mukodaz A.; Inalu, David C.; Ajiboye, Opeyemi I.; Shonoiki, Olaoluwawunmi M.; Adelabu, Aminat O.; Onikola, Rasaq T.; Isiaka, Ismaila D.; Omotoso, Opeyemi; James, Adewale S.; Olaniyan, Tunde O.; Adegoke, Ayodeji M.; Akamo, Adio J.; Oyinloye, Babatunji E.; Adewole, Ezekiel

doi:10.1016/j.toxrep.2024.01.006

Toxicology Reports

2024

DOI: 10.1016/j.toxrep.2024.01.006

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Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Oluwatobi T. Somade,

Babajide O. Ajayi,

Olubisi E. Adeyi

et al.

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2024

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Cited by 3 publications

References 51 publications

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Syringic acid through reduction of inflammation, oxidative injury, and downregulation of NF-κB-IL-6 pathway ameliorates HFD-induced pulmonary toxicity in male Wistar rats

Adeyi,

Somade,

Ugwor

et al. 2024

Comp Clin Pathol

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Syringic acid through reduction of inflammation, oxidative injury, and downregulation of NF-κB-IL-6 pathway ameliorates HFD-induced pulmonary toxicity in male Wistar rats

Adeyi,

Somade,

Ugwor

et al. 2024

Comp Clin Pathol

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Ferulic acid inhibits tumor proliferation and attenuates inflammation of hepatic tissues in experimentally induced HCC in rats

Abdulal,

Altahhan,

Qindil

et al. 2024

Journal of Investigative Medicine

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Hepatocellular carcinoma (HCC) is a prevalent form of primary liver cancer with a five-year survival rate of just 18%. Ferulic acid, a natural compound found in fruits and vegetables such as sweet corn, rice bran, and dong quai, is an encouraging drug known for its diverse positive effects on the body, including anti-inflammatory, anti-apoptotic, and neuroprotective properties. Our study aimed to investigate the potential anti-tumor effects of ferulic acid to inhibit tumor growth and inflammation of HCC in rats. HCC was induced in rats by administering thioacetamide. Additionally, some rats were given 50mg/kg of ferulic acid three times a week for 16 weeks. Liver function was assessed by measuring serum α-fetoprotein (AFP) and examining hepatic tissue sections stained with hematoxylin/eosin or anti-HIF-1α. The hepatic mRNA and protein levels of HIF-1α, NFκB, TNF-α, mTOR, STAT3, cMyc, and cyclin D1 were examined. The results showed that ferulic acid increased the rats' survival rate by reducing serum AFP levels and suppressing hepatic nodules. Furthermore, ferulic acid ameliorated the appearance of vacuolated cytoplasm induced by HCC, reduced apoptotic nuclei, and necrotic nodules. Finally, ferulic acid decreased the expression of HIF-1α, NFκB, TNF-α, mTOR, STAT3, cMyc, and cyclin D1. In conclusion, ferulic acid is believed to possess anti-tumor properties by inhibiting HCC-induced hypoxia through the suppression of HIF-1α expression. Additionally, it helps in reducing the expression of mTOR, STAT3, cMyc, and cyclin D1, thereby slowing down tumor growth. Lastly, ferulic acid reduced hepatic tissue inflammation by downregulating NFκB and TNF-α.

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Production of Fucoxanthin from Microalgae Isochrysis galbana of Djibouti: Optimization, Correlation with Antioxidant Potential, and Bioinformatics Approaches

Mohamed Abdoul-Latif,

Ainane,

Achenani

et al. 2024

Marine Drugs

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Fucoxanthin, a carotenoid with remarkable antioxidant properties, has considerable potential for high-value biotechnological applications in the pharmaceutical, nutraceutical, and cosmeceutical fields. However, conventional extraction methods of this molecule from microalgae are limited in terms of cost-effectiveness. This study focused on optimizing biomass and fucoxanthin production from Isochrysis galbana, isolated from the coast of Tadjoura (Djibouti), by testing various culture media. The antioxidant potential of the cultures was evaluated based on the concentrations of fucoxanthin, carotenoids, and total phenols. Different nutrient formulations were tested to determine the optimal combination for a maximum biomass yield. Using the statistical methodology of principal component analysis, Walne and Guillard F/2 media were identified as the most promising, reaching a maximum fucoxanthin yield of 7.8 mg/g. Multiple regression models showed a strong correlation between antioxidant activity and the concentration of fucoxanthin produced. A thorough study of the optimization of I. galbana growth conditions, using a design of experiments, revealed that air flow rate and CO2 flow rate were the most influential factors on fucoxanthin production, reaching a value of 13.4 mg/g. Finally, to validate the antioxidant potential of fucoxanthin, an in silico analysis based on molecular docking was performed, showing that fucoxanthin interacts with antioxidant proteins (3FS1, 3L2C, and 8BBK). This research not only confirmed the positive results of I. galbana cultivation in terms of antioxidant activity, but also provided essential information for the optimization of fucoxanthin production, opening up promising prospects for industrial applications and future research.

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Ferulic acid interventions ameliorate NDEA-CCl4-induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats

Cited by 3 publications

References 51 publications

Syringic acid through reduction of inflammation, oxidative injury, and downregulation of NF-κB-IL-6 pathway ameliorates HFD-induced pulmonary toxicity in male Wistar rats

Syringic acid through reduction of inflammation, oxidative injury, and downregulation of NF-κB-IL-6 pathway ameliorates HFD-induced pulmonary toxicity in male Wistar rats

Ferulic acid inhibits tumor proliferation and attenuates inflammation of hepatic tissues in experimentally induced HCC in rats

Production of Fucoxanthin from Microalgae Isochrysis galbana of Djibouti: Optimization, Correlation with Antioxidant Potential, and Bioinformatics Approaches

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