Effect of Galactooligosaccharides on Calcium Absorption in Rats.

Chonan, Osamu; Watanuki, Masaaki

doi:10.3177/jnsv.41.95

Cited by 76 publications

(49 citation statements)

References 25 publications

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“…It is known that low pH in the intestine suppresses the production of putrid substances (Mitsuoka, 1982), and promotes mineral absorption (Rémésy et al, 1993;Chonan & Watanuki, 1995). Propionate and butyrate also improved constipation by stimulating the intestinal inner wall and promoting intestinal peristalsis (Yajima, 1984;Okazaki et al, 1990).…”

Section: Resultsmentioning

confidence: 99%

In Vitro Digestibility and Fermentation of Mannooligosaccharides from Coffee Mannan

Asano

Hamaguchi

Fujii

et al. 2003

FSTR

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Digestibility of mannooligosaccharides obtained from thermal hydrolysis of spent coffee grounds was examined by in vitro digestion method. Mannooligosaccharides were resistant to human salivary ␣-amylase, artificial gastric juice, porcine pancreatic enzymes and rat intestinal mucous enzymes. Fermentation products of mannooligosaccharides in human large intestine were estimated by in vitro fecal incubation method. Mannooligosaccharides were fermented by human fecal bacteria and the products of fermentation were short chain fatty acids. Acetic, propionic and n-butyric acids were the main short chain fatty acids as end fermentation products. These results suggest that mannooligosaccharides are indigestible saccharides and are converted to short chain fatty acids in human large intestine. The short chain fatty acids are thought to improve the large intestinal environment. Moreover, they are absorbed and utilized by the host as an energy source.

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Section: Resultsmentioning

confidence: 99%

In Vitro Digestibility and Fermentation of Mannooligosaccharides from Coffee Mannan

Asano

Hamaguchi

Fujii

et al. 2003

FSTR

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“…For details of diet, see Table 1 in the large intestine. Also, GOS-feeding increased the absorption of the minerals 4,5,6 . Chonan and Watanuki 4,5,6 showed the stimulating effects of GOS on calcium absorption may be partly associated with increased solubility of calcium and the fluid content in the intestinal lumen.…”

Section: Discussionmentioning

confidence: 99%

“…Also, GOS-feeding increased the absorption of the minerals 4,5,6 . Chonan and Watanuki 4,5,6 showed the stimulating effects of GOS on calcium absorption may be partly associated with increased solubility of calcium and the fluid content in the intestinal lumen. In the present study, partially gastrectomy caused anemia, induced by reduced iron absorption could be partially prevented by the inclusion of GOS + PDX in the diet (Figures.…”

Section: Discussionmentioning

confidence: 99%

“…Samples were heated with 0.5 mL concentrate HNO 3 65% and 0.15 mL (30%) H 2 O 2 (Merck Brazil, São Paulo, Brazil) in closed pressurized Hostaflon tubes heated in microwave (DGT 100 PlusProvecto). The determinations of fecal iron and diet were performed in an Optic Emission IRIS-AP (Thermo Jarrell Ash) at the Laboratory of Biominerals Chemical Analyses, Campinas, São Paulo, Brazil and the calculations were: apparent iron absorption (mg/day)=iron intake (mg/ day) -fecal iron excretion (mg/day) 5 .…”

Section: Methodsmentioning

confidence: 99%

“…Animals in the sham operated group received sodium chloride 0.9% (Sanobiol Ltda, Pouso Alegre, Minas Gerais, Brazil). For feces collection, the animals were placed into individual metabolic cages, for three days in three periods at 15 th , 35 th and 55 th day of the experiment 5 .…”

Section: Experimental Groups and Dietsmentioning

confidence: 99%

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A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

Santos¹,

Tsuboi²,

Araújo³

et al. 2011

ABCD, arq. bras. cir. dig.

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headings -Prebiotics. Gastrectomy. Iron. Anemia. Rats.abstRact -Background -The ingestion of two prebiotics, galactooligosaccharide (GOS) and polydextrose (PDX), leads to an increase in iron absorption and promotes recovery from anemia in gastrectomized rats. Aim -To study whether GOS + PDX stimulate iron absorption in gastrectomized and normals rats. Methods -Rats were laparotomized (sham-operated control) and partially gastrectomized (Billroth II) in groups of 20 each. Animals from both treatments were subsequently fed a control diet (AIN-93M) or the same diet supplemented with GOS and PDX (25 g/Kg of diet each) for eight weeks. They were divided into four subgroups, i.e., sham-operated and gastrectomized without GOS + PDX, sham-operated and gastrectomized with GOS + PDX. Two rats died during the experiment. All gastrectomized rats received an intramuscular injection of vitamin B-12 every two weeks. Hematocrit (HCT) and hemoglobin concentration (HGB) were measured at the start and on day 30 and 56 days after the start of feeding. On the final day of the study, total blood was collected for determination of serum iron concentration. Results -In the diet with GOS + PDX, iron excretion in feces was significantly lower than without the prebiotics. Apparent iron absorption and serum iron was higher in the GOS + PDX fed groups (both sham operated and gastrectomized) than in the non-GOS + PDX fed groups. The HCT and HGB concentrations were significantly lower in gastrectomized rats than in the control group, however, GOS + PDX feeding improved HGB levels in this group. ConclusionThe association of the GOS + PDX increase absorption of iron in sham-operated and gastrectomized rats and still prevent postgastrectomy anemia.Resumo -Racional -Ratos gastrectomizados desenvolvem anemia, e a ingestão de galactooligossacarídeo (GOS) e a polidextrose (PDX) aumenta a absorção de ferro e promove a recuperação da anemia em ratos com deficiência de ferro. Objetivo -Avaliar se GOS e PDX estimulam a absorção de ferro em ratos gastrectomizados e normais. Métodos -Os ratos foram laparotomizadas (controle falso-operado) e parcialmente gastrectomizados (Billroth II) em grupos de 20 animais. Os animais de ambos os tratamentos foram posteriormente submetidos à dieta controle (AIN-93M) ou a mesma dieta suplementada com GOS e PDX (25 g/kg de dieta cada) durante oito semanas e divididos em quatro subgrupos: sham-operados e gastrectomizados sem GOS e PDX, sham-operados e gastrectomizados com GOS e PDX. Dois animais morreram durante o experimento. Todos os ratos gastrectomizados receberam uma injeção intramuscular de vitamina B-12 a cada duas semanas. Hematócrito (HCT) e concentração de hemoglobina (HGB) foram dosados no início e nos dias 30 e 56 dias após o início da alimentação. No último dia do estudo, o sangue total foi coletado para determinação da concentração de ferro sérico. Resultados -Na dieta com GOS e PDX a excreção de ferro nas fezes foi significativamente menor do que no grupo sem prebióticos. Absorção aparente de ferro e ferro sé...

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β‐Galactosidase, Enzymology

Nakayama

Amachi

1999

Encyclopedia of Bioprocess Technology

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Effect of Galactooligosaccharides on Calcium Absorption in Rats.

Cited by 76 publications

References 25 publications

In Vitro Digestibility and Fermentation of Mannooligosaccharides from Coffee Mannan

In Vitro Digestibility and Fermentation of Mannooligosaccharides from Coffee Mannan

A ingestão de prébioticos previne a malabsorção de ferro e anemia induzidas pela gastrectomia?: Estudo experimental em ratos

β‐Galactosidase, Enzymology

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