Effect of Functional Groups at Hole Edges on Cisplatin Release from Inside Single-Wall Carbon Nanohorns

Abstract

We incorporated cisplatin inside single-wall carbon nanohorns (NHs) and revealed that 70% of the cisplatin was released from NHs having holes with hydrogen-terminated edges when they were immersed in phosphate-buffered saline (PBS). However, only 15% was released from NHs having holes with oxygen-containing functional groups at the hole edges (NHox). Elemental analysis indicated that -COOH and -OH groups at the hole edges of NHox changed mainly to -COONa and -ONa groups by immersion in PBS. These groups decreased the practical hole diameters, which resulted in hindering the cisplatin release from NHox. This means that the release of the material from inside NHox would be controlled by chemically modifying the functional groups attached to the hole edges of NHox; thus the potential applicability of NHox to a material carrier would be enhanced.

Cisplatin functionalized single‐walled carbon nanotubes

“…The cylinder was then immersed in 28 ml of physiological solution [5]. The system was protected from light and kept at 37 °C.…”

“…Here, Cisplatin (Cis-Diamminedichloroplatinum (CDDP)) has been used. The inclusion of Cisplatin has already involved a new variety of SWCNTs: the single-wall carbon nanohorns (SWCNHs), graphitic tubes with cone shaped tips and the characteristic feature to assemble in spherical aggregates [5][6][7].…”

Development of a multiwalled carbon nanotube coated collagen dish

“…Studies of the application of carbon nanomaterials have been carried for the substrate of cell culture [1][2][3][4][5][6][7][8][9] , drug delivery systems 10,11) and medical implant materials 12,13) . Cells have high affinity to singlewalled CNTs (SWCNTs) [5][6][7]9,14) , multiwalled CNTs (MWCNTs) 2,4,[6][7][8] and other carbon nanofibers 1,3) .…”

Interfacing Functionalized Carbon Nanohorns with Primary Phagocytic Cells

“…[10][11][12][13] f-CNHs have been proposed for controlled drug release of anti-inflammatory and anticancer agents including dexamethasone, cis-platin, and doxorubicin. [3][4][5][6][7][8] Alternatively, CNHs have been modified with magnetite and administered in vivo for magnetic resonance imaging (MRI) applications. [9] These studies have been complemented by the assessment of a reduced toxicity displayed by the functionalized horns.…”