Effect of Folic Acid Supplementation on Homocysteine, Serum Total Antioxidant Capacity, and Malondialdehyde in Patients with Type 2 Diabetes Mellitus

Abstract

Pharmacological doses of folate supplementation lowered plasma homocysteine and serum malondialdehyde levels and improved serum total antioxidant capacity and folate and B12 levels in patients with type 2 diabetes.

Plasma homocysteine and total antioxidant status in diabetic chronic kidney disease and diabetic renal allograft recipients: effect of folic acid therapy

“…13,14 Folic acid has been shown to lower homocysteine levels in several studies. 8,15,16 We did not observe any significant difference in the values of total antioxidant status in diabetics with end stage kidney disease, uncomplicated diabetes mellitus, stable renal allograft recipients and healthy individuals.…”

Homocysteine induces oxidative stress in young adult central retinal vein occlusion

“…Experimental studies with animal models28 and cell culture experiments with cardiomyocytes exposed to homocysteine gave rise to an increased p38 mitogen-activated protein kinase-mediated increase in oxidative stress29 Szamosi et al 30 reported that plasma total homocysteine and TBARS levels might contribute to the high risk of coronary heart disease. Correlation between elevated levels of homocysteine and oxidative stress was reported in many clinical conditions such as type 2 diabetes mellitus,31 schizophrenia32 and age-related macular degeneration 8…”

“…Therefore, supplementation of folate and B 12 , which can reduce homocysteine levels, can be beneficial in reducing the oxidative stress in CRVO. Folic acid supplementation is reported to reduce the oxidative stress markers as well as the homocysteine levels in type 2 diabetes mellitus patients,31 smokers41 cases of hypertension 42. Although the beneficial effect of such vitamin supplements in cardiovascular disease is controversial,43 44 young adult CRVO cases in the absence of an abnormal lipid profile can be an ideal group to evaluate the homocysteine and oxidative stress-lowering effect through these supplements.…”

Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency

“…It was suggested that low B12 status with low folate was a potential triggering factor for developing hyperhomocysteinemia and oxidative stress in adults with type 2 diabetes (8). In a similar study, it was found that treatment with folate supplementation lowered levels of plasma homocysteine and serum malondialdehyde and improved TAS and B12 serum levels in patients with type 2 diabetes mellitus (13). In another study, Qureshi et al suggested that vitamin B12 deficiency was associated with neurotoxicity in Parkinson disease cases by enhancing oxidative stress (14).…”