Effect of fluoxetine on an experimental model of diabetes-induced neuropathic pain perception in the rat

Abstract

The aim of the present study was to study the effect of chronic treatment (9 weeks) of fluoxetine (20 mg/kg p.o.) a selective serotonin reuptake inhibitor on blood glucose level and in prevention of diabetic neuropathic pain perception. Evaluation of diabetic neuropathy was performed after 9 weeks of single injection of streptozotocin (70 mg/kg i.v.) in rats. Blood glucose level, glycated haemoglobin, grip strength, pain sensitivity and threshold in diabetic rats were measured at the end of 9 weeks. The results of the present study indicate that the 9 weeks treatment of fluoxetine demonstrates hypoglycemic effect; it marked decreases the blood glucose level in diabetic treated animals. There was also decrease in the grip strength in diabetic rat indicates to induction of neuropathy or nerve damage. Fluoxetine increase the grip strength of diabetic rats. There was also found loss of pain perception in diabetes rats which measured using hot plate and tail flick methods. Fluoxetine increases the licking time and withdrawal latency in hot plate and tail flick test respectively indicates the presence of pain perception and prevention of nerve damage demonstrates its protective effect in diabetic neuropathy. Our study concludes the chronic treatment of fluoxetine significantly decreases the glycemic level as well as it protected from the development of diabetic neuropathy.

Anti-depressant effect of hesperidin in diabetic rats

“…In accordance with this finding, Tembhurne and Sakarkar (2011) have revealed that a 9 week treatment with Flu (20.0 mg·kg −1 , per oral) decreased the glycaemic index and protected STZ-induced diabetic rats from diabetic neuropathy. Moreover, clinical studies have reported the effectiveness of Flu in reducing the severity of depression as well as hyperglycaemia in diabetic patients, leading to better glycaemic control (Goodnick 2001;Khazaie et al 2011).…”

Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats

“…Park et al (33), revealed that 90% pancreatic resection increased glucose clearance and decreased blood insulin levels following 8 weeks of fluoxetine treatment. Tembhurne et al (34) reported that fluoxetine reduced the levels of FBG and improved glucose tolerance in rats with STZ-induced diabetes. In summary, fluoxetine may reduce blood glucose and body weight loss, and improve insulin resistance; however, the underlying molecular mechanisms remain unknown.…”

The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats

“…It has been observed that there is loss of pain perception, and it is thought to be due to nerve damage and induction of peripheral neuropathy. 18 …”