Effect of Flavonoids Extracted from Black Cumin (Nigella sativa) and Vitamin E in Ameliorating Hepatic Damage Induced by Sodium Nitrate in adult male rats

Al-Okaily, Baraa Najim; Mohammed, Rawya Shaker; Al-Mzain, Kahtan A.; Khudair, Khalisa Khadim

doi:10.30539/iraqijvm.v36i0e.413

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…14 This finding is consistent with animal models, as the aqueous extract of N. sativa had anti-inflammatory and analgesic antipyretic effects in albino Wistar rats and albino Swiss mice. 40 Thymoquinone is one of the major compounds of N. sativa, 41 with analgesic, 42 anti-inflammatory, 43 antioxidative, 44 and antioxidative stress effects (Bhandari, 2014). Nigella sativa inhibits inflammatory mediators such as prostaglandins and leukotrienes, macrophage function, NK antitumor activity, amends splenocyte proliferation and Th1/Th2 cytokine profile.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Herbal Medicines on Cyclic Mastalgia: A Systematic Review on Meta-analysis

Mirzaee

Fakari

Babakhanian

et al. 2022

Rev Bras Ginecol Obstet

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Objective Different drugs are used to treat mastalgia, such as danazol and bromocriptine, and both are associated with side effects, due to which most of women and healthcare providers are interested in herbal medicines. Therefore we aim to study the effectiveness of phytoestrogens on the severity of cyclic mastalgia. Methods To carry out the present study, English electronic resources such as the Cochrane Library, ISI Web of Science, Scopus, and PubMed were used systematically and with no time limitation up to February 10, 2020. Results In total, 20 studies were included in the present meta-analysis. The results of the meta-analysis showed that herbal medicines versus the control group (standard mean difference [SMD] = - 0.585; 95% confidence interval [CI]: - 0.728–- 0.44; heterogeneity; p = 0.02; I2 = 42%), herbal medicines versus the B group (SMD = - 0.59; 95%CI: - 0.75–- 0.44; heterogeneity; p = 0.03; I2 = 42%), and its subgroups, such as phytoestrogen (SMD = - 0.691; 95%CI: - 0.82–- 0.55; heterogeneity; p = 0.669; I2 = 0%), Vitex-agnus-castus (SMD = - 0.642; 95%CI: - 0.84–- 0.44; p < 0.001; p = 203; I2 = 32%), flaxseed (SMD = - 0.63; 95%CI: - 0.901–- 0.367; p = 0.871; I2 = 0%), and evening primrose (SMD= - 0.485; 95%CI:- 0.84–- 0.12; p = 0.008; heterogeneity; p = 0.06; I2 = 56%] may have effective and helpful effects on improving cyclic breast mastalgia. Also, chamomile, isoflavone, cinnamon, and nigella sativa significantly reduced mastalgia symptoms. Conclusion Herbal medicines and their subgroups may have effective and helpful effects on improving cyclic breast mastalgia. The findings of our meta-analysis must be done cautiously because low methodological quality in some evaluated studies of this systematic review.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Herbal Medicines on Cyclic Mastalgia: A Systematic Review on Meta-analysis

Mirzaee

Fakari

Babakhanian

et al. 2022

Rev Bras Ginecol Obstet

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From Molecular Pathology of COVID 19 to Nigella Sativum as a Treatment Option: Scientific Based Evidence of Its Myth or Reality

Atif

Naz

Akhtar

et al. 2021

Chin. J. Integr. Med.

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COVID-19 virus is a causative agent of viral pandemic in human beings which specifically targets respiratory system of humans and causes viral pneumonia. This unusual viral pneumonia is rapidly spreading to all parts of the world, currently affecting about 105 million people with 2.3 million deaths. Current review described history, genomic characteristics, replication, and pathogenesis of COVID-19 with special emphasis on Nigella sativum ( N. sativum ) as a treatment option. N. sativum seeds are historically and religiously used over the centuries, both for prevention and treatment of different diseases. This review summarizes the potential role of N. sativum seeds against COVID-19 infection at levels of in silico , cell lines and animal models. Electronic Supplementary Material Supplementary material (Appendixes 1) is available in the online version of this article at 10.1007/s11655-021-3311-z.

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Novel Insight into Potential Leishmanicidal Activities of Transdermal Patches of Nigella Sativa: Formulation Development, Physical Characterizations, and In vitro/In vivo Assays

Khan

Asmat

Khan

et al. 2021

ASSAY and Drug Development Technologies

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Cutaneous Leishmaniasis (CL) is the most common type of Leishmaniasis which annually affects 1.5 million people worldwide. About 90% of cases are reported from countries such as Iran, Afghanistan, Pakistan, Iraq, and Saudi Arabia. The purpose of the present study was to fabricate transdermal patches of Nigella sativa (NS), characterize and to check its in vitro in vivo anti-Lieshmanial activity. Hydroalcohlic extract was analyzed for preliminary phytochemicals. Five formulations of transdermal patches (NS1, NS2, NS3, NS4 and NS5) were prepared by solvent evaporation method. The optimized formulation NS5 was characterized for FTIR, smoothness, brittleness, clarity, thickness, folding endurance, uniformity of weight, percent moisture content, in-vitro drug release, release kinetics, ex vivo drug permeation and invitro anti-Lieshmanial activity. In vivo anti-Lieshmanial activity was assessed in 30 patients (n = 30) suffering from CL. The FTIR studies showed no incompatibility among the active extract and polymers. In vitro anti-Lieshmanial assay was 194.6 ± 1.88 % as compared to standard drug (p > 0.05) and in vivo anti-Lieshmanial activity was 75 %. The drug release after 24 hours was 87.0 ± 0.94% in NS5 which showed non-Fickian diffusion mechanism while drug permeation across rabbit skin after 24 hours was up to 80.0 ± 0.91%. The results concluded that problems related to the medications parenterally used for Lieshmanial treatment can be managed by applying extract of Nigella sativa seeds in the form of transdermal patch. parasitic, anti-in ammatory, anti-cancer, antibacterial and antifungal activity. 15 Based on the above justi cation, the present study was designed with the aim to formulate and characterize transdermal patches of Nigella sativa extract for possible anti Lieshmanial activity in vitro and in vivo. Materials And MethodsMethanol, HPMC, Ethyl Cellulose, PVP, PVA (polymers), Propylene glycol, Tween-80, DMSO were purchased from Sigma Aldrich, Germany. Nigella sativa seeds Extract were purchased from local market of D. I. Khan, Pakistan. Benedict's reagent & Wagner's reagent (Iodine Reagent), Chloroform and Distilled Water were obtained from

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Effect of Flavonoids Extracted from Black Cumin (Nigella sativa) and Vitamin E in Ameliorating Hepatic Damage Induced by Sodium Nitrate in adult male rats

Cited by 4 publications

References 46 publications

The Effectiveness of Herbal Medicines on Cyclic Mastalgia: A Systematic Review on Meta-analysis

The Effectiveness of Herbal Medicines on Cyclic Mastalgia: A Systematic Review on Meta-analysis

From Molecular Pathology of COVID 19 to Nigella Sativum as a Treatment Option: Scientific Based Evidence of Its Myth or Reality

Novel Insight into Potential Leishmanicidal Activities of Transdermal Patches of Nigella Sativa: Formulation Development, Physical Characterizations, and In vitro/In vivo Assays

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