Effect of fenugreek (Trigonella foenum-graecum) on experimentally induced diabetes mellitus in male rabbits

Abstract

The study was conducted to investigate the effect of orally administered fenugreek on some biochemical parameters in diabetic male rabbits experimentally induced by intra peritoneal injection of alloxan monohydrate 75 mg/kg. Twenty five male local breed rabbits were divided into 5 equal groups; G1 normal control group, G2 diabetic non-herb treated, G3 normal rabbit treated with the herb. While, each of G4 and G5 were diabetic rabbits treated with 2 and 3g/day single oral dose of fenugreek for 30 consecutive days respectively. Blood sample were taken at zero day, 2 weeks and 4 weeks for estimation of serum glucose, cholesterol, triglyceride, ALT, and AST. At the end of the experiment, animals were sacrificed in order to prepare liver tissue homogenate to calculate the level of Malondialdehyde (MDA) and glutathione (GSH) to explore the role of fenugreek as antioxidant herb. Results were revealed an increase in serum glucose, cholesterol, triglyceride, ALT, AST, and MDA level and reduced glutathione level in G2. While, oral administration of fenugreek showed a significant reduction in total lipids and serum sugar in diabetic rabbits and have no any adverse effect on the main parameters of the body, the herb play a great role as antioxidant factor as indicated by increasing GSH level and reduce MDA level.

Anti-hyperglycemic and anti-hyperlipidemic effects of Panax ginseng root extract in alloxan induced diabetic rats

“…Increased in blood creatinine level indicates impaired renal function. Elevated creatinine level in diabetes is associated with nephropathy (Salih, 2012).…”

Synergistic Effect of Extracts of Ginkgo Biloba Leaf and Panax Ginseng Root on Carbohydrate and Lipid Metabolism Gene Expression in Alloxan Induced Diabetic Rats

“…Liver enzymes (AST and ALT) are important bio-marker to identify liver diseases; and literature supports the arguments that these said enzymes are linked to the development of diabetic complications (Kunutsor et al, 2013). High creatinine concentration in blood is an indicator of renal dysfunction (Salih, 2012). Table 1.…”

Growth Performance Indices of New Zealand White Rabbits Administered Panax ginseng Extracts

“…Pre-treatment of broilers with P. ginseng extracts has been reported to ameliorate selenium induced hepatic toxicity, through its antioxidant effect on the liver, leading to its recommendation as a neutraceutical in poultry farms (Shimaa, 2014). In rats, P. ginseng was reported to attenuate the adverse effects of flutamide on the testis (Oremosu et al, 2013), while it reduced total lipids in diabetic rabbits (Salih, 2012). Beside the beneficial effects of P. ginseng in animal models, numerous other benefits of P. ginseng have been widely documented (Lakshmi et al, 2011) and are being mainly explored in the herbal medicine.…”