Effect of feeding tuna oil or soyabean oil as supplements to sows in late pregnancy on piglet tissue composition and viability

Rooke, John; Bland, I.M.; Edwards, S.A.

doi:10.1017/s0007114598001329

Cited by 49 publications

(39 citation statements)

References 29 publications

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“…The present study also revealed that the proportions of total VL_n3-PUFA in ewe plasma were increased and the proportions of total n6-PUFA were decreased by feeding the FM-supplemented diet. In an experiment conducted by Rooke et al (1998), feeding tuna oil to sows increased the VL_n3-PUFA, especially 20:5n3 and 22:6n3, primarily at the expense of 18:2n6.…”

Section: Discussionmentioning

confidence: 99%

Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

Chee¹

2012

American Journal of Animal and Veterinary Sciences

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Problem statement:The very long chain n-3 polyunsaturated fatty acids (>18C) cannot be adequately synthesized by ruminant tissues to meet their requirements; therefore, their concentration in body depends on the supply through feed. It may be possible to improve the essential fatty acid status of ruminant animals, during gestation by manipulating the maternal diet with fishmeal (FM). The objectives of this research were to (1) determine the effect of fishmeal supplementation on the plasma fatty acid profile of ewes during late gestation and (2) determine the status of the plasma docosahexaenoic acid (22:6n3) of lambs born to these ewes. Approach: Eight gestating ewes [RideauArcott, 97±5 kg initial body weight, 100 days of gestation] were used in a completely randomized design. Ewes were individually-housed and fed either a control diet (supplemented with soybean meal) or a fishmeal supplemented diet. Blood samples were collected via jugular venipuncture for plasma fatty acids analysis on 100, 114, 128 and 142 days of gestation after morning feeding. Blood samples from the lambs were also collected via jugular venipuncture immediately after birth and before receiving their mothers' colostrum. Plasma fatty acids were analyzed by gas-liquid chromatography.

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Section: Discussionmentioning

confidence: 99%

Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

Chee¹

2012

American Journal of Animal and Veterinary Sciences

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“…Supplementing the sow diet with lipids during pregnancy not only alters the lipid composition of the developing pig foetuses (Rooke et al, 1998), but also subsequent milk composition . As observed in humans (Innis, 2004), the fatty acid composition of the milk mirrors that of the type of oil that is added to the sow diet, which can subsequently influence neonatal outcome in modern domestic breeds .…”

Section: Litten-brown Corson and Clarkementioning

confidence: 99%

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

Litten-Brown

Corson

Clarke

2010

Animal

144

136

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The aim of this review article is to provide an overview of the role of pigs as a biomedical model for humans. The usefulness and limitations of porcine models have been discussed in terms of metabolic, cardiovascular, digestive and bone diseases in humans. Domestic pigs and minipigs are the main categories of pigs used as biomedical models. One drawback of minipigs is that they are in short supply and expensive compared with domestic pigs, which in contrast cost more to house, feed and medicate. Different porcine breeds show different responses to the induction of specific diseases. For example, ossabaw minipigs provide a better model than Yucatan for the metabolic syndrome as they exhibit obesity, insulin resistance and hypertension, all of which are absent in the Yucatan. Similar metabolic/physiological differences exist between domestic breeds (e.g. Meishan v. Pietrain). The modern commercial (e.g. Large White) domestic pig has been the preferred model for developmental programming due to the 2-to 3-fold variation in body weight among littermates providing a natural form of foetal growth retardation not observed in ancient (e.g. Meishan) domestic breeds. Pigs have been increasingly used to study chronic ischaemia, therapeutic angiogenesis, hypertrophic cardiomyopathy and abdominal aortic aneurysm as their coronary anatomy and physiology are similar to humans. Type 1 and II diabetes can be induced in swine using dietary regimes and/or administration of streptozotocin. Pigs are a good and extensively used model for specific nutritional studies as their protein and lipid metabolism is comparable with humans, although pigs are not as sensitive to protein restriction as rodents. Neonatal and weanling pigs have been used to examine the pathophysiology and prevention/treatment of microbial-associated diseases and immune system disorders. A porcine model mimicking various degrees of prematurity in infants receiving total parenteral nutrition has been established to investigate gut development, amino acid metabolism and non-alcoholic fatty liver disease. Endoscopic therapeutic methods for upper gastrointestinal tract bleeding are being developed. Bone remodelling cycle in pigs is histologically more similar to humans than that of rats or mice, and is used to examine the relationship between menopause and osteoporosis. Work has also been conducted on dental implants in pigs to consider loading; however with caution as porcine bone remodels slightly faster than human bone. We conclude that pigs are a valuable translational model to bridge the gap between classical rodent models and humans in developing new therapies to aid human health.

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“…Moreover, the inclusion of n-3 PUFA in the maternal diet can influence the fatty-acid composition of offspring. It is generally accepted that the effect of the maternal diet on the fatty-acid composition of progeny is due to direct incorporation of the fatty acids (Rigau et al, 1995;Rooke et al, 1998;Lauridsen and Jensen, 2007). However, animal tissues also have the ability to synthesise long-chain fatty acids from dietary precursors (Brenner, 1974;Sprecher, 2000;Moghadasian, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Missotten

Smet

Raes

et al. 2009

Animal

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The present study investigated whether enrichment of the pig maternal diet with n-3 polyunsaturated fatty acids (PUFA) affects the fatty-acid composition of female piglets via enhancing of expression of the lipogenic enzymes D5-desaturase (D5d) and D6-desaturase (D6d). The sows (50% Landrace 3 50% Large White) were fed a control diet or one of the experimental diets starting at day 45 in gestation. The experimental diets were supplemented either with linseed oil or fish oil, whereas the control diet contained palm oil. Expression of D5d and D6d, and fatty-acid composition was determined by Western blotting and gas-liquid chromatography, respectively, in muscle, subcutaneous adipose tissue and liver. The highest D5d protein expression was observed in the piglets' muscle, followed by subcutaneous adipose tissue, with the lowest level in the liver. Expression of D6d in the piglets' tissues followed an opposite pattern, and was highest in the liver, followed by subcutaneous adipose tissue, with the lowest level in muscle. Supplementation of the maternal diet with fish oil or linseed oil increased the level of n-3 PUFA of the piglets in a tissue-specific manner. The response of D6d and D5d protein expression in female piglets, with average birth weight 2.4 kg, to the dietary manipulation was also tissue-specific. It is suggested that the increase in n-3 PUFA content in the progeny was related, at least partially, to the activation of D6d and D5d expression.

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Effect of feeding tuna oil or soyabean oil as supplements to sows in late pregnancy on piglet tissue composition and viability

Cited by 49 publications

References 29 publications

Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

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