Effect of extracts of traditional Chinese medicines on anti-tyrosinase and antioxidant activities

Hsieh, T. F.; Chang, Yaw-Nan; Liu, Bing-Lan

doi:10.5897/jmpr2015.5953

Cited by 11 publications

(2 citation statements)

References 26 publications

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“…The tyrosinase inhibitory activity of the A. niger -fermented extracts was higher than that of the unfermented extracts and the positive control, arbutin (IC 50 , 0.056 ± 0.012 mg/mL), but lower than that of kojic acid (IC 50 , 0.018 ± 0.005 mg/mL). Hsieh et al (2015) also observed a similar tendency for many traditional Chinese medicine products [34]. The DPPH radical scavenging activity and reducing power of the A. niger -fermented extracts were significantly superior to those of the control BHT (IC 50 , 1.13 ± 0.31 mg/mL) and BHT (IC 50 , 3.06 ± 0.51 mg/mL), respectively.…”

Section: Resultsmentioning

confidence: 76%

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Chen

Cheng

et al. 2018

BioMed Research International

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This study intended to improve physiological characteristics of Magnolia officinalis bark (MOB) extracts by Aspergillus niger fermentation. M. officinalis bark was extracted using distilled water, 95% ethanol, and methanol, and it was then fermented by A. niger. The physiological characteristics of the fermented extracts, namely, tyrosinase inhibitory activity, antioxidant activity, antibacterial activity, and anti-skin-aging activity, were evaluated and compared with those of unfermented extracts. To determine the safety of the fermented extracts, their cytotoxicity was analyzed by measuring the cell viability of CCD-966SK and human epidermal melanocytes (HEMn) after exposure. The fermented methanol extract exhibited the highest antityrosinase activity, total phenolic content, and antioxidant activity. The total phenolic content of the extracts fermented by A. niger was 3.52 times greater than that of the unfermented extracts. The optimal IC50 values for tyrosinase inhibition and 2,2-diphenyl-1-picrylhydrazyl (DPPH) removal by the A. niger-fermented extracts were 30 and 12 μg/mL, respectively. The fermented methanol extracts inhibited skin-aging-related enzymes such as collagenase, elastase, MMP-1, and MMP-2. Compared with the unfermented extracts, the fermented extracts also contained greater antibacterial activity against tested stains including MRSA. These results could be attributed to an increase in the concentration of original active compounds and the biosynthesis of new compounds during fermentation. In cytotoxicity assays, the A. niger-fermented extracts were nontoxic to CCD-966SK cells, even at 500 μg/mL. Hence, in general, methanol-extracted M. officinalis fermented by A. niger for 72 h has the most active antioxidant, skincare, or antiaging compounds for healthy food or cosmetics applications.

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Section: Resultsmentioning

confidence: 76%

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Chen

Cheng

et al. 2018

BioMed Research International

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“…Galangal can be used in various skin diseases treatment [5]. Galangal has a number of antioxidants that can protect the skin from premature aging [6]. Galangal antioxidants are able to get rid of toxins from the body and improve blood circulation [4].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Properties of Skin Care Cream Containing Essential Oil of Galangal

Sanjaya¹,

Ismono²,

Taufikurohmah³

et al. 2018

Proceedings of the Seminar Nasional Kimia - National Seminar on Chemistry (SNK 2018)

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A research has been conducted on development and physicochemical characterization of skin care cream containing essential oils of galangal. The skin care cream containing essential oils of galangal developed consists of a red galangal cream that utilizes the essential oil ingredients extracted from red galangal rhizomes and white galangal cream that utilizes the essential oil ingredients extracted from the white galangal rhizomes. Cream is made by homogeneously mixing each of the red galangal essential oils and each of the white galangal essential oils with basic cream in concentration variations of 0.25%, 0.50%, 0.75%, 1.00%, and 1.50%. Each galangal cream then tested its physicochemical character and the acceptance level of its panellists. The results of this study are two types of galangal cream products, namely red galangal cream and white galangal cream. The galangal cream is a mixture that looks homogeneous, with white to slightly brownish colour, and has a typical odor of galangal. Each type of creams having a density range of 0.94 g/cm 3 to 0.96 g/cm 3 is a physically viscous mixture, with viscosity ranging from 37,007 cps to 37,413 cps for red galangal creams and 37,055 cps to 37,453 cps for white galangal creams. Spreading capacity of galangal creams is about 40.50 cm 2 to 44.50 cm 2 , wider 0.50 cm 2 to 4.50 cm 2 compared to basic cream which have spreading capacity 40.00 cm 2. The results of the hedonic sensory test show that 75%-80% or more panellists are quite acceptable up to strongly accept the physicochemical character of each red galangal creams and white galangal creams.

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High‐resolution monophenolase/diphenolase/radical scavenging profiling for rapid screening of natural whitening candidates from Rosa rugosa cv. ‘Plena’

Wen

Quan

Qiu

et al. 2023

J of Separation Science

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Antioxidants and tyrosinase inhibitory components were successfully screened and separated from Rosa rugosa cv. 'Plena' by high-performance liquid chromatography microfractionation bioactive screening combined with several separation and purification methods. Ethyl acetate extract of Rosa rugosa cv.'Plena' showed high antioxidant activity and tyrosinase inhibitory activity. Highspeed countercurrent chromatography, silica gel column chromatography, and semi-preparative high-performance liquid chromatography were used for the preparative separation of four bioactive components from ethyl acetate extract. Two tyrosinase-inhibiting active substances, flavogallonic acid, and N 1 -N 5 -N 10tri-4-p-coumaroylspermidine, were isolated from Rosa rugosa cv. 'Plena', and they showed great monophenolase inhibition activity (half-maximal inhibitory concentration: 664.60 and 23.77 μg/ml, respectively) and excellent diphenolase inhibition activity (half-maximal inhibitory concentration: 23 614.61 and 16.80 μg/ml, respectively). Meanwhile, gallic acid, flavogallonic acid, and ellagic acid were shown to have excellent 1,1-diphenyl-2-picryl-hydrazyl antioxidant activity (half maximal inhibitory concentration: 6.66, 20.17, and 13.45 μg/ml), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) antioxidant activity (half maximal inhibitory concentration: 3.53, 3.83, and 2.78 μg/ml). Molecular docking revealed that flavogallonic acid and N 1 -N 5 -N 10 -tri-4-p-coumaroylspermidine had a strong binding affinity (-9.3 and -10 kcal/mol, respectively) to tyrosinase through hydrogen bonding and hydrophobic interactions.

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Effect of extracts of traditional Chinese medicines on anti-tyrosinase and antioxidant activities

Cited by 11 publications

References 26 publications

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Evaluation of Tyrosinase Inhibitory, Antioxidant, Antimicrobial, and Antiaging Activities of Magnolia officinalis Extracts after Aspergillus niger Fermentation

Phytochemical Properties of Skin Care Cream Containing Essential Oil of Galangal

High‐resolution monophenolase/diphenolase/radical scavenging profiling for rapid screening of natural whitening candidates from Rosa rugosa cv. ‘Plena’

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