Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India

Yasmin, Shahla; Ranjan, Sumeet; Hilaluddin,; D’Souza, Doris H.

doi:10.1080/02772248.2013.847619

Cited by 12 publications

(4 citation statements)

References 3 publications

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“…Fluoride was found above the standard permissible limit of BIS (1.5mg/l) at all the sites during the study period. Results were in accordance to Gouri and Choudhary (2017) and Yasmin et al (2013). Disintegration of fluorite mineral from the parent rocks is favoured by alkaline range of pH (between 7.6 and 8.6) (Saxena and Ahmed, 2001).…”

Section: 𝑊𝑄𝐼 =supporting

confidence: 75%

Assessment of groundwater quality of two selected villages of Nawada district of Bihar using water quality index

Ruhela¹,

Singh

Ahamad

2021

ECJ

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Unplanned discarding of industrial effluent, sewage, domestic and industrial solid waste, unwise use of insecticides, herbicides, pesticides, and fertilizer in agriculture are the major causes of groundwater quality reduction. In the present paper groundwater quality of the two selected village of Rajauli subdivision of Nawada district of Bihar was assessed using water quality index (WQI). The samples were figured out for the parameters such as temperature, pH, electrical conductivity (EC), total dissolved solids (TDS), alkalinity, dissolved oxygen (DO), total hardness (TH), chloride, calcium (Ca), magnesium (Mg), biochemical oxygen demand (BOD), and fluoride. All the parameters were found below the standard limits of Bureau of Indian Standard (BIS, 2012) except total hardness (328.1mg/l to 346.6mg/l), calcium (105.3mg/l to 122.6mg/l), magnesium (46.1mg/l to 55.7mg/l) and fluoride (4.8 to 4.9mg/l). Fluoride was observed more than 3 times than the standard permissible limit (1.5mg/l). Water quality index (WQI) was also applied on the obtained data to make it easy to understand. Based on WQI (including the fluoride), all the four sites fall in unfit for drinking category (250.79, 258.78, 281.78, 247.30) and in poor to very poor category (80.23, 88.19, 88.59, 64.60) excluding the fluoride from WQI calculation. Both the values of WQI shows that fluoride alone is not responsible for the degraded quality of water but other high concentration of salts is also responsible.

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Section: 𝑊𝑄𝐼 =supporting

confidence: 75%

Assessment of groundwater quality of two selected villages of Nawada district of Bihar using water quality index

Ruhela¹,

Singh

Ahamad

2021

ECJ

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“…Consistent with this, several in vitro studies have shown a synergistic effect of F − and TSH on adenylate cyclase activity resulting in increased cAMP production [253,254]. Evidence from human studies also show that F − induces TSH production [140,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269]. In this scenario, a positive feedback loop exists that may amplify the effects of TSH and F − on cAMP activity, which may explain the synergistic effect of F − and TSH on cAMP production.…”

Section: Molecular Mechanisms By Which Fluoride Inhibits Na+ K+-amentioning

confidence: 67%

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Waugh¹

2019

IJERPH

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In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the expression of genes and the activity of glycolytic enzymes, metalloenzymes, hormones, proteins, neuropeptides and cytokines, as well as biological interface interactions that rely on the bioavailability of chemical elements magnesium and manganese to modulate ATP and Na + , K + -ATPase enzyme activity. Taken together, the findings of this study provide unprecedented insights into the molecular mechanisms and biological pathways by which F inhibits Na + , K + -ATPase activity and contributes to the etiology and pathophysiology of diseases associated with impairment of this essential enzyme. Moreover, the findings of this study further suggest that there are windows of susceptibility over the life course where chronic F exposure in pregnancy and early infancy may impair Na + , K + -ATPase activity with both short- and long-term implications for disease and inequalities in health. These findings would warrant considerable attention and potential intervention, not to mention additional research on the potential effects of F intake in contributing to chronic disease.

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“…The deficient thyroid function with elevated TSH at high fluoride exposure was reported in both children and adults in fluoride endemic areas in India since 2005 [110][111][112][113]. According to Susheela et al, 47% of children living in a New Delhi neighborhood with an average water fluoride level of 4.37 mg F/L have evidence of clinical hypothyroidism attributable to fluoride [111].…”

Section: Disturbances Of the Thyroid Glandmentioning

confidence: 99%

Mechanisms of Fluoride Toxicity: From Enzymes to Underlying Integrative Networks

Strunecká

Strunecký

2020

Applied Sciences

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Fluoride has been employed in laboratory investigations since the early 20th century. These studies opened the understanding of fluoride interventions to fundamental biological processes. Millions of people living in endemic fluorosis areas suffer from various pathological disturbances. The practice of community water fluoridation used prophylactically against dental caries increased concern of adverse fluoride effects. We assessed the publications on fluoride toxicity until June 2020. We present evidence that fluoride is an enzymatic poison, inducing oxidative stress, hormonal disruptions, and neurotoxicity. Fluoride in synergy with aluminum acts as a false signal in G protein cascades of hormonal and neuronal regulations in much lower concentrations than fluoride acting alone. Our review shows the impact of fluoride on human health. We suggest focusing the research on fluoride toxicity to the underlying integrative networks. Ignorance of the pluripotent toxic effects of fluoride might contribute to unexpected epidemics in the future.

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Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India

Cited by 12 publications

References 3 publications

Assessment of groundwater quality of two selected villages of Nawada district of Bihar using water quality index

Assessment of groundwater quality of two selected villages of Nawada district of Bihar using water quality index

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Mechanisms of Fluoride Toxicity: From Enzymes to Underlying Integrative Networks

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