Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion

Abstract

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720° degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion.

Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats

“…In addition, they found a higher MDA level in this surgical group than in the other groups. Besides, they observed both biochemical and histological improvements in the groups treated with etoricoxib (Yapanoglu et al., 2017). These findings suggest that ROS may contribute to the generation of inflammatory cytokines that lead to testicular atrophy, germ cell apoptosis, and spermatogenesis destruction during testicular I/R.…”

“…They also found that ghrelin treatment significantly attenuated the testicular TNF‐α and IL‐6 levels compared to the untreated animals, but had no significant effect on the IL‐1 β levels (Taati et al., 2015). Yapanoglu et al (2017) conducted a study on the effects of etoricoxib on testicular I/R injury induced by torsion‐detorsion. They carried out histopathological, gene expression and biochemical analyses on testicular tissues.…”

Ameliorative effect of nerolidol on cyclophosphamide‐induced gonadal toxicity in Swiss Albino mice: Biochemical‐, histological‐ and immunohistochemical‐based evidences

“…During the stressful or inflammatory phase, these MPO are released into the extracellular space and forms hypochlorous acid (HOCl) by using H 2 O 2 and Cl (Adedara et al, ). Released MPO also oxidises tyrosine to tyrosyl radical and produces NO 2 (nitrodioxide) (Yapanoglu et al, ). Thus, HOCl, tyrosyl radical, NO 2 and MPO are collectively involved in the production of inflammatory cytokines (Aratani, ).…”

Theoretical Investigation of the Molecular Structure and Molecular Docking of Etoricoxib

“…12 Furthermore, studies have demonstrated that this molecule exhibits antioxidant and anti-inflammatory properties, suggesting its benefits in temporary middle cerebral artery occlusion-related ischemia, testicular and ovarian ischemia reperfusion damage. 5,13,14 Here, it is interesting to mention that the antioxidant activity of a compound is measured by their ability/capacity of transferring a hydrogen atom or an electron to reactive species. 15 Thus, electronic parameters such as: electronegativity, electrophilic index, hardness, softness, ionization potential, bond dissociation enthalpy and electron affinity may be used to evaluate this capacity.…”