Effect of ethosomal minoxidil on dermal delivery and hair cycle of C57BL/6 mice

Tu, Jiasheng; Zhuang-Qun, Yang; Xin, He; Ying, Xue; Song, Yong; Xing, Zhe; Chen, Tao

doi:10.1016/j.jdermsci.2006.09.007

Cited by 26 publications

(13 citation statements)

References 8 publications

(8 reference statements)

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“…Increase in hair weight and hair count in men with AGA after application of topical minoxidil [9,10] causes premature entry of telogen follicles into the anagen and subsequently causes prolongation of anagen to produce longer hair. Animal studies indeed showed that topical minoxidil treatment shortens the telogen and cause resting hair follicles entering into the anagen [18][19][20]. However, as far as we know, anagen prolongation effect of minoxidil has not been clearly demonstrated.…”

Section: Discussionmentioning

confidence: 97%

Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect

Kwack

Kang

Kim

et al. 2011

Journal of Dermatological Science

105

109

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Section: Discussionmentioning

confidence: 97%

Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect

Kwack

Kang

Kim

et al. 2011

Journal of Dermatological Science

105

109

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“…Ethanol may also provide the vesicles with softness and flexibility that allows ethosomes to squeeze more easily and penetrate into the deeper layers of the skin due to their increased alcohol component. Ethosomal preparations were found to be much more effective permeation enhancers than hydroethanolic solution, ethanol, or an ethanolic phospholipid solution, indicating that permeation enhancement from ethosomes was much greater than would be expected from ethanol alone [22, 29, 33, 35, 36, 42–44]. …”

Section: Discussionmentioning

confidence: 99%

“…Ethosomes were prepared by first dissolving the lipids and drug in ethanol, then adding the aqueous component slowly as a fine stream under mixing by homogenizer for 60 min [33–36]. The elastic liposomes were prepared by rotary evaporation method using Span 80 as surfactant, phospholipid, cholesterol, and drug.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes

Ghanbarzadeh

Arami

2013

BioMed Research International

164

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The aim of this study was to improve the transdermal permeation of Diclofenac sodium, a poorly water-soluble drug, employing conventional liposomes, ethosomes, and transfersomes. The prepared formulations had been characterized for the loaded drug amount and vesicle size. The prepared vesicular systems were incorporated into 1% Carbopol 914 gel, and a survey of in vitro drug release and drug retention into rat skin has been done on them using a modified Franz diffusion cell. The cumulative amount of drug permeated after 24 h, flux, and permeability coefficient were assessed. Stability studies were performed for three months. The size of vesicles ranged from 145 to 202 nm, and the encapsulation efficiency of the Diclofenac sodium was obtained between 42.61% and 51.72%. The transfersomes and ethosomes provided a significantly higher amount of cumulative permeation, steady state flux, permeability coefficient, and residual drug into skin compared to the conventional liposomes, conventional gel, or hydroethanolic solution. The in vitro release data of all vesicular systems were well fit into Higuchi model (RSD > 0.99). Stability tests indicated that the vesicular formulations were stable over three months. Results revealed that both ethosome and transfersome formulations can act as drug reservoir in skin and extend the pharmacologic effects of Diclofenac sodium.

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“…The application was first put forward by Touitou in 1996(Touitou, 1996 and was specially tailored to efficiently deliver various molecules into deep skin layers and across the skin (Ainbinder et al, 2010). Ethosomes has been studied for delivery of various drugs ranging from low molecular weight drugs such as acyclovir , minoxidil (Jun-Bo et al, 2007), tacrolimus (Li et al, 2012), ligustrazine phosphate (Shi et al, 2012), econazole nitrate (Verma & Pathak, 2012), ibuprofen (Shumilov et al, 2010) to polypeptides and gene medicines (Godin & Touitou, 2003).…”

Section: Introductionmentioning

confidence: 99%

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

et al. 2013

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The skin accumulation of therapeutic agents affects the efficiency of topical drug delivery. In this study, in vitro distribution of finasteride of ethosomes and liposomes in human cadaver skin after percutaneous delivery were investigated. Experiments were performed using modified Franz diffusion cells. Finasteride ethosomes, liposomes or hydroethanolic solutions were used as donor medium. Drug distribution at different skin layers and depths were studied by hotplate separation and frozen horizontal slicing technique. The result showed that the accumulation of finasteride in skin ranged from 9.7-24.3 mg/cm 2 at 12 or 24 hours. The ethosomes demonstrated better enhancing ability to deliver finasteride into the dermis layer than liposomes did. The finasteride concentration in the dermis layer from ethosomes was more than sevenfold higher than from liposomes. The finasteride accumulation in ethosomes group showed a distinctive reversed distribution profile. This distinctive reversed distribution profile is meaningful for exerting a favorable pharmacological effect for finasteride. The drug distribution profile in skin layers showed no significant difference between 12 and 24 hours application (p40.05). The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers.

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Effect of ethosomal minoxidil on dermal delivery and hair cycle of C57BL/6 mice

Cited by 26 publications

References 8 publications

Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect

Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect

Enhanced Transdermal Delivery of Diclofenac Sodium via Conventional Liposomes, Ethosomes, and Transfersomes

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

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