Effect of end-groups on sulfobetaine homopolymers with the tunable upper critical solution temperature (UCST)

Li, Zhi; Hao, Botao; Tang, Yanan; Li, Hao; Lee, Tung‐Chun; Feng, Anchao; Zhang, Liqun; Thang, San H.

doi:10.1016/j.eurpolymj.2020.109704

Cited by 19 publications

(16 citation statements)

References 50 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18,[40][41][42][43][44][45] Furthermore, the presence of even small end group of the polymer can affect their thermoresponsive behavior especially if this group is charged, thus all polymers compared should be prepared with the same polymerization method and if possible have a small, non-ionic group. 18,[46][47][48][49] Thus, in this study a library of 27 PEG based methacrylate polymer was synthesized and characterized to investigate the effect of not only of the number of EGs but also the end group on the EG side group while keeping the end functional groups of the polymers the same. To the best of our knowledge, this is the first time that such an extensive library of PEG based homopolymers has been studied.…”

Section: Introductionmentioning

confidence: 99%

A library of thermoresponsive PEG‐based methacrylate homopolymers: How do the molar mass and number of ethylene glycol groups affect the cloud point?

Constantinou

Georgiou

2020

Journal of Polymer Science

View full text Add to dashboard Cite

In this study, a novel library of thermoresponsive homopolymers based on poly (ethylene glycol) (EG) (m)ethyl ether methacrylate monomers is presented. Twenty-seven EG based homopolymers were synthesized and three parameters, the molar mass (MM), the number of the ethylene glycol groups in the monomer, and the chemistry of the functional side group were varied to investigate how these affect their thermoresponsive behavior. The targeted MMs of these polymers are varied from 2560, 5000, 8200 to 12,000 g mol −1. Seven PEG-based monomers were investigated: ethylene glycol methyl ether methacrylate (MEGMA), ethylene glycol ethyl ether methacrylate (EEGMA), di(ethylene glycol) methyl ether methacrylate (DEGMA), tri(ethylene glycol) methyl ether methacrylate (TEGMA), tri(ethylene glycol) ethyl ether methacrylate (TEGEMA), penta(ethylene glycol) methyl ether methacrylate (PEGMA), nona(ethylene glycol) methyl ether methacrylate (NEGMA). Homopolymers of 2-(dimethylamino) ethyl methacrylate (DMAEMA) were also synthesized for comparison. The cloud points of these homopolymers were tested in different solvents and it was observed that it decreases as the number of EG group was decreased or the MM increased. Interestingly, the end functional group (methoxy or ethoxy) of the side group has an effect as well and is even more dominant than the number of EG groups.

show abstract

Section: Introductionmentioning

confidence: 99%

A library of thermoresponsive PEG‐based methacrylate homopolymers: How do the molar mass and number of ethylene glycol groups affect the cloud point?

Constantinou

Georgiou

2020

Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

“…Of course, our model system with phase-transition temperature lower than 25 °C looks to be not optimal for medicinal usage, although some tasks, including skin delivery, allow for system formulation in a very wide temperature range due to a high ability to cooling without the occurrence of undesired side effects [ 29 , 30 ]. Regardless, the temperature of phase transition of PNAGA-based polymers can be tuned in a wide range by copolymerization or by adjusting the molar mass or end-groups [ 31 , 32 , 33 , 34 , 35 ]. For example, using a hydrophobic dodecyl end-group in RAFT polymerization of NAGA and changing the molar mass, the phase transition upon heating could be tuned in the range from 24 to 43 °C [ 32 ], which covers physiologic temperature range.…”

Section: Discussionmentioning

confidence: 99%

Thermocontrolled Reversible Enzyme Complexation-Inactivation-Protection by Poly(N-acryloyl glycinamide)

et al. 2021

View full text Add to dashboard Cite

A prospective technology for reversible enzyme complexation accompanied with its inactivation and protection followed by reactivation after a fast thermocontrolled release has been demonstrated. A thermoresponsive polymer with upper critical solution temperature, poly(N-acryloyl glycinamide) (PNAGA), which is soluble in water at elevated temperatures but phase separates at low temperatures, has been shown to bind lysozyme, chosen as a model enzyme, at a low temperature (10 °C and lower) but not at room temperature (around 25 °C). The cooling of the mixture of PNAGA and lysozyme solutions from room temperature resulted in the capturing of the protein and the formation of stable complexes; heating it back up was accompanied by dissolving the complexes and the release of the bound lysozyme. Captured by the polymer, lysozyme was inactive, but a temperature-mediated release from the complexes was accompanied by its reactivation. Complexation also partially protected lysozyme from proteolytic degradation by proteinase K, which is useful for biotechnological applications. The obtained results are relevant for important medicinal tasks associated with drug delivery such as the delivery and controlled release of enzyme-based drugs.

show abstract

“…As shown on the LCST above, a higher level of insolubility and hydrophobicity can result in gel formation, whereas the LCST below indicates components of a mixture are completely soluble/miscible for all compositions [ 53 ]. Therefore, most TRHs for drug delivery systems are produced at LCST, because the phase-transition temperature of UCST is less than 25 °C, which limits their biomedical applications [ 54 ]. Polymers used to synthesis LCST-based hydrogels are poly(N,N-diethyl acrylamide) (PDEAM), poly (N-isopropylacrylamide) (PNIPAM), poly(methylvinylether) (PMVE), copolymer blocks of poly(ethylene oxide), poly(N-vinylcaprolactam) (PVC), and poly(pentapeptide) of elastin [ 54 ].…”

Section: Temperature-responsive Hydrogels (Trhs)mentioning

confidence: 99%

Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani

Gasik

2022

IJMS

138

View full text Add to dashboard Cite

Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

show abstract

Effect of end-groups on sulfobetaine homopolymers with the tunable upper critical solution temperature (UCST)

Cited by 19 publications

References 50 publications

A library of thermoresponsive PEG‐based methacrylate homopolymers: How do the molar mass and number of ethylene glycol groups affect the cloud point?

A library of thermoresponsive PEG‐based methacrylate homopolymers: How do the molar mass and number of ethylene glycol groups affect the cloud point?

Thermocontrolled Reversible Enzyme Complexation-Inactivation-Protection by Poly(N-acryloyl glycinamide)

Smart Hydrogels for Advanced Drug Delivery Systems

Contact Info

Product

Resources

About