Smart Hydrogels for Advanced Drug Delivery Systems

Bordbar‐Khiabani, Aidin; Gasik, Michael

doi:10.3390/ijms23073665

Cited by 138 publications

(104 citation statements)

References 106 publications

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“…Hydrogels have long been regarded as ideal drug delivery carries, owing to their efficient drug encapsulation, precise drug transport, and predictable drug release ( Bordbar-Khiabani and Gasik, 2022 ). The porous network and adjustable degradation of hydrogels allow drugs release sustainably ( Daly et al, 2020 ; Ali et al, 2022 ).…”

Section: Biomedical Applications Of Magnetic Hydrogels With Ordered S...mentioning

confidence: 99%

“…Therefore, a growing attention is concentrated on imparting functionality to hydrogels. The functional hydrogels (also referred to as smart hydrogels) obtained optimized structure, enhanced performance and environmentally specific controllability, which greatly extends the application in many areas ( Xia et al, 2013 ; Sikdar et al, 2021 ; Bordbar-Khiabani and Gasik, 2022 ; Sun et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Magnetic hydrogels with ordered structure for biomedical applications

Xue

Sun

2022

Front. Chem.

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Magnetic hydrogels composed of hydrogel matrices and magnetic nanomaterials have attracted widespread interests. Thereinto, magnetic hydrogels with ordered structure possessing enhanced functionalities and unique architectures, show tremendous advantages in biomedical fields. The ordered structure brought unique anisotropic properties and excellent physical properties. Furthermore, the anisotropic properties of magnetic ordered hydrogels are more analogous to biological tissues in morphology and mechanical property, showing better biocompatibility and bioinducibility. Thus, we aim to systematically describe the latest advances of magnetic hydrogels with ordered structure. Firstly, this review introduced the synthetic methods of magnetic hydrogels focus on constructing ordered structure. Then, their functionalities and biomedical applications are also summarized. Finally, the current challenges and a compelling perspective outlook of magnetic ordered hydrogel are present.

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Section: Biomedical Applications Of Magnetic Hydrogels With Ordered S...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetic hydrogels with ordered structure for biomedical applications

Xue

Sun

2022

Front. Chem.

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“…Currently, hydrogels are an attractive type of site-specific drug delivery system, and have many applications in medical and biomedical engineering, including wound and cartilage regeneration, bone tissue engineering, soft robotic components, biosensors, and inflammation relief [ 7 , 8 ]. Hydrogels are used for preparation/manufacturing of contact lenses, scaffolds, wound dressing, and hygiene products [ 9 , 10 ]. The unique properties of hydrogels, such as high water content, flexibility, softness, and biocompatibility, makes them suitable for topical/transdermal delivery.…”

Section: Introductionmentioning

confidence: 99%

“…The pH of the surrounding environment at the pKa and pKb values of the pendant basic and acidic groups influences the swelling of PRHs [ 20 ]. Variations in the pH can occur inside the body due to certain disorders such as inflammation, chronic wounds, and tumors, which are targeted by the drug delivery system [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Chitosan-Gelatin Thermosensitive Hydrogels Containing 5FU-Alginate Nanoparticles for Skin Delivery

Nawaz

Ullah

Alnuwaiser

et al. 2022

Gels

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(1) Background: Chitosan-gelatin-based thermosensitive hydrogel containing 5FU-alginate nanoparticles was formulated for the effective and sustained delivery of 5FU to the skin. (2) Methods: Alginate, a polysaccharide was used for the formulation of nanoparticles using a spray drying technique. Size, zeta potential, and surface morphology were investigated using a zetasizer and scanning electron microscope. The hydrogel was fabricated using chitosan and gelatin. Several important analyses were used to characterize these prepared topical hydrogels. The pH, visual transparency, rheological behavior, and swelling index of the prepared hydrogels were evaluated. The in vitro release studies were performed at different pH (5.5 and 7.4) and temperature (32 and 37 °C) conditions using a Franz diffusion cell. Ex vivo permeation and in vivo studies were performed using Sprague Dawley rats. (3) Results: Results show that spherical nanoparticles were produced at sizes of 202–254 nm and with zeta potentials of −43 to −38 mV. The prepared nanoparticles were successfully incorporated into chitosan-gelatin-based hydrogels using a glycerol 2-phosphate disodium salt hydrates crosslinker. Drug polymers and excipients compatibility and formulation of hydrogels was confirmed by ATR-FTIR results. The pH of the prepared hydrogels was in accordance with the skin pH. The viscosity of prepared hydrogel increased with temperature increase and phase transition (sol-gel transition) occurred at 34 °C. The release of drug was sustained in case of nanoparticles incorporated hydrogels (5FU-Alg-Np-HG) as compared to nanoparticles (5FU-Alg-Np) and simple hydrogels (5FU-HG) (ANOVA; p < 0.05). The premature and initial burst release of 5FU was prevented using 5FU-Alg-Np-HG. The release mechanism of 5FU from the 5FU-Alg-Np-HG diffusion was followed by swelling and erosion, as suggested by Korsmeyer-Peppas model. The prepared hydrogel proved to be non-irritant. Ex vivo permeation study across rat’s skin suggests that permeability of nanoparticles (5FU-Alg-Np) was higher than the 5FU-Alg-Np-HG (ANOVA; p < 0.05). However, skin-related drug retention of 5FU-Alg-Np-HG was significantly higher than the 5FU solution, 5FU-Alg-Np, and 5FU-HG (ANOVA; p < 0.05). This was due to swelling of hydrogels in the lower layers of skin where the temperature is 37 °C. The higher concentration of 5FU in the skin is helpful for treatment of local skin cancer, such as melanoma, and actinic keratosis. In vivo results also confirmed maximum AUC, t1/2, and skin-related drug retention of 5FU-Alg-Np-HG. (4) Conclusion: Chitosan-gelatin-based hydrogels containing 5FU-Alg-Np possess exceptional properties, and can be used for the sustained delivery of 5FU for the treatment of local skin cancers.

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“…These examples indicate the importance of finding an efficient method for improving CCM solubility and its therapeutic performance. To date, many nanoparticles have emerged as promising drug delivery vehicles to enhance the therapeutic efficacy and bioavailability of drugs, such as polymeric micelles, 12 liposomes, 13 dendrimers, 14 hydrogels, 15 and coordination polymers (CPs). 16,17 CPs are infinite systems of metallic ions and organic ligands.…”

Section: Introductionmentioning

confidence: 99%