Effect of Emodin on Expression of VEGF-A and VEGFR_2 Genes in Human Breast Carcinoma MCF-7 Cell

Abstract

Background: Tumor angiogenesis is an important procedure for the tumor development as it confirms oxygen and nutrients source to increase cells through the expansion of new blood vessels, potentially causing cancer development and metastasis. Emodin, a tyrosine kinase inhibitor, is an innate anthraquinone derivative found in the roots and rhizomes of several plants. Pharmacological studies have revealed that emodin displays various biological roles, such as anti-inflammatory, antibacterial and anticancer action. Studies have confirmed that emodin prevents cell growth in some types of cancer cells. Therefore, inhibition of angiogenesis is a new strategy for cancer treatment.

Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

“…Asperlactone has also been reported as a potent antibacterial and antifungal metabolite (Chen et al 2014). Emodin is the most studied anthraquinone derivative for its diverse biological activities, including antibacterial (Hatano et al 1999), antifungal (Kim et al 2004), antioxidant (Izhaki 2002), and anticancer properties (Cheshmi et al 2017;Zhao et al 2017). STC is a polyketide mycotoxin and a precursor of Aflatoxin B1 (AFB1), however, its toxicity is lower than that of AFB1 (Piontek et al 2016).…”