Emodin - A natural anthraquinone derivative with diverse pharmacological activities

Semwal, Ruchi Badoni; Semwal, Deepak Kumar; Combrinck, Sandra; Viljoen, Alvaro

doi:10.1016/j.phytochem.2021.112854

Cited by 79 publications

(35 citation statements)

References 265 publications

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“…Consistently, Yao et al reported that berberine could markedly downregulate P 2 X 7 R expression in MDA-MB-231 cells, leading to reduced cell proliferation and migration [ 32 ]. Similarly, emodin, a compound isolated from rhubarb, buckthorn and Japanese knotweed, with validated anti-cancer activities [ 82 ], could also block P 2 X 7 R. A study by Jelassi B et al demonstrated emodin as a potent P 2 X 7 R antagonist to reduce the invasiveness of human breast and lung cancer cells both in vitro and in vivo. Interestingly, compared to other P 2 XR family members, emodin selectively inhibited P 2 X 7 R-mediated signaling pathways.…”

Section: Natural Small Molecule Compound Targeting Receptor and Its A...mentioning

confidence: 99%

Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

Wang

Zhao

et al. 2022

IJMS

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Receptors are macromolecules that transmit information regulating cell proliferation, differentiation, migration and apoptosis, play key roles in oncogenic processes and correlate with the prognoses of cancer patients. Thus, targeting receptors to constrain cancer development and progression has gained widespread interest. Small molecule compounds of natural origin have been widely used as drugs or adjuvant chemotherapeutic agents in cancer therapies due to their activities of selectively killing cancer cells, alleviating drug resistance and mitigating side effects. Meanwhile, many natural compounds, including those targeting receptors, are still under laboratory investigation for their anti-cancer activities and mechanisms. In this review, we classify the receptors by their structures and functions, illustrate the natural compounds targeting these receptors and discuss the mechanisms of their anti-cancer activities. We aim to provide primary knowledge of mechanistic regulation and clinical applications of cancer therapies through targeting deregulated receptors.

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Section: Natural Small Molecule Compound Targeting Receptor and Its A...mentioning

confidence: 99%

Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

Wang

Zhao

et al. 2022

IJMS

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“… Dong et al, 2016 ). Emodin is an insoluble compound with a melting point of 255°C and is soluble in alcohol and dimethyl sulfoxide ( Semwal et al, 2021 ). Emodin directly regulates both intrinsic and extrinsic apoptosis as well as affects upstream pathways such as the MAPK, PI3K/AKT, VEGFR, and miRNA.…”

Section: Active Ingredients Of Rhei Radix Et Rhizoma Used For Hcc Tre...mentioning

confidence: 99%

Induction of Apoptosis by Metabolites of Rhei Radix et Rhizoma (Da Huang): A Review of the Potential Mechanism in Hepatocellular Carcinoma

et al. 2022

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Liver cancer is a global disease with a high mortality rate and limited treatment options. Alternations in apoptosis of tumor cells and immune cells have become an important method for detailing the underlying mechanisms of hepatocellular carcinoma (HCC). Bcl-2 family, Caspase family, Fas and other apoptosis-related proteins have also become antagonistic targets of HCC. Da Huang (Rhei Radix et Rhizoma, RR), a traditional Chinese herb, has recently demonstrated antitumor behaviors. Multiple active metabolites of RR, including emodin, rhein, physcion, aloe-emodin, gallic acid, and resveratrol, can successfully induce apoptosis and inhibit HCC. However, the underlying mechanisms of these metabolites inhibiting the occurrence and development of HCC by inducing apoptosis is complicated owing to the multi-target and multi-pathway characteristics of traditional Chinese herbs. Accordingly, this article reviews the pathways of apoptosis, the relationship between HCC and apoptosis, the role and mechanism of apoptosis induced by mitochondrial endoplasmic reticulum pathway and death receptor pathway in HCC and the mechanism of six RR metabolites inhibiting HCC by inducing apoptosis.

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“…It is recognized as a protein tyrosine kinase inhibitor and attacks against various tumour cells, including breast, liver, lung and ovarian cancer cells (Tuli et al, 2021). Additionally, EMO is capable of inducing fibroblast apoptosis and improving the lipid accumulation for its anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, antimicrobial and antifibrotic activities (Semwal et al, 2021). Chen et al found that EMO significantly ameliorates albuminuria, inhibits desmin expression, preserves nephrin expression in STZ-induced rats, as well as improving HG-induced EMT and subsequent podocyte dysfunction (Chen et al, 2015).…”

Section: Emodinmentioning

confidence: 99%

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

Yao

Han

et al. 2022

Front. Pharmacol.

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Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes the challenge to patients and their families in general. At present, the therapeutic methods of podocyte injury mainly include angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, steroid and immunosuppressive medications. Nevertheless, the higher cost and side effects seriously disturb patients with podocyte injury. Promisingly, traditional Chinese medicine (TCM) has received an increasing amount of attention from different countries in the treatment of podocyte injury by invigorating spleen and kidney, clearing heat and eliminating dampness, as well enriching qi and activating blood. Therefore, we searched articles published in peer-reviewed English-language journals through Google Scholar, PubMed, Web of Science, and Science Direct. The protective effects of active ingredients, herbs, compound prescriptions, acupuncture and moxibustion for treatment of podocyte injury were further summarized and analyzed. Meanwhile, we discussed feasible directions for future development, and analyzed existing deficiencies and shortcomings of TCM in the treatment of podocyte injury. In conclusion, this paper shows that TCM treatments can serve as promising auxiliary therapeutic methods for the treatment of podocyte injury.

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Emodin - A natural anthraquinone derivative with diverse pharmacological activities

Cited by 79 publications

References 265 publications

Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression

Induction of Apoptosis by Metabolites of Rhei Radix et Rhizoma (Da Huang): A Review of the Potential Mechanism in Hepatocellular Carcinoma

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

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