Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion

Iino, Taeko; Tashima, Kimihito; Umeda, Masakazu; Ogawa, Yoshihiro; Takeeda, Masanori; Takata, Kanji; Takeuchi, Koji

doi:10.1016/s0024-3205(01)01493-x

Cited by 58 publications

(57 citation statements)

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“…Our results are in agreement with previous reports from Ogawa et al [15] and Singh et al [16] with microspheres of ellagic and an ellagic acid rich fraction of Punica granatum extract in dextran sulphate sodium-induced colitis. In a similar way, there has also been described the protective effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion [26].…”

Section: Page 15 Of 37mentioning

confidence: 75%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

149

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t

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Section: Page 15 Of 37mentioning

confidence: 75%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

149

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“…Ellagic acid is a plant-derived polyphenol which has been detected in a wide variety of fruits and nuts, including raspberries, strawberries, walnuts, grapes and black currants (Priyadarsini et al, 2002). Ellagic acid is of particular interest from a dietary viewpoint as it has been reported to have antioxidant (Priyadarsini et al, 2002), antiinflammatory (Iino et al, 2002), antifibrosis (Thresiamma and Kuttan, 1996) and anticancer properties (Narayanan et al, 1999;Skupien et al, 2006). Besides, NIF 1 and 23-HTA isolated from the methanol extracts of unripe fruits of Rubus coreanus have been reported to exert antiinflammatory effects in a carrageenan-induced acute inflammatory animal model, in addition to their antinociceptive actions (Choi et al, 2003;Nam et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening

Yang

Lim

et al. 2007

Phytotherapy Research

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The dried unripe fruit of Rubus coreanus, which is well-known in Korea and referred to as 'Bok-bun-ja', has been employed as a traditional medicine for centuries. This crude drug is utilized in Korea for the management of impotence, spermatorrhea, enuresis, asthma and allergic diseases. The principal objective of the present study was to conduct a comparison of the antiinflammatory effects of ethanol extracts of the unripe (URCE), half-ripened (HRCE) and ripe fruits (RCE) of Rubus coreanus. URCE and HRCE were found to reduce the production of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) as well as pro-inflammatory cytokines, in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. However, RCE exerted no inhibitory effects against the production of NO and IL-6. The results of the study show that the degree of fruit ripening of Rubus coreanus affects the production of inflammatory mediators such as NO, PGE 2 and inflammatory cytokines.

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“…Ellagic acid (EA) (4,4',5',5,6,6'-hexahydroxy diphenic acid 2,6,2',6'-dilactone) is a naturally occurring phenolic lactone compound abundant in berries, pomegranate and other plant foods (Talcott and Lee, 2002). It has wide array of biological properties such as antioxidative (Festa et al, 2001), antiinfl ammatory (Iino et al, 2002), anticarcinogenic (Stoner et al, 1999), antiviral, antibacterial (Atta-Ur-Rahman et al, 2001) and antiproliferative properties (Losso et al, 2004) both in vivo and in vitro. The aim of this study was to evaluate the modulatory role of EA by determining ACF the precancerous lesions, lipid peroxidation, enzymic and non-enzymic antioxidants and histopathological alterations in DMH-induced colon carcinogenic rats.…”

Section: Introductionmentioning

confidence: 99%

Chemomodulation of the antioxidative enzymes and peroxidative damage in the colon of 1,2‐dimethyl hydrazine‐induced rats by ellagicacid

Umesalma

Sudhandiran

2010

Phytotherapy Research

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Prevention of cancer remains a primary need and new chemopreventive agents must be developed for this purpose. Toward this goal, a chemopreventive study was conducted to evaluate the potential effect of ellagic acid (EA) against 1,2-dimethylhydrazine (DMH-) induced colon carcinogenesis in experimental rats. Rats were administered with DMH (20mg/kg body weight) subcutaneous injection once a week for 15 weeks and were supplemented with EA (60 mg/kg body weight/day orally). In the present study, the efficacy of EA on the formation of aberrant crypt foci (ACF), levels of lipid peroxidation (LPO) and activities of enzymic and non-enzymic antioxidants in DMH-induced colon-cancer-bearing rats were assessed. After the experimental period, frequency of ACF, levels of LPO were found to be increased, whereas a significant decrease in the activities of enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase) and non-enzymic antioxidants (reduced glutathione, vitamin C and vitamin E) were observed in DMH-induced rats. Supplementation of EA attenuated all these alterations to near normal levels, which indicates the anti-carcinogenic efficacy of EA. This effect was further confirmed by histopathological studies. The results obtained in the present study suggest EA as an effective chemopreventive agent on colon carcinogenesis induced by DMH.

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Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion

Cited by 58 publications

References 0 publications

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening

Chemomodulation of the antioxidative enzymes and peroxidative damage in the colon of 1,2‐dimethyl hydrazine‐induced rats by ellagicacid

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