Effect of Early Membrane Removal on Regeneration of Class II Furcation Defects in Dogs

Macedo, Guilherme O.; Souza, Sérgio Luı́s Scombatti de; Novaes, Arthur B.; Grisi, Márcio F. M.; Taba, Mário; Palioto, Daniela Bazan

doi:10.1902/jop.2006.77.1.46

Cited by 16 publications

(26 citation statements)

References 41 publications

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“…Therefore, the membrane should be retrieved as soon as the healing clot results in a tissue with sufficient maturity to resist the surgical trauma of the re-entry procedure, inhibiting the apical down growth of gingival epithelium along the root surface and regenerating the periodontal tissues. Previous studies demonstrated that early healing tissues formed in less than 4 weeks may show an arrangement indicative of physical attachment to the dentin and are able to resist tensile forces on the root surface-gingival flap interface during this period (11,12).…”

Section: Discussionmentioning

confidence: 99%

“…At this stage, there is no significant bone or cementum formation. Macedo et al (12) evaluated in dogs the effect of early e-PTFE membrane removal (2 weeks after placement) in the periodontal regeneration of class II furcation defects. The results demonstrated that this procedure promoted the formation of new bone, cementum and periodontal ligament similar to the control group (membrane removal at 4 weeks after placement).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the healing tissues formed under this membrane within 2 weeks seem to have physical and structural characteristics that inhibit the down growth of epithelium and regenerate the periodontal tissues. In different experimental trials, several histological aspects of GTR have been highlighted (12,19,20). Unfortunately, the animals used in these studies showed metabolic rates that were at least more than twice those of humans.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study in dogs, the early e-PTFE membrane removal (2 weeks after placement) showed histomorphometric results (formation of new bone, cementum and periodontal ligament) similar to the membrane removal at 4 weeks after placement, leading to the conclusion that the early removal of e-PTFE membranes did not influence the GTR results (12). Then, it should be of interest to test the hypothesis that early removal of ePTFE membranes in humans does not affect clinically the healing process.…”

Section: Introductionmentioning

confidence: 94%

“…Previous studies have demonstrated that early healing tissues formed in less than 4 weeks may show an arrangement indicative of physical attachment to the dentin and are able to resist tensile forces on the root surface-gingival flap interface during this period (11,12). In a recent study in dogs, the early e-PTFE membrane removal (2 weeks after placement) showed histomorphometric results (formation of new bone, cementum and periodontal ligament) similar to the membrane removal at 4 weeks after placement, leading to the conclusion that the early removal of e-PTFE membranes did not influence the GTR results (12).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Early Membrane Removal on the Treatment of Mandibular Class II Furcation Defects - A Controlled Clinical Trial with Re-entry after 12 Months

et al. 2013

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In a previous study in dogs, the early removal of expanded polytetrafluoroethylene (ePTFE) membrane (2 weeks after placement) showed histomorphometric results (of new bone, cementum and periodontal ligament) similar to that obtained with membrane removal at 4 weeks after placement. This study evaluated the influence of early removal of an ePTFE membrane on the treatment of Class II furcation defects. Twelve patients who provided 12 pairs of mandibular furcation defects were recruited for the study. Baseline clinical measurements were recorded: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival margin position (GMP) and relative clinical attachment level (RCAL). Full flaps were elevated and hard tissue measurements were performed during the surgery: relative vertical (RVBL) and horizontal (RHBL) bone level. The ePTFE membranes were adapted and sutured to their correspondent tooth and removed at 2 weeks in the test group (TGr) and at 4 weeks in the control group (CGr). After 1 year all sites were re-entered, and soft and hard tissue measurements were recorded. There were no statistically significant differences between TGr and CGr for any baseline measurement. After 12 months, there were no statistically significant differences between TGr and CGr in the PD (p=0.74), GMP (p=0.76) and RCAL (p=0.44) values. However, the RHBL resolution was significant for both groups (CGr p=0.01 and TGr p=0.02), without difference between groups (p=0.39). Early removal of membranes did not affect the outcome on the treatment of Class II furcation defects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Early Membrane Removal on the Treatment of Mandibular Class II Furcation Defects - A Controlled Clinical Trial with Re-entry after 12 Months

et al. 2013

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Regenerative Therapy of Furcation Involvements in Preclinical Models

Donos

Palaska

Calciolari

et al. 2018

Diagnosis and Treatment of Furcation‐Involved Teeth

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Comparison of platelet pellet with or without guided tissue regeneration in the treatment of class II furcation defects in dogs

et al. 2008

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The purpose of this study was to compare histological effectiveness of platelet pellet (PP), which has higher platelet content than platelet-rich plasma, and the combination of PP/guided tissue regeneration (GTR) for class II furcation defects in dogs. The mandibular second, third, and fourth premolars of both sides in four dogs were used. Class II furcation defects (5 mm in height and 2 mm in depth) were surgically created. Five weeks after the first operation, second premolars were treated with scaling and root planing (group 1); right third and fourth premolars received PP (group 2), and left premolars received the combination of PP/GTR (group 3). Percentage of cementum and alveolar bone formation were evaluated by histometric analysis after a healing period of 12 weeks. There was new cementum along with periodontal ligament and coronal growth of alveolar bone in all groups. Cementum formation was significantly higher in groups 2 and 3 compared to the control group (P < 0.05) with no significant difference between groups 2 and 3. Limited alveolar bone formation was statistically similar in all groups (P > 0.05). It is concluded that both PP and the combination of PP/GTR are effective in the treatment of class II furcation defects in dogs. PP thus appears to be a suitable alternative material in the regenerative periodontal therapy.

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Effect of Early Membrane Removal on Regeneration of Class II Furcation Defects in Dogs

Abstract: The early removal of ePTFE membranes in Class II furcation defects in dogs did not affect periodontal regeneration.

Cited by 16 publications

References 41 publications

Effect of Early Membrane Removal on the Treatment of Mandibular Class II Furcation Defects - A Controlled Clinical Trial with Re-entry after 12 Months

Effect of Early Membrane Removal on the Treatment of Mandibular Class II Furcation Defects - A Controlled Clinical Trial with Re-entry after 12 Months

Regenerative Therapy of Furcation Involvements in Preclinical Models

Comparison of platelet pellet with or without guided tissue regeneration in the treatment of class II furcation defects in dogs

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