“…Table 1 lists studies of class II and class III furcation defects in animal models-mainly dogs but also baboons and minipigs-treated with a variety of periodontal regenerative agents. The treatments include recombinant human transforming growth factor b3, 32 platelet pellet, 33 polylactide-co-glycolide acid/calcium phosphate bilayered biomaterial, 34 human osteogenic protein-1 and human transforming growth factor-b3, 35 cultured PDL cells, 36 collagen hydrogel/sponge scaffold, 37 enamel matrix derivative with a biphasic calcium phosphate, 38 and bioactive glass/platelet rich plasma. 39 All these animal studies with histology reported new bone growth in furcation defects.…”