Regenerative Therapy of Furcation Involvements in Preclinical Models

Donos, Nikolaos; Palaska, Iro; Calciolari, Elena; Shirakata, Yoshinori; Sculean, Anton

doi:10.1002/9781119270638.ch6

Cited by 3 publications

(9 citation statements)

References 109 publications

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“…88 For many years, preclinical research in the field of regenerative therapies has relied on animals for the testing of new materials and methods before using them in the human clinical setting. 89 Histopathologic evaluation is considered necessary to validate the outcomes of regenerative therapy, 89 which results in the sacrifice of study animals. The wide use of dogs as models has contributed to the understanding of regenerative approaches in humans, although direct extrapolation from preclinical trials to human clinical trials has been disappointing.…”

Section: Partial Tooth Resection Root Resection Hemisection and Trise...mentioning

confidence: 99%

“…The wide use of dogs as models has contributed to the understanding of regenerative approaches in humans, although direct extrapolation from preclinical trials to human clinical trials has been disappointing. 89 Regenerative therapy for stage 3 furcation lesions has been performed with greater success in the preclinical dog studies than in human clinical trials, 46,89 even for chronic lesions. While the lesions in the dog models are usually artificially created, veterinarians and their canine patients may benefit from the results of this research.…”

Section: Partial Tooth Resection Root Resection Hemisection and Trise...mentioning

confidence: 99%

“…In preclinical dog models, regeneration has been investigated in stage 2 and 3 furcation lesions with evaluation of defects of standardized sizes to allow comparison between studies and to avoid spontaneous healing. 89 Most of these studies used an acute/chronic defect model in which the defects are created surgically by removing alveolar bone, periodontal ligament tissue, and cementum at the experimental site, followed by placement of a foreign body before replacing the flap. The site is then left untreated for 1 to 3 months to produce a chronically inflamed lesion similar to that seen in naturally occurring periodontal disease.…”

Section: Partial Tooth Resection Root Resection Hemisection and Trise...mentioning

confidence: 99%

“…The site is then left untreated for 1 to 3 months to produce a chronically inflamed lesion similar to that seen in naturally occurring periodontal disease. 89 Materials and methods that achieve not only some regeneration in comparison with a control group but also reach complete closure and resolution of the furcation lesions are considered the most successful. 89 An acute/chronic study in dogs demonstrated complete closure of stage 2 furcation defects in 3 test groups 8 weeks after autogenous cortical bone graft, autogenous cortical bone graft with platelet-rich plasma, and mesenchymal stem cells with platelet-rich plasma.…”

Section: Partial Tooth Resection Root Resection Hemisection and Trise...mentioning

confidence: 99%

“…89 Materials and methods that achieve not only some regeneration in comparison with a control group but also reach complete closure and resolution of the furcation lesions are considered the most successful. 89 An acute/chronic study in dogs demonstrated complete closure of stage 2 furcation defects in 3 test groups 8 weeks after autogenous cortical bone graft, autogenous cortical bone graft with platelet-rich plasma, and mesenchymal stem cells with platelet-rich plasma. 90 All 3 test groups showed greater cementum formation than the control group, with no significant between-group difference.…”

Section: Partial Tooth Resection Root Resection Hemisection and Trise...mentioning

confidence: 99%

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Diagnosis and Management of Furcation Lesions in Dogs – A Review

Zacher

Marretta

2022

J Vet Dent

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The furcation is the anatomic area where the roots divide on a multirooted tooth. Periodontal disease causing alveolar bone loss can lead to furcation lesions of various stages. Once furcation involvement has occurred, the area can be more difficult to clean or treat due to the complex anatomy and morphology of furcations. Teeth with short root trunks, longer tooth roots, and roots with wide furcation entrance areas/degrees of separation and wide root divergence are considered better candidates for long term maintenance. Dog teeth possess many of these advantageous anatomic features compared to human teeth. Treatment options for teeth with furcation lesions include: closed debridement, open debridement, furcation plasty, tunneling, partial tooth or root resection, root separation (hemisection or trisection), regenerative therapies, or exodontia. There are many factors to consider in determining treatment options. The favorable and unfavorable characteristics for maintenance of teeth with furcation lesions are summarized. Home care and ongoing professional care are important aspects of periodontal disease control for any patient. Studies of systemic and local antibiotic therapies in human patients have not demonstrated reduction of furcation stages, and probiotic effects at furcation sites have not been specifically examined. Human review studies show that most molar teeth once deemed “hopeless” due to stage 3 furcation lesions can be maintained for at least 5 to 15 years with supportive periodontal therapy. Similar long term studies in dogs are needed to improve the evidence-based management of canine patients with furcation lesions.

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Section: Partial Tooth Resection Root Resection Hemisection and Trise...mentioning

confidence: 99%