Effect of Duration of Disease on Ventilatory Function in an Ethnic Saudi Group of Diabetic Patients

Meo, Sultan Ayoub; Drees, Abdul Majeed Al; Ahmed, Jehangeer; Shah, Sayed Fayaz Ahmed; Al-Regaiey, Khalid; Husain, Afzal; Al-Rubean, Khalid

doi:10.1177/193229680700100515

Cited by 12 publications

(15 citation statements)

References 19 publications

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“…In this study, the mean percentage of predicted value of FVC and FEV 1 were significantly lower 4,8,10 . Whereas, FEV 1 /FVC % were non significantly lower in type 1 diabetic male than those of non-diabetic subjects.…”

Section: Discussionmentioning

confidence: 75%

“…Although it can occur at any age but usually found in young people specially who are thin 2 . However, it is a serious, progressive multifactorial disease associated with a number of chronic complications, which include iabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to absolute or relative cardiovascular diseases, nephropathy, neuropathy, retinopathy and lung damage 4 .…”

Section: Introductionmentioning

confidence: 99%

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FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c

Arif

Jahan

Sultana³

et al. 2012

J Bangladesh Soc Physiol

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Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to micro and macrovascular diseases which affect eyes, kidneys, heart, blood vessels, nerves and also lungs. There may be a relationship between type-1 diabetes and reduced lung function. Objectives: To observe FVC, FEV 1 , FEV 1 /FVC % and their relationship with HbA 1 C in type-1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from January to December 2009. A total number of 60 male subjects, from 18-30 years of age was taken and was divided into control and study groups. Among them study group was consisted of 30 type-1 diabetic male patients. Control group was consisted of 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic subjects. All the subjects belonged to lower socio-economic status. For assessment of lung function, FVC, FEV 1 , FEV 1 /FVC % of all the subjects were measured. All of theses tests were done by spirometric method by using a digital Spirometer. Again, to observe glycemic control of blood, glycosylated hemoglobin (HbA 1 c) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by Independent-Samples 't' test and Pearson's correlation coefficient test as applicable. Results: FVC (p <0.001), FEV 1 (p < 0.001), and FEV 1 /FVC% (p < 0.05) were significantly lower in type-1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again FVC and FEV 1 had significant (p < 0.001) negative correlation but FEV 1 /FVC% had non-significant positive correlation with HbA 1 c. Conclusion: Impairment of some lung functions may be found in type-1 diabetic male which may be due to poor glycemic control.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c

Arif

Jahan

Sultana³

et al. 2012

J Bangladesh Soc Physiol

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“…Meo SA et al demonstrated in their study that the duration of diabetes in both type 1 and type 2 diabetes mellitus had no significant effects on the lung function tests when the duration of diabetes mellitus is less than 10 years. On the other hand, when the duration of diabetes was more than 10 years or particularly more than 12 years they found statistically significant effects on the various lung function tests (15) .…”

Section: Discussionmentioning

confidence: 86%

Diabetes mellitus and lung function tests

AL-Ameen¹,

Al-Habbo²

2012

Ann Coll Med Mosul

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Objective:To measure the effects of type 1 and type 2 diabetes mellitus on the various spirometric pulmonary function tests Methods: This study involved 70 diabetic patients, 25 type 1 and 45 type 2 diabetes mellitus, and 45 control group. Type 1 diabetic patients included 14 males and 11 females, their ages ranging from 17-63 years with their mean was 47.12, with SD12.83. Type 2 diabetic patients included 26 males and 19 females; their ages ranging from 19-63 years with their mean 46.67, with SD 9.50. The control group involved 24 males and 21 females, their ages ranging from 13-68 years with their mean 38.78, with SD13.3. The study was conducted in Ibn Sena Teaching Results: There were statistically significant differences between the control group and type 1 diabetes mellitus during the measurements of FVC%, FEV1/FVC% and MMFR%, with statistically significant reductions in their values when compared to controls. Furthermore, type 2 diabetes mellitus has significant effects on FVC%, FEV1 and FEV1/FVC% when compared with the controls, with statistically significant differences from the control group. There were no much differences between them apart from the FVC% which favors type 1 diabetes mellitus over type 2 diabetes mellitus with highly significant P-value. Conclusion: The present study clearly indicates that both type 1 and type 2 diabetes mellitus adversely affects the various pulmonary function tests, and the results are in accord with other previous studies.

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“…Chronic hyperglycemia may cause thickening of alveolar epithelium and pulmonary capillary basal laminae 18 , formation of fibrous tissue in lungs and chest wall 19 , autonomic as well as somatic neuropathy 18 , decreased production of NO 5 . These changes in lung tissue cause reduction of elastic recoil tendency of the alveoli and also reduction of lung volume 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Although it can occur at any age but usually found in young people specially who are thin 3 . It is a serious, progressive multifactorial disease associated with a number of chronic complications, which include cardiovascular disease, nephropathy, neuropathy, retinopathy and lung damage 5 .…”

Section: Introductionmentioning

confidence: 99%

PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c

Arif¹,

Jahan²,

Sultana³

2013

J Bangladesh Soc Physiol

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Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to microvascular, macrovascular and neuropathic diseases which affect eyes, kidneys, heart, blood vessels and also lungs. So, there may be a relationship between type-1 diabetes and reduced lung function. Objectives: To observe PEFR, FEF and MVV and their relationship with HbA 1c in type-1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1 st January and 31 st December 2009. A total 30 type-1 diabetic male subjects, age 18-30 years were taken as study group. Another 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic persons were also included as control. For assessment of lung function PEFR, FEF and MVV of all the subjects were measured by a digital spirometer. Again, to observe glycemic control serum blood glucose and glycosylated hemoglobin (HbA 1c ) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by unpaired't' test and Pearson's correlation coefficient test. Results: PEFR (p<0.001), FEF 25-75 (p<0.001), and MVV (p <0.001) were significantly lower in type-1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again, their PEFR (p < 0.05), FEF (p>0.05), and MVV (p<0.05) were negatively correlated with HbA 1c . Conclusion: The lung functions were lower in type-1 diabetic male in comparison to those of non-diabetic counterpart and this reduction is mainly due to poor glycemic control.

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Effect of Duration of Disease on Ventilatory Function in an Ethnic Saudi Group of Diabetic Patients

Abstract: Abbreviations:

Cited by 12 publications

References 19 publications

FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c

FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c

Diabetes mellitus and lung function tests

PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c

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