PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c

Abstract

Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to microvascular, macrovascular and neuropathic diseases which affect eyes, kidneys, heart, blood vessels and also lungs. So, there may be a relationship between type-1 diabetes and reduced lung function. Objectives: To observe PEFR, FEF and MVV and their relationship with HbA 1c in type-1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1 st January and 31 st December 2009. A total 30 type-1 diabetic male subjects, age 18-30 years were taken as study group. Another 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic persons were also included as control. For assessment of lung function PEFR, FEF and MVV of all the subjects were measured by a digital spirometer. Again, to observe glycemic control serum blood glucose and glycosylated hemoglobin (HbA 1c ) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by unpaired't' test and Pearson's correlation coefficient test. Results: PEFR (p<0.001), FEF 25-75 (p<0.001), and MVV (p <0.001) were significantly lower in type-1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again, their PEFR (p < 0.05), FEF (p>0.05), and MVV (p<0.05) were negatively correlated with HbA 1c . Conclusion: The lung functions were lower in type-1 diabetic male in comparison to those of non-diabetic counterpart and this reduction is mainly due to poor glycemic control.