Effect of duodenal alkalinization on gastric motility

Brown, John C.; Johnson, Lenworth N.; Magee, D. F.

doi:10.1016/s0016-5085(66)80072-0

Cited by 83 publications

(18 citation statements)

References 4 publications

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“…The discovery of this polypeptide had been preceded by the observation that duodenal alkalinization stimulated motility-supposedly by duodenal release of a humoral factor-in denervated canine fundic pouches (Brown et al, 1966). Further studies revealed similar gastric motor activity stimulating properties in pancreozymin (Brown, 1967;Brown and Parkes, 1967) and crude secretin (Brown et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

Effects of 13-nle-motilin on the electrical and mechanical activity of the isolated perfused canine stomach and duodenum.

Green¹,

Ruppin²,

Dl³

et al. 1976

Gut

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SUMMARY Synthetic 13-norleucine-motilin (13-nle-motilin), structural and biological analogue of the naturally-occurring duodenal polypeptide, motilin, is known to stimulate antral and duodenal motor activity in vitro, but delays gastric emptying in man. In this study the direct actions of the synthetic polypeptide on myoelectrical activity and intraluminal pressure have been'studied in the isolated vascular-perfused canine stomach and duodenum. 13-nle-motilin increased intraluminal pressure in the pylorus and duodenum, and dose-response analysis showed the duodenum to be twice as sensitive as the pylorus to the polypeptide. Pressure changes in the antrum were small and not dose-related, but, whereas the basic electrical rhythm in the duodenum was not altered, slow wave frequency, rhythm, and propagation in the antrum were disturbed. Electronic analysis of the duodenal spike increase which accompanied pressure rises demonstrated correlations between increases in spikes, intraluminal pressure, and dose. These results show that the direct effect of the polypeptide on adjacent organs may explain the combination of increased motor activity with delayed gastric emptying as a consequence of disturbance in the co-ordination between antrum, pylorus, and duodenum.

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Section: Discussionmentioning

confidence: 99%

Effects of 13-nle-motilin on the electrical and mechanical activity of the isolated perfused canine stomach and duodenum.

Green¹,

Ruppin²,

Dl³

et al. 1976

Gut

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“…It is possible that motilin is the polypeptide released when the duodenum becomes alkalinized (Brown et al 1966). However, support for this hypothesis must await more intensive comparative studies and the identification of motilin in blood and tissues.…”

Section: Gastric Elgects Of Motikin (M 2 and M 3)mentioning

confidence: 99%

The Further Purification of Motilin, a Gastric Motor Activity Stimulating Polypeptide from the Mucosa of the Small Intestine of Hogs

Brown¹,

Mutt²,

Dryburgh³

1971

Can. J. Physiol. Pharmacol.

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226

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BROWN, J. C., MUTT, V., and DRYBURGH, J. R. 1971. The further purification of motilin, a gastric motor activity stitnulating polypeptide from the mucosa of the small intestine of hogs. Can. J. Physiol. Pharmacol. 49,[399][400][401][402][403][404][405] A polypeptide has been isolated from the duodenal mucosa of hogs and has been named motilin. Motilin stimulates motor activity in both antral and fundic gland area pouches of the stomach of dogs. Pt will stimulate pepsin output, with no change in H' secretion, from fundic gland area pouches. Motilin differs from the other characterized gastrointestinal polypeptides both chemically and in its physiological actions. In particular, the presence of phenylalanine as N-terminal residue, the absence of histidine, and presence of large amounts of glutamic acid and glutamine distinguish it from cholecystokinin-pancreozymin and secretin. BROWN, b. C., MUTT, V.. et DRYRURGII. J . W. 1971. The further purification of motilin, a gastric motor activity stinmulating polypeptide from the nmucosra of the small intestine of hogs. Can. J. Physiol. Pharnmacol. 49, 399-4135.Wous avons is016 B partir de la muqueuse duodenale de porc. un polypeptide que nous avons nomrnk motiline. I1 stimufe la motilitC des poches de I'antre pylorique et du fundus de l'estornac de chien. I1 stirnule kgalernent la libkration de pepsine sans motifier la skcrbtion d'H+ B partir des aires ~Ccrbtrices du fundus. La motiline diffhre des autres polypeptides gastro-intestinaux dbjB connus par caractCristiques chimiques et ses actions physiologiques. En particulier. les caract2res qui le distinguent de la s@cr@tine et du CCK-PZ sont la prCsence de phbnylalanine csmme rksidu N-terminal, l'ahsence d'histidine et l'abondance de glutamine et d'acide glutanmique.

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“…Hexamethonium and atropine together completely abolished the LES response to motilin. We conclude that motilin increases LES pressure by acting on preganglionic cholinergic neurones to release acetylcholine which excites other cholinergic neurones supplying the circular muscle of the LES.Alkalinisation of the duodenum stimulates motor activity of a denervated canine gastric fundal pouch (Brown et al, 1966). Crude duodenal extracts have the same action and recently Brown et al (1971Brown et al ( , 1973 have succeeded in isolating and identifying the complete amino acid sequence of the peptide responsible for this action.…”

mentioning

confidence: 81%

“…Alkalinisation of the duodenum stimulates motor activity of a denervated canine gastric fundal pouch (Brown et al, 1966). Crude duodenal extracts have the same action and recently Brown et al (1971Brown et al ( , 1973 have succeeded in isolating and identifying the complete amino acid sequence of the peptide responsible for this action.…”

mentioning

confidence: 99%

Effect of motilin on the lower oesophageal sphincter.

Meissner¹,

Bowes²,

Zwick³

et al. 1976

Gut

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SUMMARY The effect of motilin on lower oesophageal sphincter (LES) pressure has been studied in unanaesthetised specially trained dogs using an infusion manometric technique. Motilin produced significant rises in resting pressure and contractions of the LES after doses ranging from 0009 ug/kg to 0 05 jug/kg. Doses greater than 005 tg/kg resulted in repetitive high amplitude contractions. Atropine 30 ,ug/kg completely abolished the effect of the lower doses of motilin. Higher doses of motilin in atropinised dogs still caused a small rise in baseline pressure and contractile activity still appeared. Hexamethonium 2 mg/kg resulted in both a diminished rise in LES pressure and the disappearance of contractions after motilin. Hexamethonium and atropine together completely abolished the LES response to motilin. We conclude that motilin increases LES pressure by acting on preganglionic cholinergic neurones to release acetylcholine which excites other cholinergic neurones supplying the circular muscle of the LES.Alkalinisation of the duodenum stimulates motor activity of a denervated canine gastric fundal pouch (Brown et al., 1966). Crude duodenal extracts have the same action and recently Brown et al. (1971Brown et al. ( , 1973 have succeeded in isolating and identifying the complete amino acid sequence of the peptide responsible for this action. This substance, motilin, in a dose of 2,ug/kg intravenously results in a marked increase in both the frequency and strength of antral and fundal contractions.The lower oesophageal sphincter (LES)5 responds to all known gastrointestinal hormones (Cohen and Lipshutz, 1971;Thomas and Earlam, 1973). Purified natural porcine motilin induces phasic changes in LES pressure in anaesthetised dogs (Jennewein et al., 1975). This study was performed to evaluate the type and mechanism of action of motilin on the lower oesophageal sphincter in the unanaesthetised animal.

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Effect of duodenal alkalinization on gastric motility

Cited by 83 publications

References 4 publications

Effects of 13-nle-motilin on the electrical and mechanical activity of the isolated perfused canine stomach and duodenum.

Effects of 13-nle-motilin on the electrical and mechanical activity of the isolated perfused canine stomach and duodenum.

The Further Purification of Motilin, a Gastric Motor Activity Stimulating Polypeptide from the Mucosa of the Small Intestine of Hogs

Effect of motilin on the lower oesophageal sphincter.

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